SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Lectures: Understanding and Using the Human Genome |
| Discussion Leaders: Leemor Joshua-Tor (HHMI / Cold Spring Harbor Laboratory) and Kristen W. Lynch (University of Texas Southwestern Medical Center) |
7:40 pm - 8:25 pm | Richard M. Myers (HudsonAlpha Institute for Biotechnology) "Global analysis of transcriptional regulation in human cells" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Robert Cook-Deegan (Duke University)
"Sharing and patenting data in nucleic acids research: norms, traditions, and expectations over time and in different fields" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Genome Integrity |
| Discussion Leader: Gregory L. Verdine (Harvard University) |
9:00 am - 9:25 am | Gregory L. Verdine (Harvard University)
"Interrogation, recognition and repair of damaged bases in DNA" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Short Presentation (TBA) |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Anja-Katrin Bielinsky (University of Minnesota)
"PCNA ubiquitination and checkpoint activation in DNA ligase I mutants" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Roland Kanaar (Erasmus Medical Center, The Netherlands)
"Mechanism of DNA repair by recombination" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Short Presentation (TBA) |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Hongtao Yu (University of Texas Southwestern Medical Center at Dallas)
"Chromosome segregation and the spindle checkpoint" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | John A. Tainer (The Scripps Research Institute)
"DNA End Recognition, Bridging, and Processing in Double-Strand-Break Repair" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Replication |
| Discussion Leader: Stephen P. Bell (HHMI / Massachusetts Institute of Technology) |
7:30 pm - 7:50 pm | Stephen P. Bell (HHMI / Massachusetts Institute of Technology)
"A Cascade of Kinases at the Origin: Multiple Kinases Activate the Mcm2-7 Helicase" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Michael Botchan (University of California, Berkeley)
"Activating the latent Drosophila MCM helicase" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Johannes Walter (Harvard Medical School)
"Mechanism of replication-coupled DNA interstrand cross-link repair" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | John Kuriyan (HHMI / University of California, Berkeley)
"Structural Analysis of Primer-Template Recognition by Clamp Loader Complexes" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Transcription and Chromatin Dynamics |
| Discussion Leader: Robert Kingston (Massachusetts General Hospital / Harvard Medical School) |
9:00 am - 9:25 am | Robert Kingston (Massachusetts General Hospital / Harvard Medical School)
"Analysis of chromatin dynamics over large regions of the genome" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Short Presentation (TBA) |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Nouria Hernandez (University of Lausanne, Switzerland)
"Regulation of RNA polymerase III transcription" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Karolin Luger (HHMI / Colorado State University)
"Posttranslational modifications as regulators of chromatin structure and histone chaperone function" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Short Presentation (TBA) |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Shelley L. Berger (The Wistar Institute)
"The complex language of histone post-translational modifications in genomic regulation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Ronald R. Breaker (HHMI / Yale University)
"Discovery and Analysis of Complex Bacterial Non-coding RNAs" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Post Transcriptional Regulation |
| Discussion Leader: Brenton R. Graveley (University of Connecticut Health Center) |
7:30 pm - 7:50 pm | Brenton R. Graveley (University of Connecticut Health Center)
"Analysis of Alternative Splicing Using Next-Generation Sequencing" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Tracy Johnson (University of California, San Diego) "Pre-messenger RNA processing and histone modification" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Holger Stark (Max-Planck Institute for Biophysical Chemistry, Germany)
"Structural Dynamics of spliceosomes and snRNPs by cryo-EM" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Robert B. Darnell (HHMI / The Rockefeller University) "RNA Brain Maps" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ncRNA: Diverse Effects on DNA and RNA |
| Discussion Leader: Gary Ruvkun (Massachusetts General Hospital / Harvard Medical School) |
9:00 am - 9:25 am | Gary Ruvkun (Massachusetts General Hospital / Harvard Medical School)
"The tiny RNA pathways of C. elegans" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Short Presentation (TBA) |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Janet F. Partridge (St. Jude Children's Research Hospital)
"Centromeric heterochromatin assembly in fission yeast" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Feng Guo (UCLA, School of Medicine) "Regulation of microRNA biogenesis by heme and the N-end rule pathway" |
10:45 am - 11:05 am | Discussion |
11:15 am - 11:25 am | Short Presentation (TBA) |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Alain Bucheton (Institute of Human Genetics, France)
"Heterochromatin and piRNAs in the control of retrotransposons and retroviruses in Drosophila" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Richard Gregory (Children's Hospital Boston, Harvard Medical School)
"Regulation of microRNA biogenesis in embryonic stem cells and cancer" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RNA Fate Decisions: Stability and Export |
| Discussion Leader: Lynne E. Maquat (University of Rochester Medical Center) |
7:30 pm - 7:50 pm | Lynne E. Maquat (University of Rochester Medical Center)
"Regulation of mammalian gene expression through mechanisms of mRNA decay" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Jeremy Sanford (University of California, Santa Cruz)
"Surveying the RNA landscape recognized by splicing factor SFRS1" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Christopher D. Lima (Memorial Sloan-Kettering Cancer Center)
"Structural studies of RNA processing and decay" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | David L. Spector (Cold Spring Harbor Laboratory)
"Long Nuclear Retained Non-coding RNAs" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ribosome Biogenesis, Function, and Regulation |
| Discussion Leader: Rachel Green (HHMI Johns Hopkins University School of Medicine) |
9:00 am - 9:25 am | Rachel Green (HHMI Johns Hopkins University School of Medicine)
"Quality control by the ribosome following peptide bond formation" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Short Presentation (TBA) |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Taekjip Ha (HHMI / University of Illinois at Urbana-Champaign)
"Single Molecule Analysis of Molecular Motors Moving on RNA" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Juli Feigon (University of California, Los Angeles) "A tail of two pseudoknots" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Harry F. Noller (University of California, Santa Cruz)
"Ribosome Structure and Movement" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session IV |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RNA Catalysis |
| Discussion Leader: Anna Marie Pyle (HHMI / Yale University) |
7:30 pm - 7:50 pm | Anna Marie Pyle (HHMI / Yale University) "Group II intron crystal structures reveal new levels of RNA architectural complexity" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Samuel E. Butcher (University of Wisconsin-Madison)
"RNA-protein interactions that drive spliceosome assembly" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Joseph A. Piccirilli (HHMI / The University of Chicago)
"The Catalytic Mechanism of Nuclear Premessenger RNA Splicing by the Splicesome" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Saba Valadkhan (Case Western Reserve University)
"Non-coding RNAs as the dark matter of the genome: lessons from the spliceosome and neurogenesis" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |