Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Welcome to Chemical Biology and Clinical Applications of Nucleosides, Nucleotides and Oligomers
Discussion Leader: Otto Linden (University of Strathclyde, United Kingdom)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Wendy Gilbert (Yale University, United States)
"Illuminating 1,000-Fold Regulation of Translation to Engineer mRNA Medicines"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structure and Function of Natural and Synthetic Macromolecules
Discussion Leader: Manusha Gamage (Johns Hopkins University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
Kornelia Skowron (Washington University in Saint Louis, United States)
"Development of Photocaged Amino Acid Sidechain Peptide Nucleic Acid (PNA) Monomers to Enable Rapid Modulation of Assembly State"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Stefan Crielaard (Radboud University, The Netherlands)
"Affinity-Based Profiling of the Flavin Mononucleotide Riboswitch"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Colin Martin (Carnegie Mellon University, United States)
"Monitoring Cellular Delivery of PNA-Peptide Conjugates"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Prakash Kharel (Brigham and Women's Hospital/ Harvard Medical School, United States)
"tRNA Fragment Analogs as a Potential Therapeutic for Cancers and ALS/FTD"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Alissa Drees (University of Hamburg, Germany)
"Automated High-Throughput Selection of Aptamers Using a Modified Optical Next-Generation Sequencer"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Joseph Broomfield (Imperial College London, United Kingdom)
"TMPRSS2-ERG and AR Circulating mRNA Detection for Prostate Cancer Prognosis Using a Lab-on-Chip Device"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Tomasz Spiewla (University of Warsaw, Faculty of Physics / Explorna Therapeutics, Poland)
"Determining the Affinity of Various Capped RNAs for the IFIT1 Protein Using Microscale Thermophoresis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Chemical Biology and Engineering of Small Molecules
Discussion Leader: Tariq Al-Jarah (University of Colorado Denver, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:15 am
Joy Thames (University of Maryland, Baltimore County, United States)
"Modified Flex-Acyclovir Analogues: A Journey to Discovering Broad-Spectrum Antiviral Therapeutics"
9:15 am - 9:20 am
Discussion
9:20 am - 9:30 am
Maria Lafuente (University of Maryland Baltimore County, United States)
"Design and Synthesis of Novel D-Ribose Flex-Nucleoside Analogues and Evaluation as Antiviral Therapeutics Agents"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Andrea Taladriz-Sender (University of Strathclyde, United Kingdom)
"Establishing a Chemical Biological Toolbox to Understand the Mechanisms of Splice-Switching Small Molecules"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Pulak Ghosh (Indian Institute of Science Education and Research (IISER), Pune, India)
"Probing the Chemical Space Tolerance and Processivity of DNA Polymerases in Real Time and 3D Using Responsive Fluorescent Nucleotide Analogs"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Ya Ying Zheng (SUNY Albany, United States)
"Inosine and Reverse Transcriptases"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Ravina Moirangthem (Johns Hopkins University, United States)
"Exploring the Kinetics of Quinone Methide (QM) Transfer Along DNA with 1,8-Naphthalimide Intercalating Agent"
10:30 am - 10:35 am
Discussion
10:35 am - 10:45 am
Matthew Egleston (The Johns Hopkins University School of Medicine, United States)
"Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Insights into the State of Careers in Academia and Industry
Discussion Leader: Giuliano Kullik (UMBC, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Panel Discussion
Navigating Careers in Academia and Industry
Michelle Lynn Hall (Eli Lilly, United States)
Amanda Bryant-Friedrich (Wayne State University, United States)
Wendy Gilbert (Yale University, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
