Cleavage and Ligation
Tom Cech, discussion leader
Tom Cech, "Smaller, better group I ribosomes"
C. A. Fierke, "Mechanism of RNase p-catalyzed cleavage pf pre-tRNA"
Melissa Moore, "Exon ligation: The spliceosome and group II introns"
A. Mondragon, "Structure and function of type I DNA topoisomerases"
Structure and Dynamics
Don Crothers, discussion leader
E. Westhof, "Modelling of RNA tertiary structures from biochemical and sequence data: Usefulness and limits"
G. Varani,
Steve Schultz,
Transcription
Arnold Berk, discussion leader
A. Berk, "Mechanisms an transcriptional activation in eukaryotes"
J. Conaway, "Factors controlling initiation and elongation by RNA polymerase II"
E. C. Friedberg, "The transcription-nucleotide excision repair connection"
R. A. Young, "New components and concepts in regulation of RNA polymerase II"
Translation
Roy Parker, discussion leader
R. Parker,
H. Noller, "Probing spatial proximities in the ribosome"
R. Lehmann, "Role of 3'UTR in translational control"
Replication and Recombination
Elizabeth Blackburn, discussion leader
E. Blackburn, "Synthesis of telomeric DNA"
N. Craig, "The 7 transposition mechanism and target site selection"
R. Craigie, "Structure of HIV-1 integrase"
Nucleic Acid Selection
Jack Szostak, discussion leader
G. Joyce, "In vitro evolution of nucleic acid-based catalytic function"
M. Yarus, "Selection of RNAs to perform translational reactions"
Repair and Modification
Paul Modrich, discussion leader
R. Wood, "Nucleotide excision repair of DNA in mammalian cells"
I. Mellon, "Transcription-coupled DNA repair"
G.-M. Li, "Mismatch repair, genetic stability, and cancer avoidance"
L. Simpson, "Mechanism of RNA editing in trypanosomes"
Walter Keller, "Site-specific editing of nuclear messenger RNA precursors by adenosine to inosine conversion in
vitro"
Assembly and Transport
Iain Mattaj, discussion leader
I. Mattaj, "A nuclear cap binding complex involved in pre-mRNA splicing and RNA transport"
R. Reed, "Mechanisms of splice site selection"
M. Rosbash, "HIV REV protein function and spliceosome assembly in yeast"
G. Dreyfuss, "RNA binding proteins, nuclear transport, and fragile X mental retardation syndrome"
R. Singer,
Synthesis and Therapeutics
Fritz Eckstein, discussion leader
F. Eckstein, "The hammerhead ribozyme: Structure, function, and application"
P. Dervan, "Design of peptides for sequence specific recognition in the minor groove of DNA"
W. Pieken, "Novel 2'-pyrimidine nucleoside triphosphates as polymerase substrates and in SELEX"
B. Froehler, "C-5 propyne-containing oligonucleotides"
S. Brown, "Biophysical studies of peptide-nucleic acids as gene-targeting agents"
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