Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Small Molecules and Oligomers for the Study, Diagnosis and Treatment of Disease
3:45 pm - 4:15 pm
"Polymer Nanomaterials as Delivery Systems for Oligonucleotides"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Improved Molecular Recognition Using Small Molecules and Oligomers
7:30 pm - 7:40 pm
"Synthetic Solvatochromic Nucleosides as Sensors for Glycosyltransferases"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Investigating RNA Structural Motifs Using Small Molecule-Based Pattern Recognition"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"A Pronucleotide Probe for Functional Analysis of Protein AMPylation During Neuronal Differentiation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Bioorthogonal Labelling of Modified mRNA with Increased Translational Efficiency in Living Cells"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Water Purification to Remove Small-Molecule Contaminants Using Aptamer-Functionalized Membranes"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Assigning Positional Stereochemistry for Stereopure Oligonucleotides"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"When Biological Machines Encounter Reversible Crosslinks in Duplex DNA"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Synthetic Modifications for Optimized Nucleic Acid Therapeutics
9:00 am - 9:10 am
"Syntheses and RNAi Activity of Amide-Modified siRNAs"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Synthesis and Incorporation into RNA of NAD Analogues: New Tools to Study Decapping Enzymes"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Investigations into the Mechanism of Action of Flexible Nucleoside Analogues Against Flaviviruses"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Nucleobase Modifications to Improve Triple Helical Recognition of dsRNA and Cellular Delivery of PNA"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Improving Efficiency of HIV-1 FSS RNA-Targeting Compounds"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Development of NPP1 Inhibitors as Potential Drugs for the Treatment of Osteoarthritis/CPPD Disease"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Using the Chloroalkane Cell Penetration Assay (CAPA) for the Optimization of RNA Therapeutics"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: The Journey from Academia to Industry and Back Again
The 2019 GRS on NNO is unique because of the participation by the panel members who are established leaders in academia and the industry. The first half of the mentorship component will commence with a brief description of the professional journey traversed by each panel member and the second half will conclude with an open question and answer session where GRS participants can take full advantage of the immense cross-disciplinary expertise available on the floor.
1:30 pm - 2:30 pm
Panel Discussion
Navigating Career in Nucleic Acid Sciences
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes