SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff & Jos Brands (conference chair) |
7:40 pm - 9:30 pm | DEVELOPMENT OF NEW CATALYTIC ASYMMETRIC REACTIONS I |
| Discussion Leader: Jeffrey Bode (University of California, Santa Barbara, USA) |
7:40 pm - 8:25 pm | Amir Hoveyda (Boston College, USA)
"Chiral N-Heterocyclic Carbene Metal Complexes: New Frontiers in Asymmetric Catalysis" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Erick Carreira (ETH Zürich, Switzerland)
"Discoveries and Surprises with Small Molecules" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 11:15 am | NEW METHODOLOGY FOR THE SYNTHESIS OF HETEROCYCLES |
| Discussion Leader: Jerry Murry (Amgen, USA) |
9:00 am - 9:30 am | Tim Jamison (Massachusetts Institute of Technology, USA)
"Epoxide Opening Cascades" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | John Werner (Eli Lilly, USA)
"The Role of New Technologies in Defining a Manufacturing Process for PPAR Alpha Agonist LY518674" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Scott Nelson (University of Pittsburgh, USA)
"Reaction and Catalyst Designs for Heterocycle Construction via Nontraditional Cycloadditions" |
10:45 am - 10:55 am | Discussion |
10:55 am | Coffee Break |
11:15 am - 12:30 pm | CATALYSIS AND PROCESS CHEMISTRY |
| Discussion Leader: Todd Nelson (Merck Research Laboratories, USA) |
11:15 am - 11:40 am | Francis Gosselin (Merck Research Laboratories, USA)
"The Development of the Manufacturing Process for Cathepsin K Inhibitor MK-0822" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Matthew Gaunt (University of Cambridge, UK)
"New Catalytic Strategies for Chemical Synthesis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NEW SYNTHETIC METHODS FOR APPLICATION ON LARGE SCALE |
| Discussion Leader: Elizabeth Jarvo (University of California, Irvine, USA) |
7:30 pm - 8:00 pm | Keji Maruoka (Kyoto University, Japan)
"Designer Chiral Phase Transfer Catalysts as Promising Organocatalysts for Practical Asymmetric Synthesis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Martin Karpf (Hoffman-La-Roche, Switzerland)
"The Synthetic Development of the Anti-Influenza Neuraminidase Inhibitor Tamiflu: A Challenge for Synthesis and Process Research" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jeffrey Bode (University of California, Santa Barbara, USA)
"Chiral N-Heterocyclic Carbene Catalyzed, Enantioselective Annulations" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:15 am | NEW STRATEGIES FOR THE SYNTHESIS OF NATURAL PRODUCTS AND PHARMACEUTICALS |
| Discussion Leader: Lutz Ackermann (Georg-August University, Göttingen, Germany) |
9:00 am - 9:30 am | Richmond Sarpong (University of California, Berkeley, USA)
"Strategies Inspired by Seven-Membered Ring Natural Products" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Albert Kruger (Abbott Laboratories)
"Development of a Scalable, Asymmetric Synthesis of a Potent DPP-IV Inhibitor: From Gram to Multi-kilogram Scale" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Jennifer Love (University of British Columbia, Canada)
"Synthesis of Partially Fluorinated Aromatics via Selective C-F Activation" |
10:45 am - 10:55 am | Discussion |
10:55 am | Coffee Break |
11:15 am - 12:30 pm | SYNTHESIS WITH RADICALS AND PROCESS CHEMISTRY |
| Discussion Leader: Michel Coutourier (Bristol Meyers Squibb, Canada) |
11:15 am - 11:40 am | George Moniz (Amgen, USA)
“Development of an Enantio- and Diastereoselective Process for a Novel Therapeutic” |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Samir Zard (Ecole Polytechnique, France)
“Fun with Radicals: A Matter of Lifetime” |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:25 pm - 7:30 pm | Business Meeting (Part 1) |
| (Nomination of 2008 Vice-chair / 2009 Chair candidates) |
7:30 pm - 9:30 pm | ASYMMETRIC REACTIONS AND THEIR ANALYSIS |
| Discussion Leader: Sheryl Wiskur (University of South Carolina, USA) |
7:30 pm - 8:00 pm | Eric Anslyn (University of Texas at Austin, USA)
"Supramolecular Analytical Chemistry, From Conception to Practical Applications" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Dietrich Steinhuebel (Merck Research Laboratories, USA)
"A Practical and Efficient Asymmetric Synthesis of a Merck Drug Candidate" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Alexandre Alexakis (University of Geneva, Switzerland)
"Recent Developments in Copper-Catalyzed Asymmetric Reactions" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:15 am | NEW REACTIONS AND PROCESS DEVELOPMENT |
| Discussion Leader: Hannah Yu (Eli Lilly, USA) |
9:00 am - 9:30 am | Jeffrey Johnson (University of North Carolina, USA)
"New Reactions based on Polarity Reversal" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Lindsay Hobson (Bristol Meyers Squibb, USA)
"Process Development towards a Scaleable Synthesis of a Statin" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Ian Ashworth (AstraZeneca, UK)
"Kinetic Studies of the Deprotection of N-Boc Protected Amines: Evidence of an Unexpected Acid Dependence" |
10:40 am - 10:50 am | Discussion |
10:50 am | Coffee Break |
11:15 am - 12:30 pm | PRACTICAL ORGANIC CATALYSIS |
| Discussion Leader: Jinquan Yu (Brandeis University, USA) |
11:15 am - 11:40 am | Benoit Pugin (Solvias, Switzerland)
"Modularity in New Chiral Ferrocenyl-Based Ligands for Enantioselective Hydrogenation - from Concepts to Production Scale Applications" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Matthias Beller (Rostock Institute for Organic Catalysis, Germany)
"The Development of Practical Catalysts for CC-coupling Reactions" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:20 pm - 7:30 pm | Business Meeting (Part 2) |
| (Election of 2008 Vice-chair / 2009 Chair) |
7:30 pm - 9:30 pm | SYNTHESIS OF NATURAL AND UNNATURAL PRODUCTS |
| Discussion Leader: Ioannis Houpis (Johnson & Johnson, Belgium) |
7:30 pm - 8:00 pm | John Wood (Colorado State University, USA)
"Bridged Polycyclic Natural Products: Inspirational Targets for Total Synthesis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Joel Hawkins (Pfizer, USA)
"Reaction Profiling, Mechanism, and Scale Up" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Christina White (University of Illinois, Urbana Champaign, USA)
"Streamlining Synthesis via C-H Oxidation" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:30 am | CONTROL OF STEREOSELECTIVITY IN SYNTHESIS |
| Discussion Leader: Christina White (University of Illinois, Urbana Champaign, USA) |
9:00 am - 9:30 am | Ben Feringa (University of Groningen, The Netherlands)
"In Control of Chirality" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Stephen Challenger (Pfizer, UK)
"Practical Applications of Asymmetric Hydrogenations for the Manufacture of Pharmaceutical Intermediates" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Joseph Ready (University of Texas SW Medical Center, USA)
"Stereoselective transformations of alkynes" |
10:50 am - 11:00 am | Discussion |
11:00 am | Coffee Break |
11:20 am - 11:30 am | Business Meeting (Part 3) |
| (Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences) |
11:30 am - 12:30 pm | POSTER AWARD PRESENTATIONS |
| Discussion Leader: Gregory Cook (North Dakota State University, USA) |
11:30 am - 11:45 am | Poster Presentation 1: John Grotjahn
"An Alkene Zipper: Bifunctional Catalysis of Selective and Extensive Alkene Isomerization" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Poster Presentation 2: Christiane Grise
"Gold Catalyzed Synthesis of Substituted Tetrahydronaphthalenes" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Poster Presentation 3: Robert Hinkle
"One-Pot, Three-Component Mukaiyama Aldol/Silyl-Prins Reactions to Dihydropyrans" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Chair's Reception |
6:00 pm | Dinner |
7:30 pm - 8:30 pm | DEVELOPMENT OF NEW CATALYTIC ASYMMETRIC REACTIONS II |
| Discussion Leader: Christina White (University of Illinois, Urbana Champaign, USA) |
7:30 pm - 8:20 pm | Eric Jacobsen (Harvard University, USA)
"Cooperative Asymmetric Catalysis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:30 pm | THE CHEMISTRY OF DOPING |
| Discussion Leader: Gregory Cook (North Dakota State University, USA) |
8:30 pm - 9:20 pm | Christiane Ayotte (INRS Institut Armand-Frappier, Canada)
"Urinary steroids profiling in athlete doping controls" |
9:20 pm - 9:30 pm | Discussion and conference closing by Gregory Cook (2007 vice-chair) |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |