Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Telomeres and the DNA Damage Response
Discussion Leader: Jayakrishnan Nandakumar (University of Michigan, Ann Arbor, USA)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:50 pm
Titia de Lange (The Rockefeller University, USA)
"Telomeres and the DNA Damage Response"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nucleic Acids in Immunity
Discussion Leader: Wei Yang (National Institutes of Health, USA)
9:00 am - 9:20 am
Zhijian Chen (University of Texas Southwestern Medical Center, USA)
"The cGAS-STING Pathway of Cytosolic DNA Sensing and Signaling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Martin Jinek (University of Zurich, Switzerland)
"Structural and Mechanistic Insights into RNA-Guided CRISPR Immunity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Brenda Bass (University of Utah, USA)
"Divergent Roles of Dicer's Helicase Domain in Antiviral Defense"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Anna Marie Pyle (Yale University, USA)
"Designing Potent RNA Agonists for Activating the RIG-I Receptor"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Bruce Sullenger (Duke University, USA)
"Combating Cancer and Clots with RNA-Based and RNA-Targeted Therapeutics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
James Eaglesham (Harvard Medical School / Dana-Farber Cancer Institute, USA)
"Viral and Metazoan Poxins Are cGAMP-Specific Nucleases that Restrict cGAS-STING Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Cristhian Cadena (Program in Virology, Harvard Medical School, USA)
"Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Kathleen Collins (University of California, Berkeley, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ribosome Assembly and Function
Discussion Leader: Lynne Maquat (University of Rochester Medical Center, USA)
7:30 pm - 7:50 pm
Sebastian Klinge (Rockefeller University, USA)
"Nucleolar Stages of Eukaryotic Ribosome Assembly"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Scott Blanchard (Weill Cornell Medicine, USA)
"Variant Ribosomal RNA Alleles Are Conserved, Exhibit Context-Specific Expression and Regulate Gene Expression"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Hani Zaher (Washington University in St. Louis, USA)
"Chemical Damage and Ribosome-Based Quality-Control Processes"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Nicholas Ingolia (University of California, Berkeley, USA)
"Cas9-Induced DNA Double-Strand Breaks Trigger Ribosome Remodeling and Translational Shutdown"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transcriptional Regulation and Coupling to RNA Fate
Discussion Leader: Christopher Lima (Sloan Kettering Institute / Howard Hughes Medical Institute, USA)
9:00 am - 9:20 am
Karen Adelman (Harvard Medical School, USA)
"Differential Regulation of Transcriptional Elongation and RNA Processing at Non-Coding RNA Loci"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Frederic Chedin (University of California, Davis, USA)
"Single Molecule and Modeling Approaches Reveal Principles of R-Loop Formation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Lori Passmore (MRC Laboratory of Molecular Biology, United Kingdom)
"Mechanistic Insights into the Eukaryotic mRNA Poly(A) Tail Machinery"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Karla Neugebauer (Yale University, USA)
"How Splicing Regulation Is Coupled to Transcription"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Dale Wigley (Imperial College London, United Kingdom)
"Swr1 and INO80 Complexes: Chromatin Modifying Machines"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Iestyn Whitehouse (Memorial Sloan-Kettering Cancer Center, USA)
"Coordination of Transcription and DNA Replication in C. elegans "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organization of the Genome in Three Dimensions and Dynamic Genome Rearrangements
Discussion Leader: Iestyn Whitehouse (Memorial Sloan-Kettering Cancer Center, USA)
7:30 pm - 7:50 pm
Christian Haering (European Molecular Biology Laboratory (EMBL), Germany)
"Genome Organization by SMC Protein Complexes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Wei Yang (National Institutes of Health, USA)
"Structural Insights into DNA Pairing and Cleavage by RAG1/2"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Phoebe Rice (University of Chicago, USA)
"Mobile Element Replication-Related Machinery: What Does It Do and Why?"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Donald Rio (University of California, Berkeley, USA)
"P Element Transposons in Drosophila and Vertebrates"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Integrity: Replication and Recombination
Discussion Leader: Lorena Beese (Duke University School of Medicine, USA)
9:00 am - 9:20 am
Wolf-Dietrich Heyer (University of California, Davis, USA)
"Dynamic Quality Control and Pathway Reversibility During Homologous Recombination"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Scott Williams (National Institutes of Health, USA)
"Enforcement of DNA Ligation Fidelity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Jayakrishnan Nandakumar (University of Michigan, Ann Arbor, USA)
"Recruitment of Human Telomerase to Telomeres"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Thi Hoang Duong Nguyen (University of California, Berkeley, USA)
"Replenishing the Ends: Structural Mechanism of Human Telomerase"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
James Berger (Johns Hopkins University School of Medicine, USA)
"Mechanisms for Initiating DNA Replication"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Lyle Simmons (University of Michigan, USA)
"Genome Instability Caused by Persistent RNA-DNA Hybrid Formation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Genome Integrity: Damage Recognition, Avoidance and Repair
Discussion Leader: Wolf-Dietrich Heyer (University of California, Davis, USA)
7:30 pm - 7:50 pm
Lorena Beese (Duke University School of Medicine, USA)
"DNA Repair Machines"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Ivan Ahel (University of Oxford, United Kingdom)
"ADP-Ribosylation Signaling in Regulation of Genome Stability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Brandt Eichman (Vanderbilt University, USA)
"Structural Insights into DNA Repair at Stalled Replication Forks"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Sylvie Doublie (University of Vermont, USA)
"Functional Significance of Conformational Flexibility in DNA Repair Enzymes"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RNA Quality Control
Discussion Leader: Karen Adelman (Harvard Medical School, USA)
9:00 am - 9:20 am
Mike Kiledjian (Rutgers University, USA)
"NAD+ in the Control of RNA Turnover"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lynne Maquat (University of Rochester Medical Center, USA)
"Transcriptional Coactivator PGC-1alpha Contains a Novel CBP80-Binding Motif that Orchestrates Efficient Target Gene Expression"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Christopher Lima (Sloan Kettering Institute / Howard Hughes Medical Institute, USA)
"Nuclear Quality Control: Cofactors of the RNA Exosome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Eric Phizicky (University of Rochester School of Medicine, USA)
"A New Pathway of Pre-tRNA Surveillance"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Samantha Dodbele (The Ohio State University, USA)
"An Orphan 3'-5' Polymerase Implicated in Noncoding RNA Processing"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Monica Pillon (National Institute of Environmental Health Sciences, NIH, USA)
"Active Site Coordination Within a Multienzyme Pre-rRNA Processing Complex"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Bobby Hogg (National Heart, Lung, and Blood Institute, NIH, USA)
"PTBP1 Promotes ATPase-Dependent Dissociation of UPF1 from mRNPs to Prevent Nonsense Mediated Decay"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Nilisha Pokhrel (Marquette University, USA)
"Replication Protein A: Interplay Between the DNA Binding Domains and Its Functional Significance"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Biological and Therapeutic Impact of Nucleic Acid Modifications
Discussion Leader: Brenda Bass (University of Utah, USA)
5:30 pm - 5:50 pm
Joshua Rosenthal (Marine Biological Laboratory, University of Chicago, USA)
"Temporal and Spatial Dynamics of High-Level mRNA Editing in Cephalopods"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Jeremy Wilusz (University of Pennsylvania, USA)
"Circular RNAs and Other Unexpected Outputs of Protein-Coding Genes"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Kathy Fange Liu (The University of Pennsylvania, USA)
"Transcriptome-Wide Mapping and Functional Study of N3-Methylcytosine Methylome in Polyadenylated RNA"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Kristin Koutmou (University of Michigan, USA)
"mRNA Modifications Alter Translation Elongation and Fidelity"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Yuan Yang (University of California, Los Angeles, USA)
"Structural Basis of 7SK RNA 5'-Gamma-Phosphate Methylation and Retention by MePCE"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Richard Pomerantz (Lewis Katz School of Medicine, Temple University, USA)
"Molecular Basis of Microhomology-Mediated End-Joining by Purified Full-Length Pol-Theta"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure