| Sunday July 22, 2001 |
| 6:00 PM | Dinner |
| 7:20 | Welcome and Introductory Remarks |
| Session 1 - Organic Transformations |
| Douglas Livingston, Discussion Leader |
| 7:30 | Anthony G. M. Barrett (Imperial College, London)
"An Overview of Catalysis in Synthesis from Simple Arenes to Antibiotics." |
| 8:20 | Discussion |
| 8:30 | Lisa M. Reeder (Pharmacia, Kalamazoo)
"Process Chemistry Development of (-)-OSU-6162" |
| 8:50 | Discussion |
| 9:00 | J. Gregory Reid (Bristol-Myers Squibb/Albany Molecular)
"Process Development for Lobucavir" |
| 9:30 | Discussion |
| Monday, July 23, 2001 |
| 7:30 AM | Breakfast |
| 8:30 AM | Photo Session |
| Session 2 - Pharmaceutical Process Chemistry |
| Terry Rathman, Discussion Leader |
| 9:15 | Jos Brands (Merck)
"The Power of Crystallization Induced Asymmetric Transformations in Efficient Syntheses of NK-1 Receptor Antagonist MK-0869" |
| 10:00 | Discussion |
| 10:10 | Break |
| 10:30 | Don Hou (Rhodia ChiRex, Inc.)
"Jacobsen Hydrolytic Kinetic Resolution: The Styrene Oxide Story" |
| 11:00 | Discussion |
| 11:10 | Michel Couturier (Pfizer, Groton)
"Practical Large-Scale Synthesis of 3,4-Isopropylidenedioxypyrrolidine Hydrotosylate: Atom Economical Self-hydrogenolysis of a Crystalline Borane-Benzylamine Adduct" |
| 11:40 | Discussion |
| 11:50 | Judith Cohen (R. W. Johnson)
"An Efficient Procedure for the Enantioselective Synthesis of b-Aryl-b-Amino Esters" |
| 12:20 | Discussion |
| 12:30 | Lunch |
| 4:00 - 6:00 | Poster Session 1 |
| 6:00 | Dinner |
| Session 3 - Organometallics in Synthesis |
| Ioannis Houpis, Discussion Leader |
| 7:30 | David B. Collum (Cornell Univeristy)
"Investigations of Organolithium Reaction Mechanisms: Learning How to Manipulate Reactivity and Selectivity" |
| 8:20 | Discussion |
| 8:30 | John A. Soderquist (University of Puerto Rico - Rios Piedras)
"Asymmetric Organoborane Conversions with the Remarkable 10-Substituted-9-Borabicyclo[3.3.2]decanes" |
| 9:20 | Discussion |
| Tuesday, July 24, 2001 |
| 7:30 AM | Breakfast |
| 8:45 | Announcements |
| Session 4 - Synthetic Methodology |
| Vladimir Gevorgyan, Discussion Leader |
| 9:00 | Tarek Sammakia (University of Colorado)
"Application of the Halogen Dance Reaction to the Synthesis of Caerulomycin C and WS75624 B" |
| 9:30 | Discussion |
| 9:40 | Kay M. Brummond (West Virginia University)
"An Allenic Pauson-Khand Cycloaddition and Other Cyclization Strategies to Prepare Biologically Relevant Compounds" |
| 10:10 | Discussion |
| 10:20 | Break |
| Session 5 - Chiral Scaffolding |
| P. Andrew Evans, Discussion Leader |
| 10:30 | Albert I. Meyers (Colorado State University)
"Chiral Bicyclic Lactams: Scaffolds for the Asymmetric Syntheses of Carbocycles and Heterocycles" |
| 11:20 | Discussion |
| 11:30 | Russell J. Linderman (North Carolina State University/Pharmacia, Skokie) |
| 12:00 | Discussion |
| 12:10 | Yian Shi (Colorado State University)
"Asymmetric Epoxidation of Olefins via Chiral Dioxiranes" |
| 12:30 | Lunch |
| 1:30-4:30 | 6th Annual OR&P "Golf" Classic |
| 6:00 | Dinner |
| Session 6 - Ionic Systems |
| William F. Bailey, Discussion Leader |
| 7:30 | Shu Kobayashi (University of Tokyo)
"Efficient Achiral and Chiral Catalysts in Aqueous and Organic Solvents" |
| 8:10 | Discussion |
| 8:20 | Paul Grieco (Montana State University)
"The Use of Oxabicyclo[2.2.1] and [3.2.1]alkenes in Organic Synthesis" |
| 9:00 | Discussion |
| 9:10 | Robert Engel (Queens College)
"New NAILs and LIPs for Organic Reaction Media" |
| 9:30 | Business Meeting |
| Wednesday, July 25, 2001 |
| 7:30 AM | Breakfast |
| 8:45 | Announcements |
| Session 7 - Pharmaceutical Process Chemistry |
| Steven King, Discussion Leader |
| 9:00 | Anthony Haight (Abbott)
"Synthesis of Fiduxosin Hydrochloride" |
| 9:30 | Discussion |
| 9:40 | Richard A. Berglund (Eli Lilly and Company)
"Identification and Development of a Production Process for LY333328, A Semisynthetic Glycopeptide Antibiotic." |
| 10:10 | Discussion |
| 10:20 | Break and election of Chair for 2002 |
| Session 8 - Asymmetric Synthesis |
| Timothy Watson, Discussion Leader |
| 10:35 | Erick Carreira (ETH Zurich)
"The Development and Study of Practical Catalytic Methods for Enantioselective Carbonyl Addition Reactions" |
| 11:25 | Discussion |
| 11:35 | Steven P. Nolan (University of New Orleans)
"Nucleophilic Carbenes as Ligands in Homogeneous Catalysis" |
| 12:05 | Discussion |
| 12:30 | Lunch |
| 4:00 - 6:00 | Poster Session 2 |
| 6:00 | Dinner |
| Session 9 - Synthetic Methodology |
| Richard Pariza, Discussion Leader |
| 7:30 | Steven M. Weinreb (Pennsylvania State University)
"Methodology for Synthesis of Nitrogen Heterocycles" |
| 8:15 | Discussion |
| 8:20 | Gregory R. Cook (North Dakota State University)
"Dynamic Diastereomers. Unusual Selectivity in the Pd-Catalyzed Allylic Substitution" |
| 8:40 | Discussion |
| 8:50 | Tomas Hudlicky (University of Florida)
"Toluene dioxygenase-mediated asymmetric synthesis. An update on recent approaches to morphine and pancratistatin" |
| 9:35 | Discussion |
| Thursday, July 26, 2001 |
| 7:30 AM | Breakfast |
| 8:45 | Announcements |
| Session 10 - Pharmaceutical Process Chemistry |
| Leland Weigel, Discussion Leader |
| 9:00 | Thomas Nanninga (Pfizer, Holland)
"The Synthesis of the Potent ACAT inhibitor PD 140296 and the Active Enantiomer" |
| 9:30 | Discussion |
| 9:40 | Mukund Chorgade (Chorgade Enterprises)
"Optimized Processes for Selected Molecules of Therapeutic Interest" |
| 10:00 | Discussion |
| 10:10 | Break and results of Chair for 2002 election |
| Session 11 - Asymmetric Catalysis |
| Matthew Sigman, Discussion Leader |
| 10:25 | Rodney Parsons (DuPont Pharmaceuticals Company)
"The Development of Commercially Viable Processes for HIV-1 NNRTI Drug Candidates" |
| 10:45 | Discussion |
| 11:00 | Andrei Yudin (University of Toronto)
"The Role of Carbon-Fluorine Bond in Asymmetric Catalysis" |
| 11:20 | Discussion |
| 11:35 | James L. Leighton (Columbia University)
"Strained Silacycles in Organic Synthesis" |
| 12:05 | Discussion |
| 12:30 | Lunch |
| 2:00-4:00 | Annual Academic/Industrial Softball Game |
| 4:00-6:00 | Chair's Reception - Wine Tasting |
| 6:00 | Dinner |
| Session 12 |
| Mukund Sibi, Discussion Leader |
| 7:30 | Dr. Henry Lee (Connecticut Department of Public Safety) |
