Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Frontiers of Nucleic Acid Therapaeutics
3:45 pm - 3:55 pm
"Development of Novel Antifungals Targeting Tertiary Structured Riboregulatory Elements"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
"High Throughput Screening of Small Molecule Binding Partners for the FMN Riboswitch by a Multidisciplinary Approach"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
"Structure of pre-miR-31 Reveals an Active role in Dicer Processing"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Technological Advancements in Understanding Nucleic Acid Biology
7:30 pm - 7:40 pm
"Probing Hoogsteen base-pairs in vitro and in cells"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Structural Basis for Fluorophore Activation by a DNA Mimic of Green Fluorescent Protein"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Novel Cytosine Hypermodifications by Diverse Bacteriophage Glycosyltransferases"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Probing the Chemical Space Tolerance and Processivity of DNA Polymerases in real time and 3D Using Responsive Fluorescent Nucleotide Analogs"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Discovering RNA Tertiary Structures Using Chemical Probing"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Interpretable Machine Learning to Decipher Splicing Regulatory Logic"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"tRNA m1G9 Modification Depends on Substrate-Specific RNA Conformational Changes Induced by the Methyltransferase Trm10"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Ligand-binding pockets in RNA and where to find them"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Mechanisms of Gene Expression Regulation
9:00 am - 9:10 am
"Group II Intron Splicing Mechanisms - Ribozymes and Retrotransposons"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"The Molecular Basis of DNA Interstrand Crosslink Resection During Transcription-Coupled Repair"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Decoupled Degradation and Translation Enables Noise-Modulation by Poly(A)-Tails"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Turning Up the Heat: The Dynamic Role of the prfA RNA Thermosensor in Translation Regulation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Evidence Supporting a Distinct Model for Activity of Mutagenic DNA Polymerase ImuC in Pseudomonas Aeruginosa"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Characterizing the role of the Yeast cap Methyltransferase Abd1 in Transcription Regulation"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Insights into mechanism of installation of 5-carboxymethylaminomethyl uridine hypermodification by tRNA modifying enzymes MnmE and MnmG"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Weird Bases in Weird Places: A Molecular Metagenomic Screen Reveals Genomes with Non-Canonical Bases"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Scientific Journey: Graduate School and Beyond
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Panel Discussion
Scientific Journey:Graduate School and Beyond
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
