SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Methodology & Complex Molecules |
| Discussion Leader: Joseph. M. Fox (University of Delaware) |
7:35 pm - 8:25 pm | Marc Snapper (Boston College)
"Asymmetric Functionalizations of Alcohols"
|
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:25 pm | Phil S. Baran (Scripps Research Institute)
"Studies in Natural Product Synthesis"
|
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 11:00 am | Organometallic Reactions |
| Discussion Leader: Gregory R. Cook (North Dakota State University) |
9:00 am - 9:40 am | Chisato Mukai (University of Kanazawa)
"Rh-Catalyzed Ring-Closing between Allene and π-Component"
|
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Cristina Nevado (University of Zürich)
"Mechanistic Dichotomies in Gold Catalysis"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 12:20 pm | Organometallic Reaction & Industrial Processes I |
| Discussion Leader: Laura Anderson (University of Illinois at Chicago) |
11:00 am - 11:30 am | Elizabeth R. Jarvo (University of California Irvine)
"Mechanism-Based Design and Development of Palladium, Silver, and Nickel-Catalyzed Reactions for C-C and C-N Bond Construction" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:10 pm | John Limanto (Merck & Co)
"An Asymmetric Long-term Manufacturing Route to an Active Pharmaceutical Ingredient"
|
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Drug Discovery and Carbohydrates |
| Discussion Leader: Shawn D. Walker (Amgen Inc.) |
7:30 pm - 8:20 pm | Gilles Ouvry (AstraZeneca UK)
"Using Organic Chemistry to Engineer Desirable Properties in Kinase Inhibitors"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Peter H. Seeberger (Max-Planck-Institute of Colloids and Interfaces)
"Continuous flow synthesis of highly complex drug molecules"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:40 am | Transition Metal Catalysts and Molecular Architecture I |
| Discussion Leader: Christopher S. Jeffrey (University of Nevada Reno) |
9:00 am - 9:40 am | Marc Taillefer (Montpellier ENSCM)
"Metal Catalyzed Arylation of Nucleophiles"
|
9:40 am - 9:50 am | Discussion |
9:50 am - 10:30 am | Hideki Yorimitsu (University of Kyoto)
"Synthesis of Heteroaromatics by Utilizing Sulfur and Palladium"
|
10:30 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:10 am - 12:30 pm | Industrial Processes II |
| Discussion Leader: Catherine Faler (ExxonMobil) |
11:10 am - 11:40 am | David A.Walsh (United Therapeutics Corp.)
"Thirty-five Years of Chemical Development for the Commercial Manufacturing Process of Treprostinil, the Active Ingredient in Remodulin® and Tyvaso®"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Stefan Abele (Actelion Pharmaceuticals Ltd)
"From Diels-Alder to Organocatalysis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Optional OPRD Golf Classic |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Transition Metal Catalysts and Molecular Architecture II |
| Discussion Leader: Jimmy Wu (Dartmouth College) |
7:30 pm - 8:20 pm | Mikiko Sodeoka (RIKEN Advanced Science Institute)
"Enantioselective Catalysis Based on Transition Metal Enolate Chemistry and/or Fluorination/ Trifluoro-methylation Reactions"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | James P. Morken (Boston College)
"Stereoselective Organic Synthesis Enabled by the Catalytic Reactions of Boron Reagents"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:40 am | Methodology and Complex Molecule Synthesis II |
| Discussion Leader: Yves Troin (ENSC Clermont-Ferrand) |
9:00 am - 9:40 am | Seth Herzon (Yale University)
"Natural Products Synthesis"
|
9:40 am - 9:50 am | Discussion |
9:50 am - 10:30 am | Jieping Zhu (École Polytechnique Fédérale de Lausanne)
"Total Synthesis of Bioactive Natural Products"
|
10:30 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:10 am - 12:30 pm | Industrial Processes III |
| Discussion Leader: William C. Trenkle (NIH) |
11:10 am - 11:40 am | Travis Remarchuk (Genentech, Inc.)
"Process Development Towards a Manufacturing Route for the AKT Inhibitor GDC-0068"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Albert DelMonte (Bristol-Myers Squibb Co.)
"Route Scouting and Development of BMS-791325, an HCV NS5B Replicase Inhibitor"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting, Part I |
| Nominations for the next Vice Chair; Discuss future Site & Scheduling preferences |
7:30 pm - 9:30 pm | Bioactive Molecules and Organometallic Reactions |
| Discussion Leader: Frank E. McDonald (Emory University) |
7:30 pm - 8:20 pm | Max Malacria (Université Pierre et Marie Curie Paris 6)
"Cascade Reactions using Gold, Platinium or Radicals"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Mohammad Movassaghi (MIT)
"Complex Alkaloid Total Synthesis"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting, Part II |
| Fill out Conference Evaluation Forms; Election of the next Vice Chair |
9:00 am - 10:20 am | Industrial Processes IV |
| Discussion Leader: Michael Willis (University of Oxford) |
9:00 am - 9:30 am | Shu Yu (Pfizer)
"Development of the Manufacturing Route for a 5-Lipoxygenase Inhibitor"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Albert Kruger (Abbott)
"Development of a Practical Asymmetric Synthesis of a TRPV1 Antagonist"
|
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 12:20 pm | Poster Presentations |
| Discussion Leader: Matthew M. Bio (Amgen) |
10:50 am - 11:10 am | Todd Hyster (Colorado State University) |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Jeremy May (University of Houston) |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Donald Watson (University of Delaware) |
12:10 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time / Optional Annual Academics vs. Industrial Softball Game / Optional Chair's Reception (4:00 pm - 6:00 pm) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Asymmetric Catalysis |
| Discussion Leader: Pascal Dube (Nalas Engineering) |
7:30 pm - 8:20 pm | Eric N. Jacobsen (Harvard University)
"Physical-Organic Studies of Hydrogen-Bond Catalysis"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Michael H. Tunick (USDA)
"The Chemistry of Cheese" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |