Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Frontiers in Nucleic Acid Science
7:40 pm - 8:25 pm
"Ribosome as a Trigger of Intra- and Extra-Cellular Stress Responses"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"The role of Replisome-Associated RTF2 in Ribonucleotide Dynamics"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Re-engineering the Central Dogma
9:00 am - 9:20 am
"Experimental Evolution of Chosen Genes near their Mutational Speed Limits"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Genomes by Design: Recoding and Rewriting Life's Genetic Blueprint"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Chemically Mapping Organelles with DNA"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"RNA - A Natural Source of Nanotechnology Building Blocks"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"RNA-Catalyzed Evolution of a Ribozyme"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Structure and Substrate Selection by Eukaryotic Pseudouridine Synthases"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"New methods to Measure and map RNA Modifications"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Comprehensive Analysis of RNA and RNP Higher-Order Architecture by Multi-Site Enhanced DMS Probing"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Flavivirus RNA Structures Modulate Innate Immune Responses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Evolution and Evasion of Antiviral Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Alternative RNA Processing in the Human Immune Response"
8:50 pm - 9:00 pm
Discussion
9:10 pm - 9:20 pm
"Investigating an Intersection of Genome Replication and tRNA Aminoacylation in Human Mitochondria"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:35 pm
"Systematic Evaluation of Cotranscriptional RNA Folding Mechanisms using an RNA-Dependent DNA Partitioning Assay"
9:35 pm - 9:40 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nucleic Acid Processing Machines: Regulation and Structure
9:00 am - 9:20 am
"Structural Basis of DNA Double-Strand Break Repair by NHEJ"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"From Cutting to Chemical Modifications—How Proteins Recognize Substrate RNAs"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Beyond RNA-Guided Nucleases: RNA-Guided Protease Activation in CRISPR-Cas"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The "Other" Side of XPD"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Structural Insights into the Mechanism of DNA Binding and Cleavage by Spo11"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Structural Basis for DNA Proofreading"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structure-Specific roles for PolG2-DNA Complexes in Maintenance and Replication of Mitochondrial DNA"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Novel Interaction Between long non-coding RNA lncTCF7 and SND1 Modulates the gene Regulation Activity of the SWI/SNF Complex"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulatory Modifications in Nucleic Acids and Immune Sensing
7:30 pm - 7:50 pm
"Structure-Guided Optimization of Guide Strands for Directed RNA Editing"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Investigating mRNA Methylation in Single Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Non-Canoncial roles for RNA Processing Enzymes in tRNA Modification"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"RNA Modifications at the Virus-Host Interface"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Nucleic Acid Processing Machines: New Systems and Biophysics
9:00 am - 9:20 am
"DNA Topology and Mechanics of Fundamental Processes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"tRNA Splicing and Tpt1: The Gifts that keep on Giving"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Harnassing Eukaryotic Retroelement Mechanisms for Transgene Supplementation of the Human Genome using RNA-only Delivery"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Understanding 5' Splice Site Recognition"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Single-Molecule Studies of Replication Origin Licensing"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The AAA+ Helicase Loader DnaI is an Iron-Sulfur Cluster Protein"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"DNA Capture and loop Extrusion Dynamics by Cohesin-NIPBL at the Single-Molecule Level"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Overcoming RNA, DNA, and Nucleotide Damage
7:30 pm - 7:50 pm
"Strategies for Replication through DNA structures"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Mechanisms that Resolve DNA G-Quadruplex Structures"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Structural Mechanisms of DNA Priming by Polymerase Alpha-Primase"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Structure and Function of the RAD51B-RAD51C-RAD51D-XRCC2 DNA Repair Complex"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Rdh54 Regulates DNA Template Commitment during Homologous Recombination"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Exploiting and Targeting Nucleic Acids in Therapeutics
9:00 am - 9:20 am
"Modulating the Conformation and Function of Disease-Relevant RNA with Small Molecules"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Development of CRISPR-Associated Transposases for RNA-guided DNA Integration"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Delivering Therapeutic Oligonucleotides to the Brain: The Next Frontier for Regulation in the CNS"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Living in the World of Nucleic Acids Therapeutics: Keep Calm and Do Chemistry"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Bringing Allogeneic T Cell Therapies to the Clinic using chRDNA Genome Editing Technology"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"TRABI-Seq: Genome-Wide Mapping of Transcription-Coupled Nucleotide Excision Repair and Transcription using the Antitumor Agent Trabectedin"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Regulation of Translation by Ribosomal RNA Modifications"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleic Acids in Phase Condensation and Genome and Subcellular Localization
7:30 pm - 7:50 pm
"Molecular take on PAR vs. RNA Induced Phase Separation of FUS"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Structure-Function Relationships in Mitochondrial Transcriptional Condensates"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Determinants of Chromosome Compartmentalization"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Mre11-Rad50-Nbs1 and Mechanisms of DNA Double-Strand Break Repair"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure