SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | New Strategies and Synthesis I |
| Discussion Leader: Robert E. Maleczka, Jr (Michigan State University) |
7:40 pm - 8:20 pm | Thomas R. Hoye (University of Minnesota) "Is that a Biomimetic or a Biosynthetic Synthesis?" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Amos B. Smith III (University of Pennsylvania) "Evolution of Anion Relay Chemistry: Construction of Architecturally Complex Natural and Unnatural Products" |
9:10 pm - 9:20 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 10:15 am | Advances in Process Chemistry |
| Discussion Leader: Pascal Dubé (Pfizer) |
9:00 am - 9:30 am | J. Ramon Vargas (Eastman Kodak Company) "Rapid Commercialization of a Novel Heterocyclic Dye" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Shawn Pack (Bristol-Meyers Squibb) "The Application of Mechanistic Insight and First Principles Towards the Development of a Robust, Efficient Process" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Coffee Break |
10:30 am - 12:30 pm | New Strategies and Synthesis II |
| Discussion Leader: Hannah Yu (Eli Lilly and Company) |
10:30 am - 11:00 am | Matthias C. McIntosh (University of Arkansas) "Studies in Complex Molecule Synthesis" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Nancy I. Totah (Syracuse University) "Carbon-Carbon Bond Forming Reactions of 2-Methylenetetrahydropyrans" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | George A. O’Doherty (West Virginia University) "De Novo Synthesis for Carbohydrate Medicinal Chemistry" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I (Rodney L. Parsons (Bristol-Meyers Squibb) - Presiding) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Synthetic Methodologies I |
| Discussion Leader: Rebecca C. Hoye (Macalester College) |
7:30 pm - 8:05 pm | Marisa C. Kozlowski (University of Pennsylvania) "Asymmetric Oxidative Coupling and Claisen Rearrangements" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Joseph M. Fox (University of Delaware) "The Crown Conformation in Catalysts from Chiral Paddlewheel Complexes" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Victor Snieckus (Queens University) "Partnering Aromatic/Heteroaromatic Lithium - Transition Metal Catalyzed Chemistries" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:15 am | New Process Chemistry I |
| Discussion Leader: Norma J. Tom (Exelixis) |
9:00 am - 9:30 am | Kai Rossen (Sanofi-Aventis Deutschland GmbH) "Synthesis of an SGLT Inhibitor" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Robert A. Singer (Pfizer) "Development of Pd-Catalyzed Processes for Industry and Applications to the Synthesis of Axitinib" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Coffee Break |
10:30 am - 12:30 pm | New Asymmetric Catalysis |
| Discussion Leader: Armen Zakarian (University of California-Santa Barbara) |
10:30 am - 11:00 am | Takahiko Akiyama (Gakushuin University) "Development of Chiral Brønsted Acid Catalyzed Reactions" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Gregory R. Cook (North Dakota State University) "Advances in Asymmetric Allylation" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Erik de Vries (Codexis) "Practical, Direct Manufacture of Chiral Amines from Ketones" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Optional Golf Classic |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Synthetic Methodologies II |
| Discussion Leader: Jean Suffert (Université de Strasbourg) |
7:30 pm - 8:05 pm | Jeff Aubé (University of Kansas) "Methods Toward Nitrogen-Containing Compounds" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Tristan H. Lambert (Columbia University) "Reaction Design with Aromatic Ions" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Keisuke Suzuki (Tokyo Institute of Technology) "Annulation and Cyclization Approaches to Polyketide-derived Polycyclic Molecules" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:15 am | New Process Chemistry II |
| Discussion Leader: Douglas E. Frantz (University of Texas-San Antonio) |
9:00 am - 9:30 am | Scott A. May (Eli Lilly and Company) "Asymmetric Synthesis of an ER Beta Agonist and Efforts Toward a Continuous Process" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Paul Bulger (Merck) "How to Make a Tonne of CGRP Antagonist" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Coffee Break |
10:25 am - 10:30 am | Business Meeting: Part I |
| (Nominations for the next Vice Chair) |
10:30 am - 12:30 pm | New Synthetic Methodologies III |
| Discussion Leader: Fei Liu (Macquarie University) |
10:30 am - 11:00 am | Paul E. Floreancig (University of Pittsburgh) "Stereoselective Heterocycle Formation through Oxidative Carbon-Hydrogen Bond Activation" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Pauline Chiu (The University of Hong Kong) "Epoxy Enol Silanes in [4 + 3] Cycloadditions" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Keith A. Woerpel (University of California-Irvine) "New Methods for Stereoselective Synthesis Based Upon the Reactions of Silylenes" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II (Todd D. Nelson (Merck) - Presiding) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Strategies and Synthesis III |
| Discussion Leader: Daesung Lee (University of Illinois-Chicago) |
7:30 pm - 8:05 pm | Scott D. Rychnovsky (University of California-Irvine) "Cyclization Reactions of Anions and Cations" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Weiping Tang (University of Wisconsin-Madison) "Stereoselective Addition of Halogens and Nucleophiles to Unsaturated C-C Bonds" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Michael T. Crimmins (University of North Carolina-Chapel Hill) "Total Synthesis of Heterocyclic Natural Products" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting: Part II |
| (Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 10:40 am | New Strategies and Synthesis IV |
| Discussion Leader: Yi Hsiao (Bristol-Meyers Squibb) |
9:00 am - 9:40 am | Janine Cossy (Laboratoire de Chimie Organique - ESPCI) "A Diversity of Methods for the Synthesis of Heterocyclic Compounds" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:30 am | Dale L. Boger (The Scripps Research Institute) "Vinblastine: Synthetic and Mechanistic Studies" |
10:30 am - 10:40 am | Discussion |
| Coffee Break |
11:00 am - 12:30 pm | Traditional Poster Talks |
| Discussion Leader: Todd D. Nelson (Merck) |
11:00 am - 12:30 pm | Poster Talks: TBA |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Optional Annual Academics vs. Industrial Softball Game (2:00 pm ) / Optional Chair's Reception (4:00 pm - 6:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:00 pm | Exploring the Chemistry of Biotic Interactions |
| Discussion Leaders: Rodney L. Parson (Bristol-Meyers Squibb) |
7:30 pm - 8:30 pm | Jerrold Meinwald (Cornell University) |
8:30 pm - 9:00 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |