Sunday evening
Session 1: | Design and Catalysis |
John Burke, Session Chair
- John Burke, University of Vermont
“Hairpin ribozyme: structure and mechanism”
- Peter Rupert, Fred Hutchinson Cancer Research Center
“Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysis”
- Philip Bevilacqua, Pennsylvania State University
"Characterizing the divalent cation-independent and -dependent self-cleavage channels of the HDV ribozyme"
- Chuck Wilson, University of California, Santa Cruz
“Engineering RNA biosensors and understanding how they work”
- Bernard Yurke, Bell Laboratories
“DNA Based Molecular Motors”
- Nadrian Seeman, New York University
“DNA nanotechnology”
Monday morning
Session 2: | Metal Ion Interactions |
Victor Bloomfield, Session Chair
- Victor Bloomfield, University of Minnesota
“Polyelectrolyte effect on nucleic acids”
- Loren Williams, Georgia Institute of Technology
“Localization of cations by DNA”
- Victoria DeRose, Texas A & M University
“Metal-RNA interactions in ribozymes probed by spectroscopic methods”
- Françoise Livolant, Université Paris Sud
“Conformation, interactions and supramolecular ordering of nucleosome core particles”
Monday evening
Session 3: | Folding and Dynamics |
Karin Musier-Forsyth, Session Chair
- David Millar, Scripps Research Institute
“FRETting About Nucleic Acids”
- Kevin Weeks, University of North Carolina
“Towards a structure and a function for “unfolded” RNA”
- Karin Musier-Forsyth, University of Minnesota
“Nucleic acid chaperone activity of the HIV nucleocapsid protein”
- Carlos Bustamente, University of California, Berkeley
“Unfolding a single RNA molecule reversibly by force”
Tuesday morning
Session 4: | DNA Replication and Repair |
Ken Marians, Session Chair
- Ann Valentine, Pennsylvania State University
“The Primosome in DNA Replication: Macromolecular Interactions”
- Ken Marians, Memorial Sloan Kettering
“Mechanisms of replication fork restart”
- Myron Goodman, University of Southern California
“A 'Cowcatcher' model for SOS lesion-targeted mutations in E. coli involving DNA polymerase V, a sloppier copier, Rec A, SSB and beta clamp”
- Patrick Sung, University of Texas Health Science Center, San Antonio
“Biochemical mechanism of homologous recombination”
- Wei Yang, National Institutes of Health
“Structure and function of DNA mismatch repair proteins”
Tuesday evening
Session 5: | Computational Approaches |
Eric Westhof, Session Chair
- Eric Westhof, IBMC-CNRS Strasbourg
“Non-Watson-Crick base pairs in RNA architecture and recognition”
- Elena Rivas, Washington University
“Identification of novel small noncoding RNAs in Escherichia coli using a probabilistic comparative method”
- Tamar Schlick, New York University
“Polymerase beta kinetics explored by dynamic simulations”
- Gary Stormo, Washington University
“Computational methods for discovering regulatory sites in DNA and RNA sequences”
Wednesday morning
Session 6: | Nucleic Acid-Protein Interactions |
Juli Feigon, Session Chair
- Cynthia Wolberger, Johns Hopkins University
“Combinatorial regulation by Ets and Paired domain proteins”
- James Maher, Mayo Foundation
“DNA flexibility in transcription activation”
- Juli Feigon, University of California, Los Angeles
“Molecular recognition of pre-ribosomal RNA stem-loops by nucleolin”
- Olke Uhlenbeck, University of Colorado, Boulder
“tRNA conformity”
- Christopher Francklyn, University of Vermont
“Structure, function and evolution of class II aminoacyl tRNA synthetases”
Wednesday evening
Session 7: | RNA Polymerase |
Robert Landick, Session Chair
- Sylvie Doublié, University of Vermont
“Structural examination of a template-independent RNA polymerase”
- Seth Darst, Rockefeller University
“Structural studies of prokaryotic transcription”
- David Bushnell, Stanford Univeristy
“Eukaryotic Gene Transcription”
- Dorothy Erie, University of North Carolina
“Allosteric regulation of transcription elongation by nucleoside triphosphates”
- Robert Landick, University of Wisconsin, Madison
“Mechanism of pausing by RNA polymerase”
Thursday morning
Session 8: | Chromatin and Gene Expression |
Sharon Dent, Session Chair
- Sharon Dent, MD Anderson Cancer Center
“Ssn6/Tup1: harnessing chromatin for repression”
- Tom Owen-Hughes, University of Dundee
“Pathways for nucleosome mobilization”
- Geeta Narlikar, Harvard Medical School
“Chaperone-like interconversion of distinct nucleosomal states by a chromatin remodeling enzyme”
- Karolin Luger, Colorado State University
“Nucleosomes on drugs: crystallographic studies on the conformation of nucleosomal DNA”
- Ronen Marmorstein, Wistar Research Institute
“Structure and mechanism of histone acetyltransferases”
Thursday evening
Session 9: | Ribosomes and Translation |
Wolfgang Wintermeyer, Session Chair
- Wolfgang Wintermeyer, Universität Witten/Herdecke
Overview / Introduction
- Harry Noller, University of California, Santa Cruz
“Structural basis of functional interactions in the ribosome”
- Rachel Green, Johns Hopkins University
“Ribosomal components that act as barriers to tRNA translocation”
- Scott Strobel, Yale University
“Exploring the mechanism of rRNA catalyzed protein synthesis”
- Marina Rodnina, Universität Witten/Herdecke
“Kinetics of elongation reactions on the ribosome”
- Eric Jan, Stanford University
“Insight into the mechanism of translational initiation from the A site of the ribosome”
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