Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Genomic Engineering and Regulation
The keynote speaker is Professor Jennifer Doudna (HHMI / UC Berkeley).
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:35 pm
"RNA-Guided Immunity: CRISPR Biology and the Future of Genome Engineering"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Integrity
and DNA Repair
9:00 am - 9:20 am
"The DNA Damage Response in Cancer Treatments"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"SMX and GEN1 Endonucleases Resolve Sister Chromatid Bridges to Ensure Chromosome Segregation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"DNA Sculpting and the Specificity of DNA Repair Machines"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Base Excision Repair of DNA Interstrand Crosslinks"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Activation of a DNA Mismatch Repair Endonuclease that Acts in Meiotic Crossing Over"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mechanism of Homologous Recombination and Crossover Control"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Changing the Transcriptome: RNA Editing and Modification
7:30 pm - 7:50 pm
"ADARs, Dicer and the dsRNAome"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"RNA Methylation in Gene Expression Regulation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Translation Regulation by Dynamic mRNA Methylation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Taking RNA in a New Direction: 3'-5' Polymerases in Biology"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Heme-Mediated Regulation of microRNA Processing"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
DNA Replication and Transcription
9:00 am - 9:20 am
"Structural Mechanisms of Nucleic-Acid Dependent Machines"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Opening and Closing the Mcm2-7 Ring During Origin Licensing"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"The Bacterial Replisome Caught in the Act by Cryo-EM"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"RecQ4 - The Odd One out in the RecQ Helicase Family"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Structural Mechanisms of Swi2/Snf2 Remodelling Enzymes"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mechanistic Insights into Eukaryotic Transcription Initiation from Cryo-EM Studies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of Translation: Starts, Stops, and Pauses
7:30 pm - 7:50 pm
"Molecular Mechanism of Scanning and Start Codon Selection in Translation Initiation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Human eIF3: The Mediator of Translation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Visualization of Translation by Ensemble Cryo-EM"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Adjacent Codons Act in Concert to Modulate Translation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Structural Basis of Co-Translational Quality Control"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Noncoding RNAs (ncRNAs) and Defense Mechanisms
9:00 am - 9:20 am
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structure-Based Discovery of New Functions in Large RNAs"
9:50 am - 10:00 am
Discussion
10:00 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Molecular Architecture of Long Noncoding RNAs"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Methyltransferase-Like Protein 16 Binds the 3'-Terminal Triple Helix of MALAT1 Long Noncoding RNA"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Developmental and Physiological Function of circRNAs"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Mechanisms of tRNA Splicing and tRNA Repair"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Telomerase and Maintenance of Telomere Length Equilibrium"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Integrative Structural Biology of Telomerase"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Telomerase Innovations for Telomeric Repeat Synthesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Pif1 Family Helicases: Maestros at Bypassing Hard-to-Replicate Sites"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Eukaryotic Replication Fork
9:00 am - 9:20 am
"Structure and Mechanism of the Eukaryotic Replication Fork"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Reconstitution of Eukaryotic Chromosome Replication with Purified Proteins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Dynamic Interactions at the Eukaryotic Replication Fork"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"rNTP Incorporation During Nuclear DNA Replication in Yeast and Its Consequences"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Nucleotide Pools Dictate the Identity and Frequency of Ribonucleotide Incorporation in Mitochondrial DNA"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Activities of ssDNA Binding Proteins in Maintaining Replication Fork Stability"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Conflict Between CRISPR Interference and DNA Replication as a Trigger for CRISPR Adaptation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Expression and Regulation in Disease
7:30 pm - 7:55 pm
"RNA Quality Control by the Nuclear RNA Exosome"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Dense Mutational Interrogation to Untangle Functions of Factors Comprising a Complex Essential System, the Human RNA Exosome"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Chemical and Structural Bias in Small:Molecule RNA Recognition"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"LARP1 Regulates Translation of the Translation Apparatus"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"mRNA Splicing and Disease"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure