Mechanisms of Notch Signaling in Health and Disease

The Gordon Research Seminar on Notch Signaling in Development, Regeneration and Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting-edge ideas in short talks and poster presentations. Attendees will have many opportunities to interact with leaders in the field who will serve as scientific mentors throughout the seminar weekend, before their participation in the associated Gordon Research Conference.

This 4th Notch GRS meeting will focus on the molecular mechanisms of Notch signaling. Subjects will include canonical signaling processes such as ligand-mediated activation, receptor trafficking, and regulation of receptor and ligand activity by other pathway components. Emerging phenomena, including ligand-independent activation, receptor organization at the membrane, and dynamic control of target gene expression, will also be explored. Insights will be derived from biochemistry, structural biology, and genetic engineering techniques applied to systems ranging from model organisms to single molecules.