SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Lecture: Recent Biochemical and Structural Approaches to Deciphering the Mechanisms of Protein Synthesis |
| Discussion Leader: Karolin Luger (Colorado State University) |
7:40 pm - 8:25 pm | Harry Noller (University of California, Santa Cruz)
"Ribosome structure and dynamics"
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8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | James Berger (Johns Hopkins University)
"Molecular mechanisms for initiating DNA replication"
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9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genome Integrity and DNA Repair |
| Discussion Leader: Lorena Beese (Duke University Medical Center) |
9:00 am - 9:20 am | Lorena Beese (Duke University Medical Center)
"Conformational changes that drive the human DNA repair machinery"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sylvie Doublie (University of Vermont)
"Visualizing DNA Repair Enzymes Encountering Free Radical DNA Lesions"
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9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Wolf-Dietrich Heyer (University of California, Davis)
"Mechanism and regulation of recombinational DNA repair"
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10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Thomas Kunkel (NIH/NIEHS)
"Ribonucleotide Incorporation During DNA Replication And Its Consequences"
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11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Roland Kanaar (Erasmus Medical Center)
"DNA damage repair and anti-cancer treatment"
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11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Rafael Fernandez Leiro (MRC - Laboratory of Molecular Biology)
"Roles of the exonuclease epsilon in DNA synthesis and repair"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Brandt Eichman (Vanderbilt University)
"Structural basis for DNA junction preference by a conserved nucleic acid binding domain"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ribosome Function and Regulation |
| Discussion Leader: Alan Hinnebusch (NIH/NICHD) |
7:30 pm - 7:50 pm | Alan Hinnebusch (NIH/NICHD)
"Dynamic interactions controlling start codon recognition in eukaryotic translation initiation"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Claes Gustafsson (DNA 2.0)
"Systematic analysis of the impact of noncoding variables in the open reading frame"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Allen Buskirk (Brigham Young University)
"Nascent Peptides that Stall Ribosomes During Protein Synthesis"
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8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Kurt Fredrick (Ohio State University)
"Learning from ribosomes that make mistakes"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chromatin Structure and Dynamics |
| Discussion Leader: Geeta Narlikar (University of California, San Francisco) |
9:00 am - 9:20 am | Geeta Narlikar (University of California, San Francisco)
"Molecular Mechanisms of Heterochromatin Assembly"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Job Dekker (U Mass Medical)
"Roles of Chromosome compartmentalization and Looping in gene regulation"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Tom Owen-Hughes (University of Dundee)
"Combined approaches for studying the function of the nucleosome spacing enzyme Chd1"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Yawen Bai (NIH, National Cancer Institute)
"Methyl-based NMR analysis of nucleosome recognition"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Craig Peterson (U Mass Medical)
"Chromatin dynamics: Putting histones in their place"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Ozan Aygun (National Cancer Institute, USA)
"Mechanisms enforcing epigenetic stability of heterochromatin domains"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Maxim Imakaev (Massachusetts Institute of Technology)
"Metaphase Chromosome Organization: From Hi-C Data to Polymer Models"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RNA Processing, Export and Decay |
| Discussion Leader: Melissa Moore (U Mass Medical) |
7:30 pm - 7:50 pm | Melissa Moore (U Mass Medical)
"Assembly and dynamics of uber complex RNPs"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Tao Pan (University of Chicago)
"Adaptive translation as a mechanism of stress response and adaptation"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Guillaume Chanfreau (University of California, Los Angeles)
"Widespread and regulated use of non-productive splice sites in S. cerevisiae"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Sean Ryder (U Mass Medical)
"Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Non-coding RNA |
| Discussion Leader: Brenda Bass (University of Utah) |
9:00 am - 9:20 am | Brenda Bass (University of Utah)
"The dsRNAome and its functions"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | John Rinn (Harvard Medical School/Broad Institute)
"Linking RNA to Mammalian Development and Disease"
|
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Ian MacRae (The Scripps Research Institute)
"Structure and Mechanism of Human Argonaute-2"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Jon Staley (University of Chicago)
"Establishing Fidelity in Pre-mRNA Splicing"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Wojciech Galej (MRC Laboratory of Molecular Biology)
"Crystal structure of Prp8 and its implications for the spliceosomal active site"
|
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Julian Chen (Arizona State University)
"The 3' end biogenesis of telomerase RNA by novel RNA structures"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Neha Gupta (University of Rochester)
"Identification and characterization of small subunit ribosomal assembly intermediates"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Liana Lareau (UC Santa Cruz)
"Distinct ribosome states revealed by sequencing of ribosome-protected mRNA fragments"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Nucleic Acid Structure and Catalysis |
| Discussion Leader: Adrian Ferre D'Amare (NIH/NHLBI) |
7:30 pm - 7:50 pm | Adrian Ferre D'Amare (NIH/NHLBI)
"A single active site nucleotide confers coenzyme-dependent catalysis to the glmS riboswitch-ribozyme"
|
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Ilya Finkelstein (University of Texas at Austin)
"Molecular Traffic Jams on DNA: A Single Molecule Perspective"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Nils Walter (University of Michigan)
"Pre-mRNA in the driver's seat: Substrate remodeling during splicing, one step and one molecule at a time"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Christine Dunham (Emory University)
"Structural studies of ribosome-dependent toxins active during the stringent response"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Co- and Post- Transcriptional Regulation |
| Discussion Leader: David Bentley (University of Colorado, Denver) |
9:00 am - 9:20 am | David Bentley (University of Colorado, Denver)
"Integration of transcription elongation and termination with mRNA processing"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Elena Conti (Max Planck Institute)
"Molecular mechanisms of RNA-dependent ATPases" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Manny Ares (University of California, Santa Cruz)
"Competition between pre-mRNAs for a limiting splicing apparatus drives global changes in splicing"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Chris Lima (Sloan-Kettering Institute)
"RNA decay activities of the eukaryotic RNA exosome"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Eric Phizicky (University of Rochester)
"tRNA quality control: what's a tRNA, and what's not" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Albert Weixlbaumer (The Rockefeller University)
"Structural basis for transcriptional pausing in bacteria"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Michael Trakselis (University of Pittsburgh)
"Assembly and Distributive Action of the Archaeal DNA Polymerase Holoenzyme"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Replication |
| Discussion Leader: James Berger (Johns Hopkins University) |
7:30 pm - 7:40 pm | Simon Phillips (Research Complex at Harwell)
"Structural Studies of Rolling Circle Replication Initiator Proteins"
|
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Justin Peters (Mayo Clinic College of Medicine)
"Chemical manipulation of DNA mechanical properties"
|
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Luca Pellegrini (University of Cambridge)
"Priming DNA synthesis in eukaryotic replication"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Xiaojiang Chen (University of Southern California)
"MCM Changes DNA Topology, a Function Not Related to Unwinding"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Stephen P. Bell (MIT)
"Mechanisms Controlling the Initiation of Eukaryotic DNA Replication"
|
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |