SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Lectures |
| Discussion Leaders: Chris Lima (Sloan-Kettering Institute) and Roland Kanaar (Erasmus University) |
7:40 pm - 8:25 pm | Carlos Bustamante (University of California, Berkeley)
"Recent advances in single molecule biophysics" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Venki Ramakrishnan (MRC Laboratory of Molecular Biology)
"Structural basis of decoding by the ribosome" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Transcription and Chromatin Dynamics |
| Discussion Leader: Danesh Moazed (Harvard) |
9:00 am - 9:25 am | Danesh Moazed (Harvard Medical School) "RNA scaffolds as sensors of the epigenome" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Short Presentation: David Weinberg (MIT)
"The inside-out mechanism of Dicers from budding yeast" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Karolin Luger (Colorado State University) "Modulators of nucleosome and chromatin structure" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Douglas Koshland (University of California, Berkeley) "When RNA goes rogue" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Short Presentation: Andrew Bosson (MIT)
"miRNA-dependent and -independent binding of Argonaute2 to mRNAs" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Michelle Wang (Cornell University) "Single molecule studies of the DNA unwinding mechanism of a ring-shaped helicase" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Stephen Buratowski (Harvard Medical School) "Coordinating different stages of RNA polymerase II transcription" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ribosome Biogenesis, Function, and Regulation |
| Discussion Leader: Venki Ramakrishnan (MRC Laboratory of Molecular Biology) |
7:30 pm - 7:50 pm | Rachel Green (Johns Hopkins University) "Quality control on the ribosome during translation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Jamie Williamson (Scripps Research Institute)
"Dynamics of the ribosome assembly in vitro and in cells" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Nenad Ban (ETH Zurich) "Crystallography of Eukaryotic Ribosomes: Insights into the Initiation of Translation" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Joseph Puglisi (Stanford University School of Medicine) "Dynamics of translation" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Non-coding RNA |
| Discussion Leader: Joan Steitz (Yale University) |
9:00 am - 9:25 am | Joan Steitz (Yale University) "Non-coding RNAs: with a viral twist" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Short Presentation: Katrin Karbstein (Scripps Florida)
"Structural and Functional Dissection of Cytoplasmic 40S Ribosome Assembly" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Christian Spahn (Charité - Universitätsmedizin Berlin)
"Visualizing conformational modes of ribosomal complexes by multiparticle cyro-electron microscopy" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Sandra Wolin (Yale University)
"Non-coding RNA degradation" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Short Presentation: Saibal Chatterjee (Friedrich Miescher Institute)
"From miRNA turnover to maintenance of active miRISC" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Blake Wiedenheft (University of California, Berkeley)
"RNA-guided adaptive immunity in bacteria" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Dinshaw Patel (Sloan-Kettering Institute) "Structural biology of RNA-mediated gene regulation" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Replication |
| Discussion Leader: James Berger (University of California, Berkeley) |
7:30 pm - 7:50 pm | James Berger (University of California, Berkeley) "Molecular mechanisms for initiating DNA replication" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Catherine Fox (University of Wisconsin) "Combining yeast genetics and genomics to reveal how DNA replication origins are chosen within the context of chromatin" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Michael Botchan (University of California, Berkeley) "Regulating the activity of the MCM helicase" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Peter Burgers (Washington University in St. Louis) "Metal binding clusters in eukaryotic B-family DNA polymerases mediate subunit interactions and replication processivity" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genome Integrity |
| Discussion Leader: Wolf Heyer (University of California, Davis) |
9:00 am - 9:25 am | Wolf Heyer (University of California, Davis) "Mechanisms of regulating homologous recombination" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Short Presentation: Derek Lyons (University of Michigan)
"Human DNA glycosylases initiate deletion of unpaired lesions" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Dana Branzei (IFOM) "BLM/Sgs1-mediated dissolution is uncoupled from Mus81-dependent resolution of template switch intermediates" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Group Photo / Coffee Break |
10:45 am - 11:05 am | Joyce Lebbink (Erasmus MC, Dept. Genetics)
"Molecular mechanism of daughter strand incision during DNA mismatch repair" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Short Presentation: Michael Trakselis (University of Pittsburgh)
"A multifaceted oligomeric DNA replication polymerase with unique terminal transfer properties" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Scott Keeney (Sloan-Kettering Institute) "Mechanism and regulation of meiotic recombination initiation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Alan D'Andrea (Dana-Farber Cancer Institute; Harvard Medical School) "Assembly of the Fanconi Anemia proteins at the replication fork" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RNA Stability and Export |
| Discussion Leader: Elena Conti (Max Planck Institute, Martinsried) |
7:30 pm - 7:50 pm | Elena Conti (Max Planck Institute, Martinsried) "Molecular mechanisms of RNA degradation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Lynne E. Maquat (University of Rochester School of Medicine and Dentistry) "IncRNAs transactivate mRNA decay via Alu element-mediated base-pairing" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Jeff Coller (Case Western Reserve University) "Decapping of coding and non-coding RNAs" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Allan Jacobson (University of Massachusetts Medical School) "Interrelationships of mRNA decay and translation in yeast" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:45 am | Co- and Post-Transcriptional Regulation |
| Discussion Leader: Brenton R. Graveley (University of Connecticut Health Center) |
9:00 am - 9:25 am | Brenton R. Graveley (University of Connecticut Health Center) "Genome wide analysis of mRNA processing in Drosophila" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Short Presentation: Wendy Gilbert (MIT)
"Reconsidering movement of eukaryotic mRNAs between polysomes and P-bodies" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Tracy Johnson (University of California, San Diego) "RNA processing and histone modification" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Christine Mayr (Sloan-Kettering Institute) "Transcriptome diversity due to alternative cleavage and polyadenylation during cancer pathogenesis" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Alain Jacquier (Institut Pasteur) "Pervasive transcription at stationary phase in yeast" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session IV |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Nucleic Acid Structure and Catalysis |
| Discussion Leader: Jamie Cate (University of California, Berkeley) |
7:30 pm - 7:50 pm | Jamie Cate (University of California, Berkeley)
"Structures of the ribosome in classical and hybrid states of tRNA binding" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Hashim Al-Hashimi (University of Michigan) "Transient Hoogsteen base-pairs in canonical duplex DNA" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Sarah Woodson (Johns Hopkins University) "RNA folding and 30S ribosome assembly" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Anna Marie-Pyle (Yale University) "Structural features and assembly pathways for large, multidomain RNA molecules" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |