| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Chromosome Structure and Maintenance |
| Discussion Leader: Thomas Cech (Howard Hughes Medical Institute) |
| 7:30 pm - 8:00 pm | Thomas Cech (Howard Hughes Medical Institute)
"Telomeres: where RNA meets DNA meets proteins" |
| 8:00 pm - 8:30 pm | Kathleen Collins (University of California, Berkeley)
"Beyond the Template: Telomerase RNA Roles in RNP Assembly and Function" |
| 8:30 pm - 9:00 pm | Martin Gorovsky (University of Rochester)
"Studies on an RNAi-like mechanism of germline DNA elimination in Tetrahymena thermophila" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RNAi and MicroRNA |
| Discussion Leader: David Bartel (Massachusetts Institute of Technology) |
| 9:00 am - 9:30 am | David Bartel (Massachusetts Institute of Technology)
"MicroRNAs and their regulatory targets" |
| 9:30 am - 10:30 am | Phillip Zamore (University of Massachusetts)
"RNA silencing: complexity and other recurring themes" |
| 10:00 am | Coffee Break / Group Photo |
| 10:40 am - 11:10 am | Leemor Joshua-Tor (Cold Spring Harbor Laboratory)
"Argonaute: The Secret Life of Slicer" |
| 11:10 am - 11:40 am | Garrett A. Soukup (Creighton University School of Medicine)
Promoted talk - "MicroRNA expression in a developing mammalian neurosensory organ" |
| 11:40 am - 12:00 pm | Thomas Duchaine (University of Massachusetts)
"DCR-1 proteomics identifies new RNAi-silencing factors and provides evidence for competition between small-RNA-mediated pathways in C. elegans" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | RNA-mediated Regulation in Bacteria |
| Discussion Leader: Charles Yanofsky (Stanford University) |
| 7:30 pm - 8:00 pm | Charles Yanofsky (Stanford University)
"Regulation of tryptophan synthesis in Bacillus subtilis and tryptophan degradation in Escherichia coli" |
| 8:00 pm - 8:30 pm | Robert Batey (University of Colorado, Boulder)
"Guanine Riboswitch Crystal Structure: The Basis for Ligand Specificity by a Natural RNA Aptamer" |
| 8:30 pm - 9:00 pm | Karen Wassarman (University of Wisconsin)
"A Highly Conserved Structure is Required for 6S RNA Activity" |
| 9:00 pm - 9:30 pm | Andrew Feig (Indiana University)
"Understanding Hfq-dependent Post-Transcriptional Gene Regulation at the Molecular Level" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DNA Replication and Recombination |
| Discussion Leader: Lorena Beese (Duke University) |
| 9:00 am - 9:30 am | Lorena Beese (Duke University)
"Error-prone replication of damaged DNA by a high-fidelity DNA polymerase" |
| 9:30 am - 10:00 am | Phoebe Rice (University of Chicago)
"Mechanism of Flp-mediated DNA recombination" |
| 10:00 am - 10:30 am | Stephen Benkovic (Pennsylvania State University)
"Studies on the T4 Replisome" |
| 10:30 am | Coffee Break |
| 11:10 am - 11:40 am | Karl-Peter Hopfner (University of Munich)
"Structural mechanism of SWI2/SNF2 ATPases" |
| 11:40 am - 12:10 pm | Sua Myong (University of Illinois Urbana-Champaign)
Promoted talk - "Deterministic shuttling of a DNA motor protein" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Nucleic Acids Structure and Dynamics |
| Discussion Leader: Carlos Bustamante (University of California, Berkeley) |
| 7:30 pm - 8:00 pm | Carlos Bustamante & Yann Chemla (University of California, Berkeley)
"Mechanism of Force Generation of a Viral DNA Packaging Motor" |
| 8:00 pm - 8:30 pm | Rob Phillips (California Institute of Technology)
"DNA in a Tight Squeeze: the Physics of DNA Packing in Viruses and Eukaryotes" |
| 8:30 pm - 9:00 pm | Vincent Croquette (ENS-CNRS, Paris)
"Investigating topoisomerases cycle by cycle with magnetic tweezers" |
| 9:00 pm - 9:30 pm | Anna Marie Pyle (Yale University)
"Stepwise tracking and remodeling of RNA by SF2 helicases" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DNA Damage, At-Risk Motifs and Repair |
| Discussion Leader: Samuel Wilson (NIEHS) |
| 9:00 am - 9:30 am | Samuel Wilson (NIEHS)
"The Chemical Biology of DNA Synthesis" |
| 9:30 am - 10:00 am | Cynthia Burrows (University of Utah)
"Oxidative Damage Beyond 8-OxoG" |
| 10:00 am - 10:30 am | Cynthia McMurray (Mayo Clinic)
"Repair of Oxidative damage causes CAG expansion in Huntington's Disease" |
| 10:30 am | Coffee Break |
| 11:10 am - 11:40 am | Claire Wyman (Erasmus MC, Rotterdam)
Promoted talk - "A DNA binding induced switch in human Rad50/Mre11/Nbs1 conformation favors tethering broken ends" |
| 11:40 am - 12:10 pm | Justin Courcelle (Mississippi State University)
Promoted talk - "Structural intermediates induced when replication encounters DNA damage" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Ribosomes and Translation |
| Discussion Leader: Matthias Hentze (EMBL, Heidelberg) |
| 7:30 pm - 8:00 pm | Matthias Hentze (EMBL, Heidelberg)
"Fail safe mechanisms for the control of protein synthesis" |
| 8:00 pm - 8:30 pm | Joseph Puglisi (Stanford University)
"Dynamics of translation" |
| 8:30 pm - 9:00 pm | James Williamson (The Scripps Research Institute)
"Assembly Landscape of the 30S Ribosomal Subunit" |
| 9:00 pm - 9:30 pm | Nenad Ban (ETH, Zurich)
"Structural insights into co-translational protein folding and targeting" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Transcription and Chromatin |
| Discussion Leader: Joan Conaway (Stowers Institute) |
| 9:00 am - 9:30 am | Joan Conaway (Stowers Institute)
"Transcriptional Regulatory Complexes, a Proteomics Approach" |
| 9:30 am - 10:00 am | Michael Hampsey (Robert Wood Johnson Medical School)
"The CPF 3'-end processing complex mediates RNA polymerase II promoter-terminator interactions in yeast" |
| 10:00 am - 10:30 am | Richard Gourse (University of Wisconsin)
"Regulation of transcription initiation by novel transcription factors that inhabit the secondary channel of RNA polymerase" |
| 10:30 am | Coffee Break |
| 11:10 am - 11:40 am | Jeff Gelles (Brandeis University)
"Interconvertable lac repressor-DNA looped complexes revealed by single-molecule techniques" |
| 11:40 am - 12:10 pm | P.K.R. Kumar (National Institute of Advanced Industrial Science and Technology, Japan)
Promoted talk - "Structural basis of HutP-mediated anti-termination" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | RNA Processing |
| Discussion Leader: Allan Jacobson (University of Massachusetts, Worcester) |
| 7:30 pm - 8:00 pm | Allan Jacobson (University of Massachusetts, Worcester)
"Aberrant termination triggers nonsense-mediated mRNA decay" |
| 8:00 pm - 8:30 pm | Holger Stark (Max Planck Institute)
"Cryo-EM studies of snRNPs and spliceosomal complexes" |
| 8:30 pm - 9:00 pm | Brent Graveley (University of Connecticut)
"Dscam alternative splicing: The making of 38,000 isoforms" |
| 9:00 pm - 9:30 pm | Alexei Kazantsev (University of Colorado)
Promoted talk - "Crystal structure of bacterial RNase P RNA at ~3.3 angstrom resolution" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
