Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Global Impacts of Nucleic Acid Medicine
7:40 pm - 8:05 pm
"Advancing the Health of Human Beings around the World"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"RNAi Therapeutics, The Next Chapter"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Harnessing the power of CRISPR for Therapeutic Applications"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structural Chemistry of Nucleic Acids
9:00 am - 9:20 am
"Structures and Mechanisms of Argonaute Proteins"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structure Derived Applications of Xeno Nucleic Acids in RNAi Therapeutics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:25 am
Coffee Break
10:25 am - 10:50 am
"Mechanisms of Interactions Between Therapeutic Oligonucleotides and Proteins"
10:50 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Creation of a Nucleic Acids' Toolbox for the Treatment and Etiology of Disease"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Prediction of RNA Duplex Stability in Diverse in Vitro and Cellular-Like Crowding Conditions"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Diversity of Tandem Repeats"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Development of Novel Exosome-Hijacking Drug Delivery System for Targeting Exosomal-MicroRNAs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nucleoside and Nucleotide Natural Products
7:30 pm - 7:55 pm
"Chemical Logic of MraY Inhibition by Antibacterial Nucleoside Natural Products"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Medicinal Chemistry with Analogues of Muraymycin Nucleoside Antibiotics"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Enzymatic Transformation of Nucleosides and Nucleotides into Antibiotics"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Drug Discovery and E. coli HeptosyltransferaseI - How basic science research might change our understanding of an antibiotic mechanism of action"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Challenges and Opportunities for Nucleic Acid Therapeutics
9:00 am - 9:20 am
"Thiomorpholino Oligonucleotides (TMOs): A Robust Next Generation Platform for RNA Targeting Therapies"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Design and Synthesis of mRNA by Chemical Methods"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"SNCA-targeting siRNAs Prevent Disease Progression in a Synucleinopathy Mouse Model"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Extended Nucleic Acid (exNA): A Platform Technology Development for Enhancing siRNA Potency in Vivo"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Expanding the Medicinal Chemistry Scope of Acetylation to Synthetic mRNA"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Aminooxy Click Chemistry (AOCC) on Support and in Solution: Expanding the Scope of Bioconjugation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Towards Lipophilic Prodrugs of Antisense Oligonucleotides"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Synthesis of Oligonucleotide Conjugates via Diselenide-Selenoester Ligation Deselenization / Alkylation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Oligonucleotide Therapeutics
7:30 pm - 7:50 pm
"A Novel RNA-Based Approach to Treat Genetic Diseases via Upregulation of Protein Expression"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Spacer Fidelity Assessment of Guide RNAs"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Improving Safety and Specificity of RNAi Therapeutics"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"Advancing Oligonucleotide Therapeutics with Chimeric Phosphoryl Guanidine-Containing Backbone"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Recent Advances in Antibody Oligonucleotide Conjugates for the Treatment of Muscular Dystrophies"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Small Molecules: Chemistry and Applications
9:00 am - 9:25 am
"7-Deazaadenosine Analogs are Highly Promising Lead Compounds against Protozoan Pathogens"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Purine Nucleoside Phosphorylase Inhibitors for the Treatment of T-Cell Leukemias"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Nucleoside Analogues Beyond Antivirals and Anticancer: Exploring Their Potential Against Schistosoma"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Membrane-permeAble, STabilized biorEversible-pRotected Adenine Nucleotide second Messengers - MASTER-NAADP and -AMP derivatives for Chemical Biology"
11:35 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"Chemical Synthesis of 4'-Modified Pyrimidine Nucleoside Analogues"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Metalated Furopyrimidine Nucleosides: 5-(µ2)Alkyne Dicobalt Hexacarbonyl Hybrids"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutics for Coronaviruses
7:30 pm - 7:55 pm
"The Metabolic Activation Pathway and Mechanism of Action of Bemnifosbuvir Against the SARS-CoV-2 Replicase"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Can Biochemical Data Predict Antiviral Activities of Nucleotide Analogue Inhibitors of Viral Polymerases?"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Discovery and Development of Novel Nucleoside Analogs for SARS-CoV-2 Infections"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Polypurine Reverse Hoogsteen (PPRH) hairpins as a tool for detecting and inhibiting Proliferation of SARS-CoV-2"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Chemical Biology and Nucleic Acid-Based Diagnostics
9:00 am - 9:25 am
"Allosteric Aptamers as Molecular Switches for Target Sensing"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Development of RNA-Based Tools for Diagnostic and Therapy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Optical Control of mRNA Translation"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Using Aptamers to Detect Small Molecules"
11:40 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Differential Regulation of SIRT5 Activity by Nicotinamide Riboside"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Synthesis and Characterization of DNA-Modified Janus Dendrimers for Targeted Delivery Applications"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA-Targeting and Epitranscriptomes
7:30 pm - 7:50 pm
"Enabling Technologies for Revealing Druggable Paths in RNA Biology"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Engineering of Riboswitch Aptamers for Covalent RNA Modification"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Development of Nucleoside Derivatives to Improve Safety of Gapmer Antisense Oligonucleotides"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Harnessing Endogenous ADAR for Oligo-Directed RNA Editing"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Function of Chemical Modifications in Bacterial tRNAs"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure