Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Genomic Engineering and Regulation
The keynote speaker is Professor Jennifer Doudna (HHMI / UC Berkeley).
Discussion Leader: Brenda Bass (University of Utah, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:35 pm
Jennifer Doudna (University of California, Berkeley / Howard Hughes Medical Institute, USA)
"RNA-Guided Immunity: CRISPR Biology and the Future of Genome Engineering"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Ronald Breaker (Yale University, USA)
"Orphan Riboswitches"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Integrity
and DNA Repair
Discussion Leader: James Berger (Johns Hopkins School of Medicine, USA)
9:00 am - 9:20 am
Roland Kanaar (Erasmus Medical Center, The Netherlands)
"The DNA Damage Response in Cancer Treatments"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stephen West (Francis Crick Institute, United Kingdom)
"SMX and GEN1 Endonucleases Resolve Sister Chromatid Bridges to Ensure Chromosome Segregation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
John Tainer (University of Texas MD Anderson Cancer Center, USA)
"DNA Sculpting and the Specificity of DNA Repair Machines"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Brandt Eichman (Vanderbilt University, USA)
"Base Excision Repair of DNA Interstrand Crosslinks"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Eric Alani (Cornell University, USA)
"Activation of a DNA Mismatch Repair Endonuclease that Acts in Meiotic Crossing Over"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Wolf-Dietrich Heyer (University of California, Davis, USA)
"Mechanism of Homologous Recombination and Crossover Control"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Jane Jackman (Ohio State University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Changing the Transcriptome: RNA Editing and Modification
Discussion Leader: Kevin Weeks (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:50 pm
Brenda Bass (University of Utah, USA)
"ADARs, Dicer and the dsRNAome"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Chuan He (University of Chicago, USA)
"RNA Methylation in Gene Expression Regulation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Selected from Poster Abstracts: Kate Meyer (Duke University, USA)
"Translation Regulation by Dynamic mRNA Methylation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Jane Jackman (Ohio State University, USA)
"Taking RNA in a New Direction: 3'-5' Polymerases in Biology"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Yunsun Nam (University of Texas Southwestern Medical Center, USA)
"Heme-Mediated Regulation of microRNA Processing"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
DNA Replication and Transcription
Discussion Leader: Luca Pellegrini (University of Cambridge, United Kingdom)
9:00 am - 9:20 am
James Berger (Johns Hopkins School of Medicine, USA)
"Structural Mechanisms of Nucleic-Acid Dependent Machines"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stephen P. Bell (Howard Hughes Medical Institute / Massachusetts Institute of Technology, USA)
"Opening and Closing the Mcm2-7 Ring During Origin Licensing"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Meindert Lamers (Medical Research Council, United Kingdom)
"The Bacterial Replisome Caught in the Act by Cryo-EM"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Caroline Kisker (University of Wuerzburg, Germany)
"RecQ4 - The Odd One out in the RecQ Helicase Family"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Karl-Peter Hopfner (Ludwig Maximilian University of Munich, Germany)
"Structural Mechanisms of Swi2/Snf2 Remodelling Enzymes"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Eva Nogales (University of California, Berkeley, USA)
"Mechanistic Insights into Eukaryotic Transcription Initiation from Cryo-EM Studies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation of Translation: Starts, Stops, and Pauses
Discussion Leader: Anna Marie Pyle (Yale University, USA)
7:30 pm - 7:50 pm
Alan Hinnebusch (National Institutes of Health, USA)
"Molecular Mechanism of Scanning and Start Codon Selection in Translation Initiation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jamie Cate (University of California, Berkeley, USA)
"Human eIF3: The Mediator of Translation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Selected from Poster Abstracts: Andrei Korostelev (University of Massachusetts Medical School, USA)
"Visualization of Translation by Ensemble Cryo-EM"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Elizabeth Grayhack (University of Rochester Medical Center, USA)
"Adjacent Codons Act in Concert to Modulate Translation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Hong Jin (University of Illinois at Urbana-Champaign, USA)
"Structural Basis of Co-Translational Quality Control"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Noncoding RNAs (ncRNAs) and Defense Mechanisms
Discussion Leader: Christopher Lima (Structural Biology Program, Sloan Kettering Institute, USA)
9:00 am - 9:20 am
David Bartel (Massachusetts Institute of Technology, USA)
"MicroRNAs"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kevin Weeks (University of North Carolina at Chapel Hill, USA)
"Structure-Based Discovery of New Functions in Large RNAs"
9:50 am - 10:00 am
Discussion
10:00 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Anna Marie Pyle (Yale University, USA)
"Molecular Architecture of Long Noncoding RNAs"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Selected from Poster Abstracts: Jessica Brown (University of Notre Dame, USA)
"Methyltransferase-Like Protein 16 Binds the 3'-Terminal Triple Helix of MALAT1 Long Noncoding RNA"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Sebastian Kadener (The Hebrew University of Jerusalem, Israel)
"Developmental and Physiological Function of circRNAs"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Stewart Shuman (Memorial Sloan Kettering Cancer Center, USA)
"Mechanisms of tRNA Splicing and tRNA Repair"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Telomeres and Telomerase
Discussion Leader: Stephen P. Bell (Howard Hughes Medical Institute / Massachusetts Institute of Technology, USA)
7:30 pm - 7:50 pm
Carol Greider (Johns Hopkins University, USA)
"Telomerase and Maintenance of Telomere Length Equilibrium"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Juli Feigon (University of California, Los Angeles, USA)
"Integrative Structural Biology of Telomerase"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Kathleen Collins (University of California, Berkeley, USA)
"Telomerase Innovations for Telomeric Repeat Synthesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Virginia Zakian (Princeton University, USA)
"Pif1 Family Helicases: Maestros at Bypassing Hard-to-Replicate Sites"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Eukaryotic Replication Fork
Discussion Leader: Virginia Zakian (Princeton University, USA)
9:00 am - 9:20 am
Mike O'Donnell (Rockefeller University, USA)
"Structure and Mechanism of the Eukaryotic Replication Fork"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Dirk Remus (Memorial Sloan Kettering Cancer Center, USA)
"Reconstitution of Eukaryotic Chromosome Replication with Purified Proteins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Luca Pellegrini (University of Cambridge, United Kingdom)
"Dynamic Interactions at the Eukaryotic Replication Fork"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Thomas Kunkel (National Institute of Environmental Health Sciences, NIH, USA)
"rNTP Incorporation During Nuclear DNA Replication in Yeast and Its Consequences"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Anders Clausen (University of Gothenburg, Sweden)
"Nucleotide Pools Dictate the Identity and Frequency of Ribonucleotide Incorporation in Mitochondrial DNA"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
David Cortez (Vanderbilt University School of Medicine, USA)
"Activities of ssDNA Binding Proteins in Maintaining Replication Fork Stability"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Edward Bolt (University of Nottingham, United Kingdom)
"Conflict Between CRISPR Interference and DNA Replication as a Trigger for CRISPR Adaptation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Expression and Regulation in Disease
Discussion Leader: Jane Jackman (Ohio State University, USA)
7:30 pm - 7:55 pm
Christopher Lima (Structural Biology Program, Sloan Kettering Institute, USA)
"RNA Quality Control by the Nuclear RNA Exosome"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Selected from Poster Abstracts: Andrei Alexandrov (Yale University School of Medicine, USA)
"Dense Mutational Interrogation to Untangle Functions of Factors Comprising a Complex Essential System, the Human RNA Exosome"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Selected from Poster Abstracts: Amanda Hargrove (Duke University, USA)
"Chemical and Structural Bias in Small:Molecule RNA Recognition"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Selected from Poster Abstracts: Andrea Berman (University of Pittsburgh, USA)
"LARP1 Regulates Translation of the Translation Apparatus"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Adrian Krainer (Cold Spring Harbor Laboratory, USA)
"mRNA Splicing and Disease"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure