Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Frontiers in Nucleic Acid Science
Discussion Leader: Philip Kranzusch (Dana-Farber Cancer Institute, United States)
7:40 pm - 8:25 pm
Andrei Korostelev (UMass Chan Medical School, United States)
"Ribosome as a Trigger of Intra- and Extra-Cellular Stress Responses"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Agata Smogorzewska (The Rockefeller University, United States)
"The role of Replisome-Associated RTF2 in Ribonucleotide Dynamics"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Re-engineering the Central Dogma
Discussion Leader: Samuel Sternberg (Columbia University, United States)
9:00 am - 9:20 am
Chang Liu (University of California, Irvine, United States)
"Experimental Evolution of Chosen Genes near their Mutational Speed Limits"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Farren Isaacs (Yale University, United States)
"Genomes by Design: Recoding and Rewriting Life's Genetic Blueprint"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Yamuna Krishnan (University of Chicago, United States)
"Chemically Mapping Organelles with DNA"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
David Lilley (University of Dundee, United Kingdom)
"RNA - A Natural Source of Nanotechnology Building Blocks"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Nikolaos Papastavrou (The Salk Institute for Biological Studies, United States)
"RNA-Catalyzed Evolution of a Ribozyme"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Markos Koutmos (University of Michigan, United States)
"Structure and Substrate Selection by Eukaryotic Pseudouridine Synthases"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Sigrid Nachtergaele (Yale University, United States)
"New methods to Measure and map RNA Modifications"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Anthony Mustoe (Baylor College of Medicine, United States)
"Comprehensive Analysis of RNA and RNP Higher-Order Architecture by Multi-Site Enhanced DMS Probing"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Jane Jackman (Ohio State University, United States) and Brandt Eichman (Vanderbilt University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA and DNA Viruses
Discussion Leader: Stewart Shuman (Memorial Sloan Kettering Cancer Center, United States)
7:30 pm - 7:50 pm
Andrea Gamarnik (Fundación Instituto Leloir, Argentina)
"Flavivirus RNA Structures Modulate Innate Immune Responses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Philip Kranzusch (Dana-Farber Cancer Institute, United States)
"Evolution and Evasion of Antiviral Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Kristen Lynch (University of Pennsylvania, United States)
"Alternative RNA Processing in the Human Immune Response"
8:50 pm - 9:00 pm
Discussion
9:10 pm - 9:20 pm
John Smolka (University of California, Berkeley, United States)
"Investigating an Intersection of Genome Replication and tRNA Aminoacylation in Human Mitochondria"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:35 pm
Eric Strobel (State University of New York at Buffalo, United States)
"Systematic Evaluation of Cotranscriptional RNA Folding Mechanisms using an RNA-Dependent DNA Partitioning Assay"
9:35 pm - 9:40 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nucleic Acid Processing Machines: Regulation and Structure
Discussion Leader: Rui Zhao (University of Colorado Anschutz Medical Campus, United States)
9:00 am - 9:20 am
Yuan He (Northwestern University, United States)
"Structural Basis of DNA Double-Strand Break Repair by NHEJ"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Yunsun Nam (University of Texas Southwestern Medical Center, United States)
"From Cutting to Chemical Modifications—How Proteins Recognize Substrate RNAs"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ailong Ke (Cornell University, United States)
"Beyond RNA-Guided Nucleases: RNA-Guided Protease Activation in CRISPR-Cas"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Caroline Kisker (University of Würzburg, Germany)
"The "Other" Side of XPD"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Zhi Zheng (Memorial Sloan Kettering Cancer Center, United States)
"Structural Insights into the Mechanism of DNA Binding and Cleavage by Spo11"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Gina Buchel (Thomas Jefferson University, United States)
"Structural Basis for DNA Proofreading"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jessica Wojtaszek (NIH/NIEHS, United States)
"Structure-Specific roles for PolG2-DNA Complexes in Maintenance and Replication of Mitochondrial DNA"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Srinivas Somarowthu (Drexel University, United States)
"A Novel Interaction Between long non-coding RNA lncTCF7 and SND1 Modulates the gene Regulation Activity of the SWI/SNF Complex"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulatory Modifications in Nucleic Acids and Immune Sensing
Discussion Leader: David Lilley (University of Dundee, United Kingdom)
7:30 pm - 7:50 pm
Peter Beal (University of California, Davis, United States)
"Structure-Guided Optimization of Guide Strands for Directed RNA Editing"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Kate Meyer (Duke University, United States)
"Investigating mRNA Methylation in Single Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jane Jackman (Ohio State University, United States)
"Non-Canoncial roles for RNA Processing Enzymes in tRNA Modification"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Stacy Horner (Duke University, School of Medicine, United States)
"RNA Modifications at the Virus-Host Interface"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Nucleic Acid Processing Machines: New Systems and Biophysics
Discussion Leader: Ailong Ke (Cornell University, United States)
9:00 am - 9:20 am
Michelle Wang (Cornell University, United States)
"DNA Topology and Mechanics of Fundamental Processes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stewart Shuman (Memorial Sloan Kettering Cancer Center, United States)
"tRNA Splicing and Tpt1: The Gifts that keep on Giving"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kathleen Collins (University of California, Berkeley, United States)
"Harnassing Eukaryotic Retroelement Mechanisms for Transgene Supplementation of the Human Genome using RNA-only Delivery"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rui Zhao (University of Colorado Anschutz Medical Campus, United States)
"Understanding 5' Splice Site Recognition"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Stephen P. Bell (Howard Hughes Medical Institute / Massachusetts Institute of Technology, United States)
"Single-Molecule Studies of Replication Origin Licensing"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Amy Fernandez (Johns Hopkins School of Medicine, United States)
"The AAA+ Helicase Loader DnaI is an Iron-Sulfur Cluster Protein"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Hong Wang (North Carolina State University, United States)
"DNA Capture and loop Extrusion Dynamics by Cohesin-NIPBL at the Single-Molecule Level"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Overcoming RNA, DNA, and Nucleotide Damage
Discussion Leader: Tanya Paull (University of Texas at Austin, United States)
7:30 pm - 7:50 pm
Catherine Freudenreich (Tufts University, United States)
"Strategies for Replication through DNA structures"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Puck Knipscheer (Hubrecht Institute, The Netherlands)
"Mechanisms that Resolve DNA G-Quadruplex Structures"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Brandt Eichman (Vanderbilt University, United States)
"Structural Mechanisms of DNA Priming by Polymerase Alpha-Primase"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Stephen West (Francis Crick Institute, United Kingdom)
"Structure and Function of the RAD51B-RAD51C-RAD51D-XRCC2 DNA Repair Complex"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Brooks Crickard (Cornell University, United States)
"Rdh54 Regulates DNA Template Commitment during Homologous Recombination"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Exploiting and Targeting Nucleic Acids in Therapeutics
Discussion Leader: Chang Liu (University of California, Irvine, United States)
9:00 am - 9:20 am
Amanda Hargrove (Duke University, United States)
"Modulating the Conformation and Function of Disease-Relevant RNA with Small Molecules"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Samuel Sternberg (Columbia University, United States)
"Development of CRISPR-Associated Transposases for RNA-guided DNA Integration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Anastasia Khvorova (University of Massachusetts Medical School, United States)
"Delivering Therapeutic Oligonucleotides to the Brain: The Next Frontier for Regulation in the CNS"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Muthiah (Mano) Manoharan (Alnylam Pharmaceuticals, United States)
"Living in the World of Nucleic Acids Therapeutics: Keep Calm and Do Chemistry"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Elizabeth Garner (Caribou Biosciences, Inc., United States)
"Bringing Allogeneic T Cell Therapies to the Clinic using chRDNA Genome Editing Technology"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Orlando Schärer (IBS Center for Genomic Integrity, South Korea)
"TRABI-Seq: Genome-Wide Mapping of Transcription-Coupled Nucleotide Excision Repair and Transcription using the Antitumor Agent Trabectedin"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Hong Li (Florida State University, United States)
"Regulation of Translation by Ribosomal RNA Modifications"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acids in Phase Condensation and Genome and Subcellular Localization
Discussion Leader: Michelle Wang (Cornell University, United States)
7:30 pm - 7:50 pm
Sua Myong (Johns Hopkins University, United States)
"Molecular take on PAR vs. RNA Induced Phase Separation of FUS"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Marina Feric (Penn State University, United States)
"Structure-Function Relationships in Mitochondrial Transcriptional Condensates"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Job Dekker (University of Massachusetts Chan Medical School, United States)
"Determinants of Chromosome Compartmentalization"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Tanya Paull (University of Texas at Austin, United States)
"Mre11-Rad50-Nbs1 and Mechanisms of DNA Double-Strand Break Repair"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure