SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Novel Synthetic Strategies I |
| Discussion Leader: Tristan Lambert (Columbia University) |
7:35 pm - 8:20 pm | Rick L. Danheiser (Massachusetts Institute of Technology) "New Cycloaddition and Annulation Strategies for the Synthesis of Heterocyclic and Carbocyclic Compounds" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Alexander M. Cruickshank Lecture: Erick M. Carriera (ETH - Zürich) "Stereo -Selective and -Specific Catalytic Reactions: Optically Active Building Blocks for the Synthesis of Pharmaceuticals" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 11:00 am | Novel Synthetic Strategies II |
| Discussion Leader: Neil K. Garg (University of California, Los Angeles) |
9:00 am - 9:40 am | Christopher Vanderwal (University of California at Irvine) "Synthesis of Polycyclic Natural Products" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:30 am | Martin D. Burke (University of Illinois) "Seeking higher-order function via iterative cross-coupling" |
10:30 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:00 am - 12:30 pm | Industrial Process Research I |
| Discussion Leader: Jared Piper (Eli Lilly and Company) |
11:00 am - 11:35 am | Sebastien Lemaire (Janssen-Pharmaceutical Co.) "New C-glycosylation methodology in the manufacture of important therapeutics" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Jared W. Fennell (Eli Lilly and Company) "Process Improvements for the Manufacture of a Complex 6-Oxodecahydroisoquinoline- 3-carboxylate System" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Synthetic Methodologies I |
| Discussion Leader: Victor Snieckus (Queens University) |
7:30 pm - 8:15 pm | Amir H. Hoveyda (Boston College) "New Concepts, Catalysts and Methods for Various Z-Selective Olefin Metathesis Reactions" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Gregory C. Fu (Massachusetts Institute of Technology) "Palladium- and Nickel-Catalyzed Cross-Coupling Reactions of Alkyl Electrophiles" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | New Synthetic Methodologies II |
| Discussion Leader: Vy M. Dong (University of Toronto) |
9:00 am - 9:30 am | Eric M. Ferreira (Colorado State University) "Metal-Catalyzed Directed Functionalizations via New Molecular Scaffolds" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Abigail G. Doyle (Princeton University) "Transition Metal-Catalyzed Methods for the Preparation of Bioactive Motifs" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Tobias Ritter (Harvard University) "Late-Stage Fluorination" |
10:50 am - 11:00 am | Discussion |
11:00 am | Coffee Break |
11:10 am - 12:30 pm | Industrial Process Research II |
| Discussion Leader: Karl Matos (BASF) |
11:10 am - 11:40 am | Vassil Elitzin (GlaxoSmithKline) "Development and Implementation of New Synthetic Routes to Triple Reuptake Inhibitor GSK1360707" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Prashant Deshpande (Bristol-Myers Squibb Co.) "Process Development: Issues and challenges for the Synthesis of Dapagliflozin" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Optional OPRD Golf Classic |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Synthetic Methodologies III |
| Discussion Leader: George O'Doherty (Northeastern University) |
7:30 pm - 8:15 pm | Gary A. Molander (University of Pennsylvania) "Organotrifluoroborates - New Reagents and Reactions" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Melanie S. Sanford (University of Michigan) "New Synthetic Methods for C-H Bond Functionalization" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | Novel Synthetic Strategies II |
| Discussion Leader: Albert DelMonte (Bristol-Myers Squibb Co.) |
9:00 am - 9:45 am | Véronique Gouverneur (University of Oxford) "Molecular Editing with Fluorine" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:30 am | Doug E. Frantz (University of Texas San Antonio) "Divergent Synthetic Pathways from Cationic Vinyl Pd(II)-Complexes" |
10:30 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:00 am - 12:30 pm | Industrial Process Research III |
| Discussion Leader: William F. Kiesman (Biogen Inc.) |
11:00 am - 11:35 am | Feng Xu (Merck and Co.) "The Search for the Manufacturing Process of Telcagepant, a CGRP Receptor Antagonist for the Treatment of Migraine" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | John Ragan (Pfizer) "Development of an Enantioselective Synthesis of Filibuvir, a Hepatitis C Virus (HCV) Polymerase Inhibitor" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting: Part I |
| Nominations for the next Vice Chair and Discuss future Site & Scheduling preferences |
7:30 pm - 9:30 pm | Synthetic and Mechanistic Chemistry |
| Discussion Leader: Amy R. Howell (University of Connecticut) |
7:30 pm - 8:15 pm | Huw M. L. Davies (Emory University) "Stereoselective C-H Functionalization in Organic Synthesis" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | David B. Collum (Cornell University) "Lithium Diisopropylamide/THF/-78 °C: Mechanistic Schadenfreude" |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
7:30 am - 9:00 am | Business Meeting: Part II |
| Fill out Conference Evaluation Forms and Election of the next Vice Chair |
9:00 am - 11:00 am | Industrial Process Research IV |
| Discussion Leader: Yi Yin Ku (Abbott) |
9:00 am - 9:35 am | Philippe Mackiewicz (Sanofi-Aventis) "Semisynthetic Artemisinin: Path to Industrial Production" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Matt Bio (Amgen) "The development of a regio- and stereoselective method of pyridone N-alkylation" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 12:30 pm | Poster Session Seminars |
| Discussion Leader: Scott Sieburth (Temple University) |
11:00 am - 11:20 am | Poster Talk #1 |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Poster Talk #2 |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Poster Talk #3 |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Optional Annual Academics vs. Industrial Softball Game / Optional Chair's Reception (4:00 pm - 6:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Synthetic Methodologies and Featured Speaker |
| Discussion Leader: Jean Suffert (Université de Strasbourg) |
7:30 pm - 8:15 pm | Erik J. Sorensen (Princeton University) "Design and synthesis of molecular scaffolds with anti-infective activity" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Jeffrey I. Seeman (University of Richmond) "The Total Synthesis of Quinine, Cholesterol, Cortisone, Lanosterol, Strychnine, Tetracylines, Colchicine, Reserpine, Lysergic Acid, Chlorophyll, Cephalosporin C, Prostaglandin F2α, Erythromycin and Vitamin B12 - In Honor of R. B. Woodward and his Lighter Side" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |