SATURDAY |
1:00 pm - 5:00 pm | Arrival and Check-in |
3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:45 pm - 4:30 pm | Keynote Session |
| Discussion Leader: Shinya Yamamoto (Chair, Baylor College of Medicine) |
3:45 pm - 4:15 pm | Raphael Kopan (Cincinnati Children's Hospital Medical Center)
"New Technology Developed to Probe Target Selection by Specific Notch Complexes In Vivo" |
4:15 pm - 4:30 pm | Discussion |
4:30 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 8:30 pm | Notch Signaling in Model Organisms |
| Discussion Leaders: Laurie Holt (University of Oxford, UK) and Sarah Bray (University of Cambridge, UK)
|
7:30 pm - 7:45 pm | Erika Sorensen (University of Wisconsin-Madison)
"Visualization of GLP-1/Notch Signaling in Stem Cells Within an Organism"
|
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Kazuya Hori (Harvard Medical School)
"Regulation of Notch Signal by a Lysosomal Associated Transmembrane Protein"
|
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | John Jacob (Oxford University Hospitals NHS Trust)
"Cryptic Notch Signaling Mediates Teratogenic Effects of Valproate in
a Zebrafish Chemical-Genetics Model of Fetal Valproate Syndrome"
|
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:30 pm | Molecular Mechanisms of Notch Signaling |
|
Discussion Leaders: Beth Harvey (Stony Brook University) and Stephen Blacklow (Harvard Medical School)
|
8:30 pm - 8:45 pm | Rolake Alabi (Weill Medical College of Cornell University)
"Understanding the Contributions of ADAM10 and ADAM17 to Notch1 Signaling"
|
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Catherine Deatherage (Vanderbilt University)
"Comparison of the Structures of Gamma-Secretase Substrates Notch and C99-APP" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Roger Habets (Maastricht University, Netherlands)
"Distinct Mechanisms of Regulated Proteolysis Between Mammalian NOTCH Proteins" |
9:25 pm - 9:30 pm | Discussion |
SUNDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:12 am | Notch Signaling in Development and Stem Cells |
| Discussion Leaders: Bahman Rostama (Maine Medical Center Research Institute) and Christian Siebel (Genentech)
|
9:00 am - 9:15 am | Tobias Hohenauer (RIKEN Brain Science Institute)
"Evi1 (Prdm3) Maintains Neural Stem Cell Self-Renewal Through Chromatin Control
Over Notch Target Activation"
|
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Elise Demitrack (University of Michigan)
"Notch Regulates Gastric Antral Lgr5+ Stem Cells to Control Epithelial Cell Homeostasis"
|
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Kai-Yuan Chen (Cornell University)
"A Gradient Modulated NOTCH Intercellular Feedback Controlling Stem Cell/Niche Pattern Inside Intestinal Crypts"
|
9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Kostandin Pajcini (University of Pennsylvania)
"The Notch1 Transcriptional Activation Domain is Required for Development
and Reveals a Novel Role for Notch1 Signaling in Fetal Hematopoietic Stem Cells"
|
10:15 am - 10:20 am | Discussion |
10:20 am - 11:00 am | Panel Discussion: How Notch Signaling Shapes One's Career |
| Discussion Leader: Mustafa Turkoz (Cincinnati Children's Hospital Medical Center) |
| Panelists:
- Stephen Blacklow (Harvard Medical School, USA)
- Sarah Bray (University of Cambridge)
- Alain Israël (Institut Pasteur)
- Raphael Kopan (Cincinnati Children's Hospital Medical Center)
- Warren Pear (University of Pennsylvania)
- Christian Siebel (Genentech)
|
11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Notch Signaling in Disease |
| Discussion Leaders: Gillian Horne (Paul O'Gorman Leukaemia Research Centre, UK) and Warren Pear (University of Pennsylvania, USA)
|
1:30 pm - 1:45 pm | Sarah Peterson (Maine Medical Center Research Institute)
"Notch Signaling in Vascular Remodeling Following Injury"
|
1:45 pm - 1:50 pm | Discussion |
1:50 pm - 2:05 pm | Surajit Sinha (Memorial Sloan Kettering Cancer Center)
"An In Vivo Gain of Function Genetic Screen for Lung Metastasis Identifies
NUMB as an Enforcer of Tumor Dormancy"
|
2:05 pm - 2:10 pm | Discussion |
2:10 pm - 2:25 pm | Jooho Chung (University of Michigan)
"Delta-Like Ligands Expressed by Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity During Graft-Versus-Host-Disease"
|
2:25 pm - 2:30 pm | Discussion |
2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
3:00 pm | Seminar Concludes |