| Sunday, June 25th (Evening) |
| Session 1 | REPLICATION
Chair: Nicholas Cozzarelli (UC Berkeley) |
| 7:30 PM | Mike Botchan (UC Berkeley)
Targeting ORC to DNA in Drosophila |
| 8:00 PM | Louise Prakash (University of Texas)
Fidelity of yeast and human DNA polymerase eta |
| 8:30 PM | Dale Wigley (Oxford)
Unraveling the mechanism of PcrA helicase |
| 9:00 PM | Alan Grossman (MIT)
DNA replication and the bacterial cell cycle |
| 9:30 PM | Nicholas Cozzarelli (UC Berkeley)
Mechanisms of DNA unlinking and chromosome partitioning
|
| Monday, June 26th (Morning) |
| Session 2 | DNA REARRANGEMENTS
Chair: Tania Baker (MIT - HHMI) |
| 9:00 AM | Nancy Craig (Johns Hopkins - HHMI)
Tn7 transposition |
| 9:30 AM | Tania Baker (MIT - HHMI)
Protein machines controlling Mu transposition |
| 10:00 AM | Marg Oettinger (Mass. General, Harvard)
Controlling the first steps in V(D)J cleavage |
| 10:30 AM | COFFEE BREAK |
| 11:00 AM | Mike Cox (University of Wisconsin)
Recombinational resuscitation of stalled replication forks: the need
for motor proteins |
| 11:30 AM | Jim Haber (Brandeis)
Mechanisms of double-strand break-induced recombination in yeast |
| Monday, June 26th (Evening) |
| Session 3 | GENOMICS and BIOINFORMATICS
Chair: Marty Rosenberg (Smith-Kline Beecham) |
| 7:30 PM | Sean Eddy (Washington University)
Computational screens for noncoding RNA genes in genomes |
| 8:00 PM | Jim Garrels (Proteome, Inc.)
Using comprehensively curated model organism knowledge systems for predictions of protein function
|
| 8:30 PM | John Weinstein (NCI, NIH)
Gene expression profiling: Omics and informatics |
| 9:00 PM | Marty Rosenberg (Smith-Kline Beecham)
Drug discovery using genomic technology - opportunities and hurdles |
| 9:30 PM | Diane Levitan (Schering Plough)
Functional Genomics in C. elegans |
| Tuesday, June 27th (Morning) |
| Session 4 | TRANSCRIPTION AND MODIFICATION
Chair: Steve Buratowski (Harvard)
|
| 7:30 PM | Alex Goldfarb (PHRI)
Functional architecture of RNA polymerase |
| 8:00 PM | Qiang Zhou (UC Berkeley)
Regulation of transcriptional elongation by HIV Tat protein and its cofactors |
| 8:30 PM | Steve Buratowski (Harvard)
Coupling of transcription and mRNA capping |
| 9:00 PM | Jim Manley (Columbia)
Links between mRNA processing and transcription |
| 9:30 PM | Arnie Berk (UC Los Angeles)
Analysis of the mammalian mediator of transcription complex |
| Tuesday, June 27th (Evening) |
| Session 5 | RNA STRUCTURE AND FUNCTION
Chair: Jennifer Doudna (Yale - HHMI) |
| 9:00 AM | Sara Woodson (Johns Hopkins)
Fast and slow mechanisms of RNA folding |
| 9:30 AM | Jack Szostak (Mass. General - HHMI)
Evolvability of RNA aptamers |
| 10:00 AM | Olke Uhlenbeck (University of Colorado)
RNA structure/mechanism |
| 10:30 AM | COFFEE BREAK |
| 11:00 AM | Jennifer Doudna (Yale- HHMI)
Crystal structure of the functional core of the signal recognition particle |
| 11:30 AM | David Draper (Johns Hopkins)
Protein-RNA interactions in the ribosome |
| Wednesday, June 28th (Morning) |
| Session 6 | RNA PROCESSING/TRANSPORT
Chair: Melissa Moore (Brandeis - HHMI) |
| 9:00 AM | Joan Steitz (Yale - HHMI)
Splicing and mRNA stabilty |
| 9:30 AM | Melissa Moore (Brandeis - HHMI)
Pre-mRNA splicing: Exon ligation and beyond |
| 10:00 AM | David Tollervey (Univ. of Edinburgh)
Why process RNA? |
| 10:30 AM | COFFEE BREAK |
| 11:00 AM | Pam Silver (Harvard)
Export of mRNAs and ribosomes out of the nucleus |
| 11:30 AM | Ronald Plasterk (Hubrecht Laboratory, the Netherlands)
Transposon silencing and RNAi in C. elegans |
| Wednesday, June 28th (Evening) |
| Session 7 | TRANSLATION
Chair: Matt Hentze (EMBL) |
| 7:30 PM | Alan Hinnebusch (NIH)
Molecular interactions among translation initiation factor in recruitment of initiator tRNA and recognition of the start codon |
| 8:00 PM | Tatjana Pestova (SUNY)
Ribosomal subunit joining during eukayrotic translation initiation |
| 8:30 PM | Peter Sarnow (Stanford)
Cap-independent translation in eukaryotic mRNAs |
| 9:00 PM | Nahum Sonenberg (McGill University)
Regulation of translation initiation by phosphorylation |
| 9:30 PM | Matt Hentze (EMBL)
Translational control by specific mRNA binding proteins |
| Thursday, June 29th (Morning) |
| Session 8 | RETROELEMENTS AND TELOMERES
Chair: Alan Lambowitz (U. Texas, Austin) |
| 9:00 AM | Haig Kazazian (U. Pennsylvania)
Mammalian L1 retrotransposons and exon shuffling |
| 9:30 AM | Alan Lambowitz (U. Texas, Austin)
Group II intron mobility via reverse splicing into DNA: Mechanism and practical applications |
| 10:00 AM | Anna-Marie Skalka (Fox Chase)
Molecular mechanism of retroviral DNA integration |
| 10:30 AM | COFFEE BREAK |
| 11:00 AM | Robert Craigie (NIH)
Retroviral DNA integrase structure and function |
| 11:30 AM | Vicki Lundblad (Baylor)
Bringing telomerase to the telomere: regulation of telomere replication |
| Thursday, June 29th (Evening) |
| Session 9 | MACROMOLECULAR ASSEMBLIES
Chair: Joachim Frank (Wadsworth Center - HHMI) |
| 7:30 PM | Holger Stark (Phillips University - Marburg, Germany)
Arrangement of RNA and proteins in the spliceosomal U1 snRNP as revealed by electron cryomicroscopy |
| 8:00 PM | Steve Burley (Rockefeller University - HHMI)
Structural biology of eukaryotic gene expression |
| 8:30 PM | Joachim Frank (Wadsworth Center - HHMI)
Structure of the 70S ribosome and its ligand-binding complexes as explored by cryo-EM |
| 9:00 PM | Tom Steitz (Yale - HHMI)
Towards the high resolution X-ray crystal structure of the 50S ribosomal subunit and its complexes with substrates and inhibitors |
| 9:30 PM | Gabriele Varani (Medical Research Council)
Networks of protein-RNA and protein-protein interactions in the assembly of RNA processing complexes |
