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6:00 p.m. Dinner
7:15 Welcome & Introductory Remarks
Session 1
Bill Berkowitz, Queens’ College, New York City - Discussion Leader
7:30 p.m. Nanette M Wachter-Jurcsak, Hofstra University “Preparation and Properties of N,N-Dimethylamino Substituted Flavanoids”
8:15 Discussion
8:30 Break
8:45 Leland O Weigel, Eli Lilly & Company “New Synthesis Methods for Non-Racemic Benzo[f]quinalinones: Clinically Important 5-d-Reductase Inhibitors “
9:20 Discussion
6:30 a.m. Breakfast
Session 2
Chris Schmid, Eli Lilly & Company - Discussion Leader
8:15 a.m. Announcements
8:30 Alcide Perboni, Glaxo Wellcome S.p.A. “Process Research & Scale-up of the Synthesis of the 4- Formamidino Substituted Trinem, GV129606X”
9:15 Discussion
9:30 Goege Wu, Schering Plough “A Novel One-Step Diastereo- and Enantioselective Formation of trans-Azetidinones and its Application to the Total Synthesis of Cholesterol Absorption Inhibitors”
10:05 Discussion
10:15 Break
Session 3
Greg Reid, Advanced American Organics - Discussion Leader
10:30 a.m. Kevin Babiak, G.D. Searle “Optimization of a Process to Make an Unusual ?-Aminobutyrolactam, A Key Intermediate for Orbofiban”
11:05 Discussion
11:15 Keith DeVries, Pfizer, Inc.
“The Preparation of ß-Substituted Amines from Regioisomeric Mixtures of Epoxide Opening Products via a Common Aziridinium Ion Intermediate: Application to a Drug Candidate”
11:50 Discussion
12:00 Lunch
4:00 - 6:00 Poster Session 1
6:00 Dinner
Session 4
Cindy Maryanoff, R. W. Johnson Pharm. Research - Discussion Leader
7:15 p.m. Tim Watson, Hoechst Marion Roussel
“Chemical Development of MDL 103371: an N-methyl-D- aspartate (NMDA)-type Glycine Receptor Antagonist for the Treatment of Stroke”
7:50 Discussion
8:00 Ed Delaney, Bristol Myers Squibb “Reassessment of N-Trifluoroacetylation as a Protection Strategy in Amino Acid Coupling Reactions”
8:35 Discussion
8:45 Break
9:00 Mukund Sibi, North Dakota State University “The Role of Achiral Templates in Enantioselective Transformations”
9:45 Discussion
6:30 a.m. Breakfast
Session 5
Steve King, Abbott Laboratories - Discussion Leader
8:15 a.m. Photo Session - BE PROMPT
8:45 Announcements
9:00 Amir Hoveyda, Boston College “Recent Advances in Asymmetric Catalysis”
9:45 Discussion
10:00 Joe Armstrong, Merck & Co., Inc. “An Efficient Asymmetric Synthesis of a Growth Hormone Secretagogue”
10:35 Discussion
10:45 Break
Session 6
Gerald Hammond, University of Massachusetts - Discussion Leader
11:00 a.m. Mike O’Brien, Rhone-Poulenc Rorer
“Novel Approaches to an Industrial Process for the Preparation of Adenosine Agonist with Five Chiral Centers”
11:35 Discussion
11:45 Bruce Maryanoff, R.W. Johnson Pharm.Research “Control of Stereocenters Separated by Four or More Bonds in Strictly Acyclic Substrates”
12:20 Discussion
12:30 Lunch
1:30 3rd Annual OR&P Golf “Classic”
Session 7
Mike Lipton, Pharmacia & UpJohn - Discussion Leader
7:15 p.m. Xuma Zhang, Penn State University “Developing a Chiral Toolbox for Asymmetric Catalytic Reactions”
8:00 Discussion
8:15 Break
8:30 Nick Magnus, Dupont Pharmaceuticals “Synthesis of Cyclic Urea HIV Drug Candidates”
9:05 Discussion
9:15 Rob Leanna, Abbott Laboratories “Synthesis of a Novel Anti-Infective Agent”
9:50 Discussion
10:00 Business Meeting and Nominations
| Wednesday - July 14, 1999 |
6:30 a.m. Breakfast
Session 8
Jim Behling, G.D. Searle- Discussion Leader
8:15 a.m. Announcements
8:30 Vic Snieckus, Queen’s University “From Flatland to Prochiral Metalation”
9:15 Discussion
9:30 Jack Brown, Roche Colorado “From Laboratory to 12,000 liters. A Chemist’s Perspective”
10:05 Discussion
10:15 Break and Election of Chair for 2001
Session 9
Shon Pulley, University of Missouri-Columbia - Discussion Leader
10:30 Neil Baine, SmithKline Beecham “The Evolution of a Cost Effective Synthesis-from Route Discovery to Manufacturing”
11:05 Discussion
11:15 a.m. Larry Truesdale, Alanex Corporation “Process Chemistry before Discovery Chemistry?”
11:50 Discussion
12:00 Lunch
4:00 - 6:00 Poster Session 2
6:00 Dinner
Session 10
Don Hou, Schering Plough Research - Discussion Leader
7:10 p.m. Election Results
7:15 Wilfried Hoffmann, Warner Lambert “Use of RC1/ReactIR in Chemical Development”
7:50 Discussion
8:00 Peter Wuts, Pharmacia & Upjohn “Synthesis of PNU-95666E”
8:35 Discussion
8:45 Break
9:00 Mikiko Sodeoka, Sagami Chemical Research “Catalytic Enantioselective Reactions via Palladium Enolates”
9:45 Discussion
6:30 a.m. Breakfast
Session 11
Rich Pariza, CP Consulting, Inc. - Discussion Leader
8:15 a.m. Announcements
8:30 Günther Helmchen, University of Heidelberg “Recent Progress in Asymmetric Allylic Substitutions”
9:15 Discussion
9:30 Nizar Haddad, Boehringer Ingelheim Pharmaceuticals “New Synthetic Applications of the Photocycloadditions of Cyclic Enomes to Alkeness”
10:05 Discussion
10:15 Break
Session 12
Susan Ensel, Hood College
10:30 a.m. Dave Mootoo, Hunter College “A Convergent, DeNova Approach to the Synthesis of Complex Glycomimetics”
11:05 Discussion
11:15 Randy Halcomb, University of Colorado “Application of Novel Annulation Reactions to the Synthesis of Natural Products”
11:50 Discussion
12:00 Lunch
2:00 Annual Academic/Industrial Softball Game
4:00 - 6:00 Chair’s Reception - Wine Tasting
6:00 Dinner
Session 13
Michael Harmata - Discussion Leader
7:30 p.m. Michael Behe, Lehigh University “The Challenge to Darwinian Evolution”
8:30 Discussion
9:00 Closing Remarks
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