| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MOBILE DNA |
| Discussion Leader: Marlene Belfort (New York State Dept. of Health) |
| 7:30 pm - 8:00 pm | Jef Boeke (Johns Hopkins University School of Medicine)
"Retrotransposition and other perverted forms of recombination" |
| 8:00 pm - 8:30 pm | Phoebe Rice (University of Chicago)
"Orchestration of DNA strand exchange by Flp recombinase" |
| 8:30 pm - 9:00 pm | Reid Johnson (UCLA)
"Mechanism of DNA inversion by Hin" |
| 9:00 pm - 9:30 pm | Marlene Belfort (New York State Dept. of Health)
"Mobile introns: Pathways and Proteins" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo Session |
| 9:00 am - 12:30 pm | DNA METABOLISM |
| Discussion Leader: Paul Modrich (Duke University Medical Center) |
| 9:00 am - 9:30 am | Paul Modrich (Duke University Medical Center)
"Molecular mechanisms in human mismatch repair" |
| 9:30 am - 10:00 am | Titia Sixma (Netherlands Cancer Institute)
"Structural studies of MutS in mismatch repair" |
| 10:00 am - 10:30 am | Aziz Sancar (University of North Carolina School of Medicine)
"DNA Damage Recognition and Repair Mechanisms" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Lorena Beese (Duke University Medical Center)
"Observing DNA mispairs and carinogenic lesions during DNA replication" |
| 11:30 am - 12:00 pm | Nicholas Cozzarelli (University of California, Berkeley)
"Mechanisms of Chromosomal Unlinking and Segregation" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | RIBOZYMES |
| Discussion Leader: Anna Marie Pyle (Columbia University) |
| 7:30 pm - 8:00 pm | David Lilley (University of Dundee)
"The structure and active site of the VS ribozyme" |
| 8:00 pm - 8:30 pm | Daniel Herschlag (Stanford University)
"Dissecting the Active Site of an RNA Catalyst" |
8:30 pm - 9:00 pm | Anna Marie Pyle (Columbia University)
"Tertiary architecture and catalysis by group II introns" |
| 9:00 pm - 9:20 pm | Ali Nahvi (Yale University)
"Genetic Control by a Metabolite-binding mRNA" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RNA PROCESSING AND TRANSPORT |
| Discussion Leader: Karen Wassarman (University of Wisconsin-Madison) |
| 9:00 am - 9:30 am | Joan Steitz (Yale University)
"mRNA export" |
| 9:30 am - 10:00 am | Reinhard Luhrmann (Max Planck Institute for Biophysical Chemistry)
"Assembly and structure of the spliceosome" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:00 am | Thomas Tuschl (Max Planck Institute for Biophysical Chemistry)
"A new world of tiny RNAs - siRNAs and miRNAs" |
| 11:00 am - 11:30 am | Frank Slack (Yale University)
"Control of development by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression" |
| 11:30 am - 12:00 pm | Karen Wassarman (University of Wisconsin-Madison)
"Small RNA Regulators in Bacteria" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MODIFIED DNA |
| Discussion Leader: Eric Kool (Stanford University) |
| 7:30 pm - 8:00 pm | Peter Glazer (Yale University School of Medicine)
"Targeted genome modification via triple helix formation" |
| 8:00 pm - 8:30 pm | Joanne Stubbe (Massachusetts Institute of Technology)
"Model for Double-stranded cleavage by a Single Bleomycin" |
| 8:30 pm - 9:00 pm | Peter Nielsen (The Panum Institute)
"Ten years of peptide nucleic acid (PNA). What is new?" |
| 9:00 pm - 9:30 pm | Eric Kool (Stanford University)
"Studies in Synthetic Biology: Mimicking Biomolecules in DNA Replication" |
| 9:30 p.m. - 10:00 p.m. | Stephan Diekmann (Institut fuer Molekulare Biotechnologie)
"FRET in vitro" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TRANSLATION |
| Discussion Leader: Gloria Culver (Iowa State University) |
| 9:00 am - 9:30 am | Gloria Culver (Iowa State University)
"Conformational Changes, Chaperones and Ribosome Assembly" |
| 9:30 am - 10:00 am | Jamie Williamson (Scripps Research Institute)
"The 30S ribosomal subunit: some assembly required" |
| 10:00 am - 10:30 am | Thomas Steitz (Yale University)
"On the structural basis of gene expression" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Peter Moore (Yale University)
"The structural basis of the peptide bond forming activity of the large ribosomal subunit" |
| 11:30 am - 12:00 pm | Harry Noller (University of California, Santa Cruz)
"Functional interactions inside the ribosome" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | RNA SYNTHESIS AND REGULATION |
| Discussion Leader: Thomas Record (University of Wisconsin-Madison) |
| 7:30 pm - 8:00 pm | Thomas Record (University of Wisconsin-Madison)
"Steps in open complex formation by RNA polymerase at the ?pR Promoter" |
| 8:00 pm - 8:30 pm | Richard Gourse (University of Wisconsin-Madison)
"Regulation of transcription without transcription factors" |
| 8:30 pm - 9:00 pm | David Bushnell (Stanford University)
"Structural Basis of Eukaryotic Transcription" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SINGLE MOLECULE EXPERIMENTS |
| Discussion Leader: Helen Hansma (University of California, Santa Barbara) |
| 9:00 am - 9:30 am | Helen Hansma (University of California, Santa Barbara)
"Experiment and theory in atomic force microscopy of DNA" |
| 9:30 am - 10:00 am | Jeff Gelles (Brandeis University)
"Enzyme translocation on DNA: mechanics and mechanisms" |
| 10:00 am - 10:30 am | Stephen Kowalczykowski (University of California, Davis)
"Single-Molecule Visualization of DNA Transactions" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Steve Chu (Stanford University)
"Single molecule experiments on the hairpin ribozyme, the Tetrahymena ribozyme, and (possibly) the ribosome" |
| 11:30 am - 12:00 pm | Vincent Croquette (LPS-ENS)
"Single-molecule experiments on DNA dynamics" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:00 pm | TELOMERE STRUCTURE AND FUNCTION |
| Carol Greider (Johns Hopkins University School of Medicine)/TD> |
| 7:30 pm - 8:00 pm | Vicki Lundblad (Baylore College of Medicine)
"Recruitment of multiple complexes to chromosome ends" |
| 8:00 pm - 8:30 pm | Elizabeth Blackburn (University of California, San Francisco)
"New functions for telomerase RNA bases" |
| 8:30 pm - 9:00 pm | Carol Greider (Johns Hopkins University School of Medicine)
"Telomerase and the consequences of telomere dysfunction" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
