| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GENOMICS AND BIOINFORMATICS |
| Discussion Leader: Sean Eddy (Washington University, St. Louis) |
| 7:30 pm - 8:00 pm | Sean Eddy (Washington University, St. Louis)
"Computational methods for finding structural RNAs in genome sequences" |
| 8:00 pm - 8:30 pm | Tom Gingeras (Affymetrix)
"Evidence of hidden transcriptome and strategies employed to regulate expression of RNA transcripts" |
| 8:30 pm - 9:00 pm | Chris Burge (Whitehead Institute, MIT)
"Bioinformatics of RNA splicing" |
| 9:00 pm - 9:15 pm | Poster talk #1: Kevin Y. Sanbonmatsu (Los Alamos National Lab.)
"The first million atom simulation in biology: towards a movie of the ribosome" |
| 9:15 pm - 9:30 pm | Poster talk #2: Anastasia Khvorova (Dharmacon, Inc.)
"Strategies for design of highly functional, stabilized siRNAs" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CATALYTIC NUCLEIC ACIDS |
| Discussion Leader: Martha Fedor (The Scripps Research Institute) |
| 9:00 am - 9:35 am | Adrian R. Ferré-D'Amaré (Fred Hutchinson Cancer Research Center)
"The hairpin ribozyme: catalysis by transition state stabilization?" |
| 9:35 am - 10:10 am | Martha Fedor (The Scripps Research Institute)
"Two active site nucleobases with complementary roles in hairpin ribozyme catalysis" |
| 10:10 am - 10:45 am | Group Photo / Coffee Break |
| 10:45 am - 11:20 am | Ronald Breaker (Yale University)
"Ribozyme speed limits" |
| 11:20 am - 11:55 am | Carol Fierke (University of Michigan)
"Synergy between the protein and RNA subunits in RNase P" |
| 11:55 am - 12:30 pm | Alfonso Mondragon (Northwestern University)
"Structural studies of the specificity domain of RNase P" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | RNA REGULATION & PROCESSING |
| Discussion Leader: David Bartel (Whitehead Institute, MIT) |
| 7:30 pm - 7:55 pm | David Bartel (Whitehead Institute, MIT)
"Tiny regulatory RNAs in animals, fungi, and plants" |
| 7:55 pm - 8:20 pm | Phil Zamore (University of Massachusetts Medical School)
"Ancient pathways programmed by small RNAs" |
| 8:20 pm - 8:35 pm | Poster Talk #3: Susan Martinis (University of Houston)
"An isolated tRNA synthetase domain supports group I intron splicing" |
| 8:35 pm - 9:00 pm | Roy Parker (University of Arizona)
"Mechanisms and regulation of eukaryotic mRNA turnover" |
| 9:00 pm - 9:30 pm | Reinhard Luhrmann (Max-Planck-Institute, Göttingen)
"Structural dynamics of the spliceosome" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NUCLEIC ACID MODIFICATIONS & THERAPEUTICS |
| Discussion Leader: Martin Egli (Vanderbilt University) |
| 9:00 am - 9:35 am | Martin Egli (Vanderbilt University)
"Nucleic Acids with Altered Sugars: Adding a New Twist to DNA" |
| 9:35 am - 10:10 am | John Rossi (City of Hope)
"siRNA expression in human cells, mechanisms and functional consequences" |
| 10:10 am - 10:25 am | Poster Talk #4: Nancy Greenbaum (Florida State University)
"Role of a conserved pseudouridine in pre-mRNA branch site conformation" |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Brenda Bass (University of Utah)
"dsRNA binding proteins in RNA editing and RNA interference" |
| 11:20 am - 11:55 am | Steven A. Benner (University of Florida)
"Halting steps towards a synthetic biology" |
| 11:55 am - 12:30 pm | Osamu Nureki (University of Tokyo)
"Structural basis for RNA maturation" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHROMATIN AND TRANSCRIPTION |
| Discussion Leader: Seth Darst (Rockefeller University) |
| 7:30 pm - 7:55 pm | Seth Darst (Rockefeller University)
"Structural studies of prokaryotic transcription" |
| 7:55 pm - 8:10 pm | Poster Talk #5: Jennifer Hines (Ohio University)
"Structure-Function Studies of Bacillus subtilis T-box Antiterminator RNA" |
| 8:10 pm - 8:35 pm | Laszlo Tora (IGBMC, Strasbourg)
"The role of different TAF-containing complexes in regulation of gene expression" |
| 8:35 pm - 9:00 pm | Karolin Luger (Colorado State University)
"Recognition and dynamics of nucleosomal DNA" |
| 9:00 pm - 9:30 pm | Bradley R. Cairns (University of Utah)
"Chromatin remodeling involves DNA translocation on nucleosomes" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TRANSLATION |
| Discussion Leader: Harry Noller (University of California, Santa Cruz) |
| 9:00 am - 9:35 am | Harry Noller (University of California, Santa Cruz)
"Long-distance communication inside the ribosome" |
| 9:35 am - 10:10 am | Venki Ramakrishnan (MRC Laboratory of Molecular Biology)
"Insights into the decoding mechanism from structures of the 30S subunit" |
| 10:10 am - 10:25 am | Poster Talk #6: Richard Roberts (California Institute of Technology)
"Expansion of the Genetic Code Using mRNA Display" |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Albert E. Dahlberg (Brown University)
"Probing functional sites in the ribosome" |
| 11:20 am - 11:55 am | Rachel Green (Johns Hopkins University)
"Functional analysis of the peptidyl transferase center of the ribosome" |
| 11:55 am - 12:30 pm | Olke Uhlenbeck (Northwestern University)
"Why tRNAs are different" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:15 pm - 7:30 pm | Business Session |
| 7:30 pm - 9:30 pm | DNA REPLICATION, RECOMBINATION & REPAIR |
| Discussion Leader: John Tainer (The Scripps Research Institute) |
| 7:30 pm - 8:00 pm | John Tainer (The Scripps Research Institute)
"Envisioning conformational controls in DNA recombination and repair" |
| 8:00 pm - 8:30 pm | John Essigmann (MIT)
"DNA damaging agents programmed to disrupt transcription and repair" |
| 8:30 pm - 9:00 pm | Cynthia T. McMurray (Mayo Clinic)
"Hijacking of mismatch repair to cause the expansion mutation" |
| 9:00 pm - 9:30 pm | Sam Wilson (National Institute of Environmental Health Sciences)
"Mechanism of DNA polymerase specificity and efficiency" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 12:50 pm | FOLDING & RECOGNITION |
| Discussion Leader: Sarah Woodson (Johns Hopkins University) |
| 8:30 am - 9:05 am | Sarah Woodson (Johns Hopkins University)
"Core issues in ribozyme folding"
|
| 9:05 am - 9:20 am | Poster Talk #7: Jim Maher (Mayo Foundation)
"RNA mimicry of DNA in a selected aptamer for transcription factor NF-kappaB" |
| 9:20 am - 10:30 am | Coffee Break |
| 10:30 am - 11:05 am | Renée Schroeder (Institute of Microbiology and Genetics, Vienna)
"In vivo folding of the td group I intron pre-mRNA" |
| 11:05 am - 11:40 am | David Draper (Johns Hopkins University)
"RNA folding: specific roles for diffuse ions" |
| 11:40 am - 12:15 pm | Alan Lambowitz (University of Texas, Austin)
"Mode of action of a DEAD-box protein that functions as an RNA chaperone in group I intron splicing" |
| 12:15 pm - 12:50 pm | Stephen Cusack (EMBL, Grenoble)
"tRNA recognition by aminoacyl-tRNA synthetases" |
| 12:50 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SINGLE MOLECULE STUDIES |
| Discussion Leader: Nils Walter (University of Michigan) |
| 7:30 pm - 7:55 pm | Nils Walter (University of Michigan)
"Single-molecule fluorescence microscopy of the hairpin ribozyme reveals elementary principles of RNA folding" |
| 7:55 pm - 8:20 pm | Ignacio Tinoco, Jr. (University of California, Berkeley)
"Unfolding RNA molecules by force" |
| 8:20 pm - 8:35 pm | Poster Talk #8: Mark Williams (Northeastern University)
"Mechanical Measurement of Single Molecule Binding Rates: Kinetics of DNA Helix-Destabilization by T4 Gene 32 Protein" |
| 8:35 pm - 9:00 pm | Taekjip Ha (University of Illinois, Urbana-Champaign)
"Single molecule dynamics of DNA recombination intermediates" |
| 9:00 pm - 9:30 pm | Jonas Korlach (Cornell University)
"Single molecule DNA polymerase kinetics studied in zero-mode waveguides" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
