Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Welcome to Chemical Biology and Clinical Applications of Nucleosides, Nucleotides and Oligomers
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
"Illuminating 1,000-Fold Regulation of Translation to Engineer mRNA Medicines"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structure and Function of Natural and Synthetic Macromolecules
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
"Development of Photocaged Amino Acid Sidechain Peptide Nucleic Acid (PNA) Monomers to Enable Rapid Modulation of Assembly State"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
"Affinity-Based Profiling of the Flavin Mononucleotide Riboswitch"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Monitoring Cellular Delivery of PNA-Peptide Conjugates"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"tRNA Fragment Analogs as a Potential Therapeutic for Cancers and ALS/FTD"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Automated High-Throughput Selection of Aptamers Using a Modified Optical Next-Generation Sequencer"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"TMPRSS2-ERG and AR Circulating mRNA Detection for Prostate Cancer Prognosis Using a Lab-on-Chip Device"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Determining the Affinity of Various Capped RNAs for the IFIT1 Protein Using Microscale Thermophoresis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Chemical Biology and Engineering of Small Molecules
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:15 am
"Modified Flex-Acyclovir Analogues: A Journey to Discovering Broad-Spectrum Antiviral Therapeutics"
9:15 am - 9:20 am
Discussion
9:20 am - 9:30 am
"Design and Synthesis of Novel D-Ribose Flex-Nucleoside Analogues and Evaluation as Antiviral Therapeutics Agents"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Establishing a Chemical Biological Toolbox to Understand the Mechanisms of Splice-Switching Small Molecules"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Probing the Chemical Space Tolerance and Processivity of DNA Polymerases in Real Time and 3D Using Responsive Fluorescent Nucleotide Analogs"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Inosine and Reverse Transcriptases"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Exploring the Kinetics of Quinone Methide (QM) Transfer Along DNA with 1,8-Naphthalimide Intercalating Agent"
10:30 am - 10:35 am
Discussion
10:35 am - 10:45 am
"Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Insights into the State of Careers in Academia and Industry
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Panel Discussion
Navigating Careers in Academia and Industry
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
