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Organic Reactions and Processes

Gordon Research Conference

July 16 - 21, 2006
Chair
Vice Chair
Bryant University
1150 Douglas Pike
Smithfield, Rhode Island, United States
 Venue and Travel Information

Conference Description

The 2006 Gordon Research Conference on Organic Reactions and Processes will focus on synthetic organic and organometallic chemistry with an emphasis on synthetic methods, catalysis, drug synthesis and natural product synthesis. The poster sessions continue to be an important part of the conference, detailing the latest in academic and industrial chemistry. We continue the tradition of inviting speakers who will present the best of academic and industrial organic chemistry. In addition to established chemists of international reputation, this year we have a special focus on the excellent chemistry of younger faculty.

Conference Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:30 pmOrganometallics in Synthesis 1
Discussion Leader: Peter Wipf (University of Pittsburgh)
7:30 pm - 7:50 pm Hannah Yu (Lilly)
"Stereoselective Synthesis of Dibenzoxapine Containing Nuclear Hormone Receptor Modulators Using Palladium-catalyzed Cascade Reaction"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Martin Hiersemann (Dortmund)
"Development and Application of the Catalytic Asymmetric Claisen Rearrangement (CAC)"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:20 pm John Hartwig (University of Illinois)
"Discovery and Understanding of New Transition Metal-Catalyzed Reactions"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 10:30 amAsymmetric Synthesis
Discussion Leader: Tarek Sammakia (University of Colorado)
9:00 am - 9:20 am Debra Wallace (Merck)
"Catalytic Asymmetric Reactions in the Synthesis of Complex Drug Targets"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Paul Carlier (Virginia Tech)
"Transiently Non-racemic Enolates: Synthesis of Enantiopure 'Quaternary' Benzodiazepines"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Guigen Li (Texas Tech)
"Asymmetric Halo Aldol Reaction for Tandem X-C/C-C Bond Formations"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
10:45 am - 12:30 pmSynthetic Methodology and Process Research 1
Discussion Leader: Angelika Fretzen (Microbia)
10:45 am - 11:10 am Arun Ghosh (Pfizer)
"Process Research and Scale-up of a Pyrazolotriazine Drug Candidate"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Babak Borhan (Michigan State)
"Use of Ylides in Preparation of 5-Member Ring Heterocycles via One Carbon Homologative Relay Ring Expansion of Epoxy Alcohols and Aziridinols"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm John Porco (Boston University)
"Organic Reactions and Processes Inspired by Complex Natural Products"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #1
6:00 pmDinner
7:30 pm - 9:30 pmOrganometallics in Synthesis 2
Discussion Leader: Lisa McElwee-White (University of Florida)
7:30 pm - 7:50 pm Rai-Shung Liu (National Tsing-Hua University)
"Metal-catalyzed Cycloisomerization of Acyclic Alkynes of Mechanistic and Synthetic Interest"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm David Vicic (University of Arkansas)
"Organometallic Aspects of Alkyl-Alkyl Cross-Coupling Reactions"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:20 pm Hélène Lebel (University of Montreal)
"Catalytic Activation of Nitrogen Derivatives with Transition Metal Complexes"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amSynthetic Methodology and Process Research 2
Discussion Leader: Cecile Savarin (Merck)
9:00 am - 9:20 am John Carey (GlaxoSmithKline)
"Analysis of the Reactions used for the Preparation of Drug Candidate Molecules"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am David Hill (Abbott)
"Scale-up Synthesis of BCL-2 Inhibitor ABT-737"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Allison Frontier (Rochester)
"The Nazarov Cyclization: New Twists"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
10:45 am - 12:30 pmOrganometallics in Synthesis 3
Discussion Leader: Rick Bunt (Middlebury)
10:45 am - 11:10 am Christina White (University of Illinois)
"Hydrocarbon Oxidation Methods for Synthesis"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Daesung Lee (Wisconsin)
"Ene-Yne Coupling Reactions for Synthesis"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Janis Louie (University of Utah)
"Recent Progress in Nickel Catalyzed Cycloaddition Chemistry"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time / ORP Gold Classic
6:00 pmDinner
7:30 pm - 9:30 pmNatural Products Total Synthesis
Discussion Leader: Frank McDonald (Emory)
7:30 pm - 7:50 pm Armen Zakarian (Florida State University)
"Progress toward the Total Synthesis of Pinnatoxin A"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20pm Lawrence Williams (Rutgers University)
"Progress towards the Total Synthesis of Psymberin"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:20 pm Daniel Romo (Texas A&M University)
"Asymmetric Synthesis of Bicyclic Beta-Lactones Inspired by Omuralide and Related Natural Products"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amOrganocatalysis
Discussion Leader: Rick Danheiser (MIT)
9:00 am - 9:20 am Karl Scheidt (Northwestern)
"Recent Developments in Carbene Catalysis"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Ohyun Kwon (UCLA)
"Phosphine Catalysis of Allenes"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Jeffrey Bode (UC Santa Barbara)
"Highly Enantioselective, NHC-Catalyzed Annulation Reactions"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
10:45 am - 12:30 pmSynthetic Methodology and Process Research 3
Discussion Leader: Jean Suffert (CNRS)
10:45 am - 11:10 am Mike Harmata (University of Missouri -Columbia)
"Benzothiazines in Organic Synthesis"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Rod Parsons (BMS)
"Discovery and Development of an Efficient Process for Synthesis of the Tetrazole Core of BMS-317180"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Peter Somfai (Royal Institute of Technology)
"Allylsilanes beyond Sakurai-allylations: Synthetic Approaches towards (+)-Alexine Utilizing a Novel [3+2]-Annulation Reaction"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session #2
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair)
7:30 pm - 9:30 pmSynthetic Methodology and Process Research 4
Discussion Leader: Mukund Sibi (North Dakota State University)
7:30 pm - 7:50 pm Thomas Storz (Amgen)
"Biologic or Small Molecule?? -Multiple Challenges in the Synthesis & Scale-Up of a 20K-PEG-conjugated, Selective Bradykinin B-1 Antagonist"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Greg Dudley (Florida State University)
"Simplifying the Art of Organic Synthesis"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:20 pm Steven Weinreb (Penn State)
"Methodology for Synthesis of Alkaloids"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 10:30 amSynthetic Methodology and Process Research 5
Discussion Leader: Art Harms (Bausch & Lomb)
9:00 am - 9:20 am Bob Grossman (University of Kentucky)
"Catalytic Classical Resolution"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Nathan Yee (Boehringer-Ingelheim)
"Development of a Scalable Synthesis of BILN 2061, a Novel HCV Protease Inhibitor"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Paolo Crotti (University of Pisa)
"Regio- and Stereoselectivity of the Addition Reactions of Nucleophiles to the Diastereoisomeric D-Allal- and D-Galactal-Derived Allyl Epoxides and Aziridines"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
10:45 am - 12:30 pmOrganometallics in Synthesis 4
Discussion Leader: Jackie Milne (Amgen)
10:45 am - 11:10 am Sherry Chemler (SUNY Buffalo)
"Copper(II) Carboxylate Promoted Oxidative Cyclizations: Intramolecular Carboamination and Diamination of Unactivated Olefins"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Laurel Schafer (University of British Columbia)
"A New Class of Enantioselective Olefin Hydroamination Catalysts: Chiral Amidates as Modular Ligands for Early Transition Metals"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Jean-Luc Montchamp (Texas Christian)
"Advances in Phosphorus-Carbon Bond-Forming Reactions"
12:20 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmChair's Reception
6:00 pmDinner
7:30 pm - 9:30 pmPoster Presentations and Featured Speaker
Discussion Leader: Scott Sieburth (Temple)
7:30 pm - 7:50 pm TBA
7:50 pm - 8:10 pm TBA
8:10 pm - 8:30 pm TBA
8:30 pm - 9:20 pm Richard Palmer (University of Alberta)
"Asymmetric Synthesis at the Whole-Organism Level: Development and Evolution of Biological Asymmetries"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDepart

Conference Links

Conference History
Additional Fee Info

Carbohydrates
June 15 - 20, 2025
Heterocyclic Compounds
June 22 - 27, 2025
Natural Products and Bioactive Compounds
July 27 - August 1, 2025
Organic Reactions and Processes (GRS)
July 19 - 20, 2025
Organometallic Chemistry
July 13 - 18, 2025


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