| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| Welcome Reception |
| 6:00 pm | Dinner |
| 7:20 pm | Welcome and Introductory Remarks |
| 7:30 pm - 9:30 pm | New Reactions in Organic Synthesis 1 |
| Discussion Leader: Steve Wittenberger (Abbott Laboratories) |
| 7:30 pm - 8:20 pm | Ed Vedejs (University of Michigan)
"Heteroatom-Directed Hydroboration" |
| 8:20 pm - 8:55 pm | David Barnes (Abbott Laboratories)
"Process Development of Quinolone Antibiotic ABT-492" |
| 8:55 pm - 9:30 pm | Sergey Kozmin (University of Chicago)
"From New Catalytic Reactions to Complex and Diverse Molecular Architecture" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo |
| 9:00 am - 12:30 pm | Organo Metallic Chemistry in Organic Synthesis |
| Discussion Leader: Elaine Lee (MIT) |
| 9:00 am - 9:45 am | David Collum (Cornell University)
"Organolithium Structure-Reactivity Relationships: Challenging Problems from Pharmaceutical Process Research" |
| 9:45 am - 10:30 am | Viresh Rawal (University of Chicago)
"Enantioselective Catalysis of Cycloaddition Reactions" |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Jerry Murry (Merck)
"Synthesis and Development of a Moderately Complex Clinical Candidate" |
| 11:20 am - 11:55 am | Dali Sames (Columbia University)
"Complex Organic Synthesis via C-H Bond Functionalization: New Reactions" |
| 11:55 am - 12:30 pm | Shannon Stahl (University of Wisconsin, Madison)
"Palladium-Catalyzed Aerobic Oxidation Reactions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session #1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Recent Developments in Catalysis |
| Discussion Leader: Margaret Hsu (Abbott Laboratories) |
| 7:30 pm - 8:20 pm | David MacMillan (California Institute of Technology)
"Enamine catalysis, teaching an old dog some new tricks" |
| 8:20 pm - 8:55 pm | Sally Gut (Pfizer)
"Development and Optimization of a Process for a Pyrrolopyrimidine Compound" |
| 8:55 pm - 9:30 pm | Brian Stoltz (California Institute of Technology)
"Recent Developments in Asymmetric Palladium Catalyzed Oxidation and Bond Forming Reactions Inspired by Natural Product Total Synthesis" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | New Reactions in Organic Synthesis 2 |
| Discussion Leader: Karl Scheidt (Northwestern University) |
| 9:00 am - 9:45 am | Shu Kobayashi (The University of Tokyo)
"Towards Truly Efficient and Powerful Organic Synthesis" |
| 9:45 am - 10:30 am | Jonathan Ellman (University of California, Berkeley)
"Efficient New Methods for Carbon-Carbon Bond Formation" |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Kai Rossen (DeGussa)
"New Developments from the Laboratories of a Fine Chemicals Manufacturer" |
| 11:20 am - 11:55 am | Tom Rovis (Colorado State University)
"Stereoselective Methods for the Synthesis of Contiguous Stereocenters" |
| 11:55 am - 12:30 pm | Greg Dake (University of British Columbia)
"Methods Forming Complex Azacyclic Arrays" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time / ORP Golf Classic |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mechanistic Chemistry 1 |
| Discussion Leader: Rodney Parsons (BMS) |
| 7:30 pm - 8:20 pm | Donna Blackmond (Imperial College)
"Mechanistic Studies of Proline-Mediated Reactions" |
| 8:20 pm - 8:55 pm | Ed Delany (BMS)
"Chemistry and Control of N-nitrosamine Impurities in Drug Candidates Possessing Secondary Amines" |
| 8:55 pm - 9:30 pm | Peter Harrington (Roche)
"Synthetic Strategies to Roche NK-1 Receptor Antagonists" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Selectivity and Target Oriented Syntheis |
| Discussion Leader: Lisa Reeder (Pfizer) |
| 9:00 am - 9:45 am | Steven Burke (University of Wisconsin, Madison)
"Exploitation of Local-, Hidden-, and Imposed Symmetry in Target-Oriented Synthesis" |
| 9:45 am - 10:30 am | Scott Rychnovsky (University of California, Irvine)
"New Methods for Natural Product Synthesis" |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Bernhard Breit (Freiburg)
"Controlling Selectivity in Metal-Catalyzed and Metal-Mediated Carbon-Carbon Bond Formation" |
| 11:20 am - 11:55 am | Melanie Sanford (University of Michigan)
"Synthetic Applications and Mechanistic Investigations of Directed C-H Bond Oxidation" |
| 11:55 am - 12:30 pm | Bruce Lu (Boehringer Ingelheim Pharmaceuticals)
"Practical Process for Synthesis of 2,3-Disubstituted Indoles and Polycyclic Indole Alkaloids: Novel Palladium-Catalyzed Inter- and Intramolecular Indolization of 2-Chloroanilines with Internal Alkynes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session #2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Organo Metallic Chemistry in Organic Synthesis 2 |
| Discussion Leader: Margaret Faul (Amgen) |
| 7:30 pm - 8:20 pm | Dick Schrock (Massachusetts Institute of Technology)
"Recent Studies Concerning High Oxidation State Alkylidene and Alkylidyne Complexes" |
| 8:20 pm - 8:55 pm | Wayne Luke (Eli Lilly)
"Development of an Efficient Commercial Synthesis for the Selective Estrogen Receptor Modulator Arzoxifene" |
| 8:55 pm - 9:30 pm | Bill Thurmes (Displaytech)
"Liquid Crystals: A Ubiquitous Oxymoron" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mechanistic Chemistry 2 |
| Discussion Leader: Matt McIntosh |
| 9:00 am - 9:45 am | Daniel Singleton (Texas A&M University)
"Dynamic Effects in Ordinary Organic Reactions in Solution" |
| 9:45 am - 10:30 am | Guy Lloyd-Jones (University of Bristol)
"Stereochemical Aspects of Some Organometallic Processes" |
| 10:30 am - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Michel Journet (Merck)
"Long Term Factory Process for the Production of a Prostaglandin D2 Receptor Antagonist - Unprecedented Asymmetric Hydrogenation of an Indole Exo-Cyclic Trisubstituted a,b-Unsaturated Acid" |
| 11:20 am - 11:55 am | Poster Competition: TBA |
| 11:55 am - 12:30 pm | Poster Competition: TBA |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time / Academic versus Industrial Softball Game; Chairs Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Special Lecture |
| Discussion Leader: Bill Bailey (University of Connecticut) |
| 7:30 pm - 8:05 pm | Poster Competition: TBA |
| 8:05 pm - 8:40 pm | Poster Competition: TBA |
| 8:40 pm - 9:30 pm | Reinhard Hoffmann (Philipps-University Marburg)
"Where are we on our way towards the ideal synthesis?" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
