| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GENOMIC STABILITY AND MODIFICATION |
| Discussion Leader: Carol Greider (Johns Hopkins University) |
| 7:30 pm - 8:00 pm | Carol Greider (Johns Hopkins University)
"Telomerase and the consequences of telomere dysfunction" |
| 8:00 pm - 8:30 pm | Christopher Pearson (Hospital for Sick Children, Toronto)
"Processing Disease-Associated Slipped-Strand DNAs by Human Cell Extracts" |
| 8:30 pm - 9:00 pm | David Livingston (Harvard)
“Functional Analysis of the BRCA1 Gene Product” |
| 9:00 pm - 9:20 pm | Short promoted talk: Brian Green
"Re-replication leads to DNA damage" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HELICASES AND NUCLEIC ACID REMODELING |
| Discussion Leader: Steve Kowalczykowski (U. California, Davis) |
| 9:00 am - 9:30 am | Virginia Zakian (Princeton University)
"Pif1 family helicases: effects on fork progression and telomerase" |
| 9:30 am - 10:00 am | Steve Kowalczykowski (U. California, Davis)
"Single-Molecule Biochemistry: Visualization of Enzymatic Transactions on Individual DNA Molecules" |
| 10:00 am - 10:40 am | Group Photo / Coffee Break |
| 10:40 am - 11:10 am | James Berger (U. California, Berkeley)
"Structural basis for DNA wrapping and supercoiling by the gyrase C-terminal domain" |
| 11:10 am - 11:40 am | Karin Musier-Forsythe (University of Minnesota)
"Nucleic Acid Chaperone Activity of the HIV Nucleocapsid Protein" |
| 11:40 am - 12:00 pm | Short promoted talk:
Daniel Kaplan
"Twin DNA Pumps of a Hexameric Helicase Provide Power to Simultaneously Melt Two Duplexes"
|
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DNA REPLICATION AND RECOMBINATION |
| Discussion Leader: Patrick Sung (Yale University) |
| 7:30 pm - 8:00 pm | Patrick Sung (Yale University)
"Mechanisms of General Recombinases in Eukaryotes |
| 8:00 pm - 8:30 pm | Steve Bell (MIT)
"ORC, ATP and the assembly of Mcm2-7 at origins" |
| 8:30 pm - 9:00 pm | Tom Ellenberger (Harvard University)
"Visualizing the Endgame of DNA Replication" |
| 9:00 pm - 9:20 pm | Short promoted talk: Gerald Hsu
"Structures of mismatch replication errors observed in a DNA polymerase" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TRANSLATION AND ITS REGULATION |
| Discussion Leader: Jamie Cate (University of California, Berkeley) |
| 9:00 am - 9:30 am | Joachim Frank (State University of New York, Albany)
"Decoding and tRNA accommodation as seen by cryo-EM" |
| 9:30 am - 10:00 am | Jamie Cate (University of California, Berkeley)
"Mechanisms of translation initiation in eukaryotes" |
| 10:00 am - 10:30 am | Harry Noller (U. California, Santa Cruz)
"Studies on Ribosome Function and Dynamics" |
| 10:30 am - 11:10 am | Coffee Break |
| 11:10 am - 11:40 am | Thomas Steitz (Yale University)
"Recent insights into the peptidyl transferase center of the large ribosomal subunit" |
| 11:40 am - 12:10 pm | Elke Deuerling (University of Heidelberg)
"Structural aspects of co-translational protein folding" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | REGULATORY RNAS |
| Discussion Leader: Elizabeth Goodwin (University of Wisconsin) |
| 7:30 pm - 8:00 pm | Elizabeth Goodwin (University of Wisconsin)
"Identification of a new class of non-coding RNAs that control development" |
| 8:00 pm - 8:30 pm | Barbara Panning (University of California San Francisco)
"Xist RNA and regulation of chromatin structure" |
| 8:30 pm - 9:00 pm | Frank Slack (Yale University)
"Multiple, dynamic miRNPs with selective microRNA binding properties in C. elegans" |
| 9:00 pm - 9:20 pm | Short promoted talk: I-hung Shih
"Validation of mammalian microRNA targets" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RNA TERTIARY STRUCTURE AND CATALYSIS |
| Discussion Leader: Eric Westhof (CNRS, Strasbourg) |
| 9:00 am - 9:30 am | Scott Strobel (Yale University)
"Crystal structure of an intact self-splicing intron with both exons" |
| 9:30 am - 10:00 am | Nils Walter (U. Michigan)
"Lumos! or Seeing is believing: Structural dynamics and function are closely linked in RNA enzymes" |
| 10:00 am - 10:20 am | Short promoted talk: Frank Murphy
"tRNA modifications in decoding" |
| 10:20 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Jennifer Doudna (U. California, Berkeley)
"A conformational switch controls hepatitis delta virus ribozyme catalysis" |
| 11:30 am - 12:00 pm | Eric Westhof (CNRS, Strasbourg)
"The ribosomal A-site: a RNA switch targetted by antibiotics" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHROMATIN ORGANIZATION AND CONFORMATION |
| Discussion Leader: Danesh Moazed (Harvard University) |
| 7:30 pm - 8:00 pm | Timothy J. Richmond
"DNA Structure in Chromatin" |
| 8:00 pm - 8:30 pm | Danesh Moazed (Harvard University)
"Small RNAs and heterochromatin assembly" |
| 8:30 pm - 8:50 pm | Short promoted talk: Christiane Schaffitzel
"Telomeric Guanine Quadruplex DNA in Ciliate Nuclei" |
| 8:50 pm - 9:10 pm | Short promoted talk: Doug Daniels
"Mechanisms of DNA binding and damage location by the human DNA repair protein AGT" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RNA PROCESSING, STABILITY AND GENE EXPRESSION |
| Discussion Leader: Lynne Maquat (University of Rochester) |
| 9:00 am - 9:30 am | Robert Darnell (Rockefeller University)
"Regulation of RNA expression in neurons and neurologic disease" |
| 9:30 am - 10:00 am | Melissa Jurica (University of California, Santa Cruz)
"Structural studies of the dynamic human spliceosome" |
| 10:00 am - 10:40 am | Coffee Break |
| 10:40 am - 11:10 am | Lynne Maquat (University of Rochester)
"Nonsense-mediated mRNA decay in mammalian cells: Splicing- dependent degradation that occurs 5'-to-3' and 3'-to-5' as a consequence of a 'pioneer: round of translation'" |
| 11:10 am - 11:40 am | Traci M.T. Hall (NIEHS/NIH)
"Size selective recognition of siRNA by an RNA silencing suppressor" |
| 11:40 am - 12:00 pm | Short promoted talk: Fred LaRiviere
"Down regulation of non-functional rRNAs in Yeast" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DNA DAMAGE AND REPAIR |
| Discussion Leader: Sheila S. David (University of Utah) |
| 7:30 pm - 8:00 pm | Paul Modrich (Duke University)
"Human mismatch repair in a defined system" |
| 8:00 pm - 8:30 pm | Steve Elledge
"Sensing and responding to DNA damage" |
| 8:30 pm - 9:00 pm | Sheila S. David (University of Utah)
"Detection of 8-oxoG:A Mismatches by the Adenine Glycosylase MutY" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
