Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Post-Translational Modifications in the Notch Signaling Pathway
Discussion Leader: Daniel Lafkas (Genentech Inc., USA)
3:45 pm - 4:15 pm
Pamela Stanley (Albert Einstein College of Medicine, USA)
"Roles of Glycosylation in Notch Signaling"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dynamic Control of Cell Fate and Function
Discussion Leaders: Qi Yang (Albany Medical College, USA), Adrian Jacobo (Rockefeller University, USA) and ChangHwan Lee (University of Wisconsin-Madison / Howard Hughes Medical Institute, USA)
7:30 pm - 7:45 pm
Eric Perkey (University of Michigan, USA)
"Specialized Fibroblasts in Secondary Lymphoid Organs Program Effector T Cell Responses Through Notch Signals in Graft-Versus-Host Disease and Other Immunological Contexts"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Joshua Adams (Baylor College of Medicine, USA)
"Sox9 Levels Determine the Severity and Progression of Liver Disease in a Mouse Model of Alagille Syndrome"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Craig Jacobs (University of Calgary, Canada)
"PHRESH Analysis Reveals a Role for Notch Signalling in the Maintenance of Hh Response During Spinal Cord Patterning"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Emilie Abby (Wellcome Trust Sanger Institute, United Kingdom)
"Elucidating the Cellular and Molecular Effects of Notch1 Inactivating Mutations in the Oesophagus"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Oscar Stassen (Eindhoven University of Technology, The Netherlands)
"A Biomimetic Cardiovascular-Tissue-on-a-Chip to Study the Interplay Between Notch Signalling and Hemodynamic Loading"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Roshana Thambyrajah (Fundació IMIM, Spain)
"How Much Notch Is Enough for HSC Generation?"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Structural Mechanics and Signaling
Discussion Leaders: Vincent Luca (Moffitt Cancer Center & Research Institute, USA), David Sloas (Boston University, USA) and Anna Erzberger (The Rockefeller University, USA)
9:00 am - 9:15 am
Julia Falo-Sanjuan (University of Cambridge, United Kingdom)
"Dynamics of Transcription from Notch-Responsive Enhancers"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
ChangHwan Lee (University of Wisconsin-Madison / Howard Hughes Medical Institute, USA)
"Dynamics of Notch-Dependent Transcriptional Activation in Its Natural Context"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Eleni Foteinou (University of Manchester, United Kingdom)
"Classifying Mutant Outcomes Arising from Different EGF Domain Mutations Within the Ligand Binding Region of Notch"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Giulia Monticone (University of Manchester, United Kingdom)
"Cancer-Associated Mutations Affect Notch Endocytic Trafficking"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Adrian Jacobo (Rockefeller University, USA)
"Notch-Mediated Polarity Decisions in the Zebrafish's Lateral Line"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Udi Binshtok (Tel Aviv University, Israel)
"Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: From Surviving to Thriving in Research
Discussion Leader: Rachel LoPilato (University of Georgia, USA)
1:30 pm - 2:30 pm
Panel Discussion
From Surviving to Thriving in Research
Vincent Luca (Moffitt Cancer Center & Research Institute, USA)
David Sprinzak (Tel Aviv University, Israel)
Qi Yang (Albany Medical College, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes