Conference Description
The Notch Signaling in Development, Regeneration and Disease GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.
The Notch signaling pathway is a central mediator of short-range, inter-cellular communication in multicellular organisms. Alterations of Notch activity underlie a growing list of developmental syndromes, adult onset diseases, and cancers, expanding the interest in this pathway well beyond the boundaries of basic developmental and cell biology and into the areas of stem cell biology, cancer biology and therapeutics. In addition to the premier talks mentioned above, a number of abstracts will be selected for short oral presentations. The inclusion and integration of a Gordon Research Seminar (GRS) exclusively for postdocs and graduate students prior to the GRC is a particular asset to draw new scientists into the field and encourage trainee participation. Most importantly, the combined GRC/GRS format excels in integrating students, postdocs and investigators wishing to enter a new field, such as the study of this important signaling pathway.
Due to limited accommodations at this venue, guest housing is very limited. To request family/guest housing please reach out to your Conference Operations Associate.
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by March 16, 2024. Please check back for updates.
Keynote Session: Setting Notch in Context
Discussion Leaders
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Pamela Stanley (Albert Einstein College of Medicine, United States)
Speakers
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Ellen Rothenberg (California Institute of Technology, United States)
Structure and Mechanisms of Notch Activation and Modulation
Discussion Leaders
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Stephen Blacklow (Harvard Medical School, United States)
Speakers
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Rhett Kovall (University of Cincinnati, United States)
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Hideyuki Takeuchi (University of Shizuoka School of Pharmaceutical Sciences, Japan)
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Pamela Stanley (Albert Einstein College of Medicine, United States)
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Vincent Luca (Moffitt Cancer Center & Research Institute, United States)
Transcription, Epigenetics and Notch
Discussion Leaders
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Sarah Bray (University of Cambridge, United Kingdom)
Speakers
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Tilman Borggrefe (University of Giessen, Germany, Germany)
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Juan Carlos Zuniga-Pflucker (University of Toronto, Canada)
Notch, Development, and Homeostasis
Discussion Leaders
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Christian Siebel (Genentech, United States)
Speakers
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Hamed Jafar-Nejad (Baylor College of Medicine, United States)
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Nadean Brown (University of California, Davis, United States)
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Raphael Kopan (Cincinnati Children's Hospital Medical Center, United States)
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Susan Cole (The Ohio State University, United States)
Late-Breaking Topics in Notch Biology
Discussion Leaders
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David Sprinzak (Tel Aviv University, Israel)
Speakers
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Wendy Gordon (University of Minnesota, United States)
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Emma Andersson (Karolinska Institutet, Sweden)
Notch and Cardiovascular Disorders
Discussion Leaders
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Warren Pear (University of Pennsylvania, United States)
Speakers
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Luisa Iruela-Arispe (Northwestern University, United States)
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Joseph Arboleda-Velasquez (Schepens Eye Research Institute, Mass Eye and Ear / Harvard Medical School, United States)
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Rong Wang (University of California, San Francisco, United States)
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Jose Luis De La Pompa (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain)
Organoids to Study Notch Signaling in Tissue Development and Diseases
Discussion Leaders
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Ishita Jain (Stanford University, United States)
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Thilinie Bandara (University of Illinois at Chicago, College of Medicine, United States)
Speakers
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Gregory Underhill (University of Illinois at Urbana-Champaign, United States)
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Cecilia Sahlgren (Åbo Akademi University, Finland)
Stem Cell and Niche Interactions
Discussion Leaders
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irwin bernstein (Fred Hutchinson Cancer Center, United States)
Speakers
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Linda Samuelson (University of Michigan, United States)
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Brandon Hadland (Fred Hutchinson Cancer Center, United States)
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Silvia Fre (Institut Curie, France)
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Lluc Mosteiro (Genentech, United States)
Notch, Cancer, and Therapeutics
Discussion Leaders
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Jon Aster (Brigham and Women's Hospital, United States)
Speakers
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Ivan Maillard (University of Pennsylvania, United States)
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Freddy Radtke (École Polytechnique Fédérale de Lausanne, Switzerland)
The GRC Power Hour™
Organizers
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Luisa Iruela-Arispe (Northwestern University, United States)
