| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Notch1-Induced T-Cell Acute Lymphoblastic Leukemia/Lymphoma (T-ALL) |
| Discussion Leader: Mustafa Turkoz (Cincinnati Children's Hospital Medical Center, USA) |
| 3:45 pm - 4:15 pm | Jon Aster (Harvard Medical School / Brigham and Women's Hospital, USA)
"Notch Signaling in Cancer: Trials and Tribulations on the Road to Therapy" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Molecular Mechanisms of Notch Signaling |
| Discussion Leaders: Michael Schneider (Stony Brook University, USA), Kumiko Kobayashi (Institute for Virus Research, Kyoto University, Japan) and Stephen Blacklow (Harvard Medical School, USA) |
| 7:30 pm - 7:45 pm | Vincent Luca (Stanford University School of Medicine, USA)
"Structure and Engineering of Notch-Ligand Interactions" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Lena Tveriakhina (Hannover Medical School, Germany)
"Characterization of the Functional Divergence of the Mouse Notch Ligands DLL1 and DLL4" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Preetish Kadur Lakshminarasimha Murthy (Cornell University, USA)
"Fringe Mediated Modification of Notch Ligands in the Intestine" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Hiromi Shimojo (iCeMS, Kyoto University, Japan)
"Oscillatory Control of Delta-Like1 in Cell Interactions Regulates Dynamic Gene Expression and Tissue Morphogenesis" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Vivek Kumar (Albert Einstein College of Medicine, USA)
"Fringe-Regulated Notch Signaling in T and B Cell Development" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Kaden Southard (University of California, San Francisco, USA)
"Regulation of Notch Signaling at the Cell Surface Through Receptor Spatial Organization" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Notch Signaling in Development, Homeostasis, Stem Cell Maintenance and Disease |
| Discussion Leaders: Whitney Edwards (University of Illinois at Urbana Champaign, USA), Katrina Slemmons (Duke University, USA) and Warren Pear (University of Pennsylvania, USA) |
| 9:00 am - 9:15 am | Anna Engler (University of Basel, Switzerland)
"Differential Roles of Notch1 and Notch2 Signaling in Adult Neurogenesis" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Daniel Lafkas (Genentech Inc., USA)
"Therapeutic Antibodies Reveal Notch Control of Transdifferentiation in the Adult Lung" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Gregory Farber (Weill Cornell Medical College, USA)
"Role of the ADAM10/Notch Signaling Pathway in the Development of the Glomerular and Epicardial Vasculature" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Russell Ryan (Massachusetts General Hospital, USA)
"Activation of Oncogene Enhancers by Notch Signaling in Small B Cell Lymphomas" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Natacha Bohin (University of Michigan, USA)
"Notch and mTORC1 Regulate the Intestinal Epithelial Regenerative Response" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Qing Wang (University of Michigan, USA)
"The Direct Notch1 Cofactor Zmiz1 Switches from Repressing to Activating Notch1 Signals upon T-Lineage Commitment" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Career Paths in the Notch Signaling World |
| Discussion Leader: Rolake Alabi (Weill Cornell Medical College, USA) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Career Paths in the Notch Signaling World" |
|
- Carl Blobel (Hospital for Special Surgery, Weill Cornell Medicine, USA)
- Sarah Bray (University of Cambridge, United Kingdom)
- Judith Kimble (University of Wisconsin-Madison / Howard Hughes Medical Institute, USA)
- Ivan Maillard (University of Michigan, USA)
- Christian Siebel (Genentech, Inc., USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
