| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE LECTURES ON THE 75TH ANNIVERSARY OF THE GORDON CONFERENCES |
| 7:30 pm - 8:20 pm | Phillip Sharp (Massachusetts Institute of Technology)
"History of Nucleic Acids Research" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:20 pm | Richard Dickerson (University of California Los Angeles)
"DNA and Proteins: Third Raven From the Ark" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RNA INTERFERENCE |
| Discussion Leader: Phillip Sharp (Massachusetts Institute of Technology) |
| 9:00 am - 9:25 am | Phillip Sharp (Massachusetts Institute of Technology)
"Studies of Small RNAs in Mammalian Systems" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Narry Kim (Seoul National University)
"Molecular basis of microRNA processing by RNase III proteins" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break/Group Photo |
| 10:40 am - 11:05 am | Qinghua Liu (University of Texas Southwestern Medical Center)
"Role of Loqs/R3D1 in maintenance of germline stem cells" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:35 am | Pete Beal (University of Utah)
"Chemical approaches to the control of RNA function in RNAi and miRNA pathways" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Carl Correll (Rosalind Franklin University of Medicine and Science)
"Mechanistic insights into RNA chaperone activities essential for ribosome biogenesis" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CHROMATIN AND REGULATION |
| Discussion Leader: Bob Kingston (Harvard Medical School) |
| 7:30 pm - 7:55 pm | Bob Kingston (Harvard Medical School)
"Noncovalent Modification of Chromatin Structure" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Tom Owen-Hughes (University of Dundee)
"Mechanisms for ATP dependent chromatin remodeling" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Michelle Wang (Cornell University)
"Single Molecule Studies of Nucleosome Stability" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Danesh Moazed (Harvard Medical School)
"RNAi and heterochromatin" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TRANSLATION |
| Discussion Leader: Harry Noller (University California at Santa Cruz) |
| 9:00 am - 9:25 am | Harry Noller (University California at Santa Cruz)
"Ribosome structure, function and dynamics" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Jamie Cate (University of California at Berkeley)
"Structures of the E. coli 70S ribosome" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:25 am | Olke Uhlenbeck (Northwestern University)
"Tuning tRNAs for Translation" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:10 am - 11:35 am | Erin Duffy (Rib-X Pharmaceuticals)
"Structure-Based Drug Design Targeting Infectious Disease" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:05 am | Christian Spahn (University of Berlin)
"Structure of the ribosome-bound cricket paralysis virus IRES RNA" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NUCLEIC ACID DYNAMICS |
| Discussion Leader: Anna Pyle (Yale University) |
| 7:30 pm - 7:55 pm | Anna Pyle (Yale University)
"A look under the hood of molecular motors that remodel RNA and RNA-protein complexes" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Taekjip Ha (University of Illinois at Urbana-Champaign)
"Observing single proteins on single stranded DNA: Orchestration of helicase, RecA and SSB" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Paul Rothemund (California Institute of Technology)
"Generation of arbitrary nanoscale shapes and patterns by scaffolded DNA origami" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Marty Fedor (Scripps Research Institute)
"Assembly of RNA structures in vivo: Rapid conformational exchange or delayed folding?" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GENOME STRUCTURE AND MAINTENANCE - Supported by The Ellison Medical Foundation |
| Discussion Leader: Roland Kanaar (Erasmus University Rotterdam) |
| 9:00 am - 9:25 am | Roland Kanaar (Erasmus University Rotterdam)
"Action of genome maintenance machines in DNA recombination" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Arthur Landy (Brown University)
"Accessory DNA-bending proteins confer a complex contour on the 99 bp regulatory DNA of the bacteriophage Lambda att site as determined by triangulation of FRET distances" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Eric C. Greene (Columbia University)
"Visualizing DNA mismatch repair proteins in action" |
| 10:20 am - 10:25 am | Discussion |
| 10:25 am - 11:10 am | Coffee Break |
| 11:10 am - 11:30 am | Manolis Papamichos-Chronakis (U of Massachusetts)
"Regulation of the DNA damage checkpoint response by the INO80 and SWR1 chromatin remodeling complexes" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 11:55 am | Roberto Pezza (National Institutes of Health)
"Dissecting the function of the Hop2-Mnd1 complex during homologous recombination" |
| 11:55 am - 12:00 am | Discussion |
| 12:00 pm - 12:25 pm | Leonard Guarente (Massachusetts Institute of Technology)
"SIR2, Calorie Restriction and Aging" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | TRANSCRIPTION |
| Discussion Leader: Bob Landick (University of Wisconsin-Madison) |
| 7:30 pm - 7:55 pm | Bob Landick (University of Wisconsin-Madison)
"Regulatory Dynamics in the RNA Polymerase Active Site" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Terence Strick (Institute Jacques Monod)
"The electrocardiogram of RNA polymerase: single-molecule studies of bacterial transcription" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Stephen Buratowski (Harvard Medical School)
"Coupling of transcription and mRNA processing" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Robert Singer (Albert Einstein College of Medicine)
"The dynamics of RNA synthesis and movement in living cells" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RIBOZYMES AND RIBOSWITCHES |
| Discussion Leader: Tina Henkin (Ohio State University) |
| 9:00 am - 9:25 am | Tina Henkin (Ohio State University)
"Sensing of metabolic signals by nascent RNAs" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:55 am | Dinsha Patel (Sloan Kettering Institute)
"Structural Biology of Riboswitches and RNA Silencing" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:25 am | Bill Scott (University of California at Santa Cruz)
"Distal tertiary interactions prime a ribozyme active site for acid-base catalysis: The 2.2Å resolution structure of a full-length hammerhead RNA" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:10 am - 11:35 am | Joseph Piccirilli (University of Chicago)
"Structure-function Relationships in Group I Introns" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 12:05 am | Ken Blout (Yale University)
"The guanine riboswitch--a new RNA target for antibacterial drug discovery?" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DNA REPLICATION, RECOMBINATION AND REPAIR |
| Discussion Leader: Virginia Zakian (Princeton University) |
| 7:30 pm - 7:55 pm | Virginia Zakian (Princeton University)
"Regulation of telomerase in baker's yeast" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Paul Modrich (Duke University Medical School)
"The role of MutL? in human mismatch repair" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | John A. Tainer (Scripps Research Institute)
"Integrated Solution and Crystal Structures of the 1000 Angstrom ABC ATPase Machine Acting in dsDNA Break Signaling and Repair Initiation" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Antoine van Oijen (Harvard Medical School)
"Single-molecule studies of phage T7 replication" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
