Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Nucleic Acid Technologies
Discussion Leader: George Ghanim (University of California, Berkeley, USA)
3:45 pm - 3:55 pm
Lazaros Melidis (University of Birmingham, United Kingdom)
"Targeting Nucleic Acid Structures with Supramolecular Cylinders"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Joanna Miszkiewicz (University of Warsaw, Poland)
"Designed RNA Enzyme as a Potential Antibacterial"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
David Calabrese (National Cancer Institute, NIH, USA)
"Chemical and Structural Studies Provide a Mechanistic Basis for Selective Recognition of the MYC G-Quadruplex"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organization and Regulation of DNA and RNA Biology
Discussion Leader: Nilisha Pokhrel (Marquette University, USA)
7:30 pm - 7:40 pm
Sarah Northall (University of Bristol, United Kingdom)
"CtIP DNA Binding Deficiencies Contribute to the Molecular Basis of Seckel 2 and Jawad Syndromes"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Catherine Bradley (Baylor College of Medicine, USA)
"Conflicts Between a DNA End-Binding Protein and Transcription at Double-Strand Breaks"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Sadeem Ahmad (Boston Children's Hospital / Harvard Medical School, USA)
"Role of Alu Duplex RNAs in MDA5-Mediated Interferonopathies"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Cristhian Cadena (Program in Virology, Harvard Medical School, USA)
"Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Sara Martin (University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, USA)
"Translesion DNA Polymerase Zeta Suppresses an Innate Immune Response"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Samantha Dodbele (The Ohio State University, USA)
"An Orphan 3'-5' Polymerase Implicated in Noncoding RNA Processing"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Thareendra De Zoysa (University of Rochester Medical Center, USA)
"Similarities and Differences in tRNA Quality Control Decay Pathways in Evolutionarily Distant Yeast Species"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Jacob Gordon (National Institute of Environmental Health Sciences, National Institutes of Health, USA)
"Regulation of the Essential Human Ribosomal RNA Processing Machinery, Las1L-Nol9"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Structures and Mechanisms of Nucleic Acid Biology
Discussion Leader: Thi Hoang Duong Nguyen (University of California, Berkeley, USA)
9:00 am - 9:10 am
Basil Greber (University of California, Berkeley, USA)
"The Complete Structure of the Human TFIIH Core Complex"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Eric Strobel (Northwestern University, USA)
"A Mechanism for Ligand Gated Strand Displacement in ZTP Riboswitch Transcription Regulation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Oyindamola Adefisayo (Memorial Sloan Kettering Cancer Center, USA)
"The Role of Phosphorylation in DNA Damage Response in Mycobacterium"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Nimit Jain (Stanford University, USA)
"Diversity, Molecular Mechanisms and Origins of RNAs Replicated by a Transcription Polymerase"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Ananthanarayanan Kumar (MRC Laboratory of Molecular Biology, United Kingdom)
"Mechanistic Insights into Eukaryotic mRNA 3' End Processing"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Monica Pillon (National Institute of Environmental Health Sciences, NIH, USA)
"Active Site Coordination Within a Multienzyme Pre-rRNA Processing Complex"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Andrew Savinov (University of Washington, USA)
"A Fragile Folding Interaction Controls Catalysis in the GlmS Ribozyme Riboswitch"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Mohamed Nasef (University of Alabama, USA)
"Regulation of Cyclic Oligoadenylate Synthesis by the S. epidermidis Cas10-Csm Complex"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Education, Career Development and Mentorship
The mentorship session will include a keynote talk on careers in biology and an NIH/NSF career panel.
Discussion Leader: Ankan Banerjee (Memorial Sloan Kettering Cancer Center, USA)
1:30 pm - 1:50 pm
Lisa Postow (National Heart, Lung, and Blood Institute, NIH, USA)
"Careers in Biology"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:30 pm
Panel Discussion
NIH/NSF Careers
Manju Hingorani (National Science Foundation / Wesleyan University, USA)
Lisa Postow (National Heart, Lung, and Blood Institute, NIH, USA)
Keren Witkin (National Cancer Institute, NIH, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
