Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Frontiers of Nucleic Acid Therapaeutics
Discussion Leader: Susan Liao (New York University, United States)
3:45 pm - 3:55 pm
Tianshuo Liu (Yale University, United States)
"Development of Novel Antifungals Targeting Tertiary Structured Riboregulatory Elements"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Elizabeth Tidwell (University of Michigan, United States)
"High Throughput Screening of Small Molecule Binding Partners for the FMN Riboswitch by a Multidisciplinary Approach"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Sicong Ma (University of Michigan, United States)
"Structure of pre-miR-31 Reveals an Active role in Dicer Processing"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Technological Advancements in Understanding Nucleic Acid Biology
Discussion Leader: Rebecca Roddan (University of Oxford, United Kingdom)
7:30 pm - 7:40 pm
Akanksha Manghrani (Duke University, United States)
"Probing Hoogsteen base-pairs in vitro and in cells"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Luiz Passalacqua (NHLBI - NIH, United States)
"Structural Basis for Fluorophore Activation by a DNA Mimic of Green Fluorescent Protein"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Jesse Pyle (New England Biolabs, United States)
"Novel Cytosine Hypermodifications by Diverse Bacteriophage Glycosyltransferases"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Pulak Ghosh (Indian Institute of Science Education and Research (IISER), Pune, India)
"Probing the Chemical Space Tolerance and Processivity of DNA Polymerases in real time and 3D Using Responsive Fluorescent Nucleotide Analogs"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
David Qiu (UNC Chapel Hill, United States)
"Discovering RNA Tertiary Structures Using Chemical Probing"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Susan Liao (New York University, United States)
"Interpretable Machine Learning to Decipher Splicing Regulatory Logic"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Sarah Strassler (Emory University, United States)
"tRNA m1G9 Modification Depends on Substrate-Specific RNA Conformational Changes Induced by the Methyltransferase Trm10"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Seth Veenbaas (UNC - Chapel Hill, United States)
"Ligand-binding pockets in RNA and where to find them"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Mechanisms of Gene Expression Regulation
Discussion Leader: Suparno Nandi (Emory University, United States)
9:00 am - 9:10 am
Ling Xu (Yale University, United States)
"Group II Intron Splicing Mechanisms - Ribozymes and Retrotransposons"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Rebecca Roddan (University of Oxford, United Kingdom)
"The Molecular Basis of DNA Interstrand Crosslink Resection During Transcription-Coupled Repair"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Carmen Grandi ( Radboud University, The Netherlands)
"Decoupled Degradation and Translation Enables Noise-Modulation by Poly(A)-Tails"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
David Beier (University of Michigan, United States)
"Turning Up the Heat: The Dynamic Role of the prfA RNA Thermosensor in Translation Regulation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Natalie Popielski (State University of New York at Buffalo, United States)
"Evidence Supporting a Distinct Model for Activity of Mutagenic DNA Polymerase ImuC in Pseudomonas Aeruginosa"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Urmimala Basu (Harvard Medical School, United States)
"Characterizing the role of the Yeast cap Methyltransferase Abd1 in Transcription Regulation"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Praneeth Bommisetti (Graduate Student, United States)
"Insights into mechanism of installation of 5-carboxymethylaminomethyl uridine hypermodification by tRNA modifying enzymes MnmE and MnmG"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Syed Usman Enam (Stanford University School of Medicine, United States)
"Weird Bases in Weird Places: A Molecular Metagenomic Screen Reveals Genomes with Non-Canonical Bases"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Scientific Journey: Graduate School and Beyond
Discussion Leader: Urmimala Basu (Harvard Medical School, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Panel Discussion
Scientific Journey:Graduate School and Beyond
Yamuna Krishnan (University of Chicago, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
