SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Synthesis and Metal Catalysis |
| Discussion Leader: Michael Harmata (University of Missouri) |
7:40 pm - 8:25 pm | Tohru Fukuyama (University of Tokyo) "Development of Nosyl Chemistry and Its Application to Total Synthesis" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Barry Trost (Stanford University) "Cycloadditions via TMM-Pd Intermediates: New Strategies for Asymmetric Induction and Total Synthesis" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 10:50 am | Industrial Biotransformations I |
| Discussion Leader: Cathleen Crudden (Queens University) |
9:00 am - 9:30 am | Oliver May (DSM) "Sustainability: From a Need to Reality by Applied Biocatalysis" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Christopher Savile (Codexis) "A Greener, Biocatalytic Manufacturing Route to Sitagliptin" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 12:30 pm | Industrial Biotransformations II |
| Discussion Leader: Tamim Braish (Pfizer) |
10:50 am - 11:20 am | Jake Janey (Merck & Co) "The Development of a Biocatalytic Manufacturing Process for Sitagliptin" |
11:20 pm - 11:30 pm | Discussion |
11:30 am - 12:15 pm | Nick Turner (University of Manchaster) "New Biocatalytic Routes to Chiral Amines and Amino Acids" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session #1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Creating Biosystems and Nanosystems |
| Discussion Leader: Fraser Fleming (Duquesne University) |
7:30 pm - 8:15 pm | Don Hilvert (ETH) "Artificial Aldolases" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Peter Schreiner (Justus-Liebig, Universitaet Giessen) "Molecular Lego with Nanodiamonds" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:45 am | Synthetic Methods and Processes I |
| Discussion Leader: Rod Parsons (BMS) |
9:00 am - 9:25 am | Martin Eastgate (BMS) "Mechanistic Insights into the Pd Catalyzed 1,4-Oxidation of Cyclic 1,3-Dienes" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Shawn Walker (Amgen) "Development of a Practical Enantioselective Conjugate Alkynylation" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 12:30 pm | Synthetic Methods and Processes II |
| Discussion Leader: Rob Dancer (Lundbeck) |
10:45 am - 11:10 am | Mimi Hii (Imperial College) "Atom-Economical Catalytic Processes for Organic Synthesis" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Jon Antilla (University of South Florida) "The Development of Chiral Phosphoric Acid-Catalyzed Reaction Methodology" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Scott Snyder (Columbia University) "Explorations into Alkene Halogenation" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time (Optional Excursion: Golf Classic) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Molecular Catalysis |
| Discussion Leader: Robert Hinkel (College of William and Mary) |
7:30 pm - 8:15 pm | David MacMillan (Princeton University) "New Catalysis Concepts" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Shu Kobayashi (University of Tokyo) "New Possibilities in Catalytic Reactions in Water" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:50 am | Catalysis and Development I |
| Discussion Leader: Michel Coutourier (Omegachem Inc.) |
9:00 am - 9:25 am | Jade Nelson (Pfizer) "Development of an Improved Process for PF¬03185043, a CETP Inhibitor for the Modification of Serum Cholesterol Levels" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Eric Moher (Eli Lilly) "Synthetic Process Development for a Conformationally Restricted Glutamic Acid Analog" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 12:30 pm | Catalysis and Development II |
| Discussion Leader: Neal Anderson (Process Solutions) |
10:50 am - 11:20 am | P. Andrew Evans (University of Liverpool) "New Metal-Catalyzed Cross-Coupling and Carbocyclization Reactions" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Jeff Song (Boehringer-Ingelheim) "Practical Synthesis of Chiral Trifluoromethyl-Containing Compounds" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Jean Suffert (CNRS- Strasbourg) "The 4-exo-dig Cyclocarbopalladation: A powerful Tool for Molecular Complexity" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session #2 |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting: Part I |
| (Nominations for the Next Vice Chair; Discuss Future Site & Scheduling preferences) |
7:30 pm - 9:30 pm | Synthetic Methods |
| Discussion Leader: Remy Angelaud (Medivation) |
7:30 pm - 8:15 pm | Dean Toste (U.C. Berkeley) "Catalysis via Cationic Intermediates" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Justin Dubois (Stanford University) "Catalytic C-H Oxidation: New Insights and Advances" |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting: Part II |
| (Election of the Next Vice Chair; Fill Out Evaluation Forms) |
9:00 am - 11:10 am | Catalysis in Asymmetric Synthesis |
| Discussion Leader: Yi-Yin Ku (Abbot) |
9:00 am - 9:45 am | Scott Denmark (University of Illinois, Urbana) "Inventing and Understanding Catalytic, Enantioselective Reactions" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:40 am | Jim Leighton (Columbia University) "Silicon as a Lewis Acid: New Concepts and New Opportunities for Processable Asymmetric Synthesis" |
10:40 am - 10:50 am | Discussion |
10:50 am - 11:10 am | Coffee Break |
11:10 am - 12:30 pm | Selected Poster Presentations |
| Discussion Leader: Kai Rossen (Sanofi-Aventis) |
11:10 am - 11:30 pm | Poster Talk 1: TBA |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Poster Talk 2: TBA |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Poster Talk 3: TBA |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
2:00 pm - 4:00 pm | Annual Academics vs. Industrial Softball Game |
4:00 pm - 6:00 pm | Chairs Reception |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | At the Interface of Chemistry and Biology |
| Discussion Leader: Richard Hsung (University of Wisconsin, Madison) [2010 ORP GRC Chair] |
7:30 pm - 8:30 pm | Stuart Schreiber (Harvard University) "Organic Synthesis and the Gap Between Scientists' Aspirations and Society's Expectations" |
8:30 pm - 9:00 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |