Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Mechanistic Insights into RNA and DNA Processes
Discussion Leader: Alexander Johnson (Stanford University, USA)
3:45 pm - 3:55 pm
Niladri Sinha (University of Utah, USA)
"The End Is in Sight - Mechanisms of Termini-Dependent Recognition and Cleavage by Dicer"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Tina Liu (University of California, Berkeley, USA)
"Mechanism of Co-Transcriptional DNA and RNA Targeting by a Type III-A CRISPR-Cas Complex"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Xieyang Guo (Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CERBM, France)
"Taking a Break: How a Transcription Factor Helps RNA Polymerase to Pause During Transcription"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA and RNA Biology and Applications to Human Disease
Discussion Leaders: Bhalchandra Rao (University of Colorado Boulder / Howard Hughes Medical Institute, USA) and Diego Vargas Blanco (Worcester Polytechnic Institute, USA)
7:30 pm - 7:40 pm
Agnes Karasik (Uniformed Services University of the Health Sciences, USA)
"Human Pathogenic tRNA Mutations Influence 5'-End tRNA Processing in the Mitochondria"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Jiyu Wang (University of Rochester, USA)
"Defining Mechanisms that Maintain Reading Frame in Eukaryotic Translation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Andreas Moor (Weizmann Institute of Science, Israel)
"Global mRNA Polarization in the Intestinal Epithelium Regulates Translation Efficiency"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Sneha Rath (Princeton University, USA)
"Innate Immune Endoribonuclease RNase L Balances Between Proliferation Control and Apoptosis Based on dsRNA Load"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Ammar Naqvi (Children's Hospital of Philadelphia, USA)
"Aberrant Splicing in B-Cell Acute Lymphoblastic Leukemia"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Sara Rouhanifard (University of Pennsylvania, USA)
"Fluorescent Amplification of Individual mRNAs in Single Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Maria Loressa Uson (Weill Cornell Graduate School of Medical Sciences, USA)
"The DNA Repair Repertoire of Mycobacterium smegmatis FenA Includes the Incision of DNA 5' Flaps and the Removal of 5' Adenylylated Products of Aborted Nick Ligation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Vedia Yerlici (Princeton University / Columbia University Medical Center, USA)
"The Role of KU Proteins in Genome Maintenance and Programmed Genome Rearrangement in the Ciliate Oxytricha trifallax "
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Specificity and Structure in Nucleic Acid Processes
Discussion Leaders: Yicheng Long (University of Colorado Boulder / Howard Hughes Medical Institute, USA) and Quan Lam (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:10 am
Juan Tosar (Institut Pasteur de Montevideo, Uruguay)
"Extracellular-Enriched tRNA Halves Assemble into Nuclease-Resistant Oligomers with Potent Immunostimulatory Activity"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Nathan Howell (Ohio State University, USA)
"A Family Expands: Characterization of Human TRMT10B, a Multifunctional tRNA Methyltransferase"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Tien-Hao Chen (Ohio State University, USA)
"Substrate Recognition by Arabidopsis Proteinaceous RNase P Isoenzymes: Insights into Catalysis"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Weihan Li (University of California, San Francisco, USA)
"Evolutionary Divergence of IRE1 RNase Specificity Shapes the Unfolded Protein Response"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Chad Torgerson (Yale University, USA)
"High-Throughput Mutational Analysis of the Glycine Riboswitch by Sequencing"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Eric Strobel (Northwestern University, USA)
"Characterization of Cotranscriptional RNA Structure Using SHAPE-Seq"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Indrajit Lahiri (University of California, San Diego, USA)
"How Does Transcription Avoid Roadblocks?"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Rebecca Keener (Johns Hopkins School of Medicine, USA)
"Tel1(ATM) and Mec1(ATR) Domain Swaps in S. cerevisiae to Distinguish Telomere Length and DNA Damage Functions"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development and Mentorship
Discussion Leaders: Tina Liu (University of California, Berkeley, USA) and Simona Graziano (Saint Louis University School of Medicine, USA)
1:30 pm - 1:50 pm
Karen Cone (National Science Foundation, USA)
"How to Get Funded by the National Science Foundation"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:20 pm
Jane Jackman (Ohio State University, USA)
"Now What? Taking the Next Steps Towards Your Career in Science"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
