SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | New Methods in Metal Catalysis |
| Discussion Leader: Sukbok Chang (Korea Advanced Institute of Science and Technology) |
7:40 pm - 8:20 pm | Robert Bergman (University of California, Berkeley)
"Selective Transformations of Organic Compounds Mediated by Transition Metal Complexes" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Ruben Martin (Institute of Chemical Research of Catalonia, Spain)
"Metal-catalyzed activation of inert bonds: new avenues for research" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 11:10 am | Scalable Asymmetry and C-H Activation |
| Discussion Leader: Steven Pfeiffer (Kythera Biopharmaceuticals, Inc.) |
9:00 am - 9:30 am | Keith Fandrick (Boehringer Ingelheim Pharmaceuticals)
"Development of a Scalable Asymmetric Process of a Challenging API: Case Study" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Charles Chase (Eisia Co. Ltd)
"Process Development of the Natural Product-Based Drug Halaven" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:30 am - 11:00 am | Martin Eastgate (Bristol-Myers Squibb)
"The Development of a Short and Efficient Synthesis of a Complex Clinical Candidate" |
11:00 am - 11:10 am | Discussion |
11:10 am - 12:30 pm | Halogenation and Alkylhalogenation |
| Discussion Leader: Robert Grossman (University of Kentucky) |
11:10 am - 11:40 am | Thomas Lectka (Johns Hopkins University)
"A Spectrum of Fluorine Chemistry: From Catalyzed Alkane Fluorination to Fluoronium Ions in Solution" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Armen Zakarian (University of California, Santa Barbara)
"Radical Enolate Haloalkylation Methodology" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Exploring New Reaction Manifolds |
| Discussion Leader: Jeremy May (University of Houston) |
7:30 pm - 8:10 pm | Guy Lloyd-Jones (University of Bristol, UK)
"The Odd Couple" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Scott Miller (Yale)
"Searching for Efficient Reactions on Complex Scaffolds" |
9:10 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Complex Synthetic Problems |
| Discussion Leader: Alfredo Castro (Infinity Pharmaceuticals, Inc) |
9:00 am - 9:30 am | Eric Ashley (Merck)
"Process Development for the Synthesis of Vernakalant: Lessons from Zinc, Boron, and Sitagliptin" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Chris Borths (Amgen, Inc.)
"Synthetic Method Development and its Application to the Synthesis of a S1P1 Agonist" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:40 am - 11:10 am | Jared Piper (Eli Lilly)
"Synthetic Approaches and Process Development of LY2562403" |
11:10 am - 11:20 am | Discussion |
11:20 am - 12:00 pm | Sarah Reisman (Cal Tech)
"New Methods and Strategies for the Total Synthesis of Polycyclic Natural Products" |
12:00 pm - 12:10 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Optional ORP Golf Classic |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Synthesis and Function of Peptides and Proteins |
| Discussion Leader: Vy Dong (University of California, Irvine) |
7:30 pm - 8:10 pm | Jeff Bode (ETH)
"Chemical Protein Synthesis with the KAHA Ligation" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Tom Muir (Princeton University)
"Chromatin: An Expansive Canvas for Chemical Biology" |
9:10 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 9:40 am | Industrial Development of Protein Conjugate Therapeutics |
| Discussion Leader: Chris Borths (Amgen, Inc) |
9:00 am - 9:30 am | Scott Jeffrey (Seattle Genetics)
"Potent Antibody Drug Conjugates for Cancer Therapy" |
9:30 am - 9:40 am | Discussion |
9:40 am - 12:30 pm | New Reactions of Nitrogen |
| Discussion Leader: Anita Maguire (University College Cork, Ireland) |
9:40 am - 10:10 am | Jennifer Schomaker (University of Wisconsin, Madison)
"Chemo- and stereoselective strategies for the synthesis of complex amines"
|
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:30 am - 11:10 am | Ning Jiao (Peking University)
"Highly Efficient Methodologies via Nitrogenation" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Gong Chen (Penn State University)
"New Palladium-Catalyzed C-H Functionalization Strategies for Organic Synthesis" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | New Methods for Complex Architectures |
| Discussion Leader: Jade Nelson (Pfizer) |
7:30 pm - 8:10 pm | Armido Studer (WWU Munster, Germany)
"News about Nitroxides" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Brian Stoltz (Cal Tech)
"Methods for the Synthesis of All-Carbon Quaternary Stereocenters" |
9:10 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 10:50 am | Chemistry with Heterocycles and Cations |
| Discussion Leader: Denise Colby (Gilead Sciences) |
9:00 am - 9:30 am | Jimmy Wu (Dartmouth College)
"New Strategies for the Annulation and Alkylation of Indole and Other Heterocycles" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Mary Watson (University of Delaware)
"Transition Metal Catalysis of Cationic Intermediates and Starting Materials" |
10:10 am - 10:20 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 12:30 pm | Poster Presentations |
| Discussion Leader: Joe Fox (University of Delaware) |
10:50 am - 11:10 am | Poster Talk: Andrew Harned (University of Minnesota) |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Poster Talk: Issac Krauss (Brandeis University) |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Poster Talk: Mark Biscoe (The City College of New York) |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Poster Talk: Jamie Neely (Colorado State University) |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Optional Annual Academics vs. Industrial Softball Game |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cause and Effect in the Chemical Sciences |
| Discussion Leader: Doug Frantz (University of Texas at San Antonio) |
7:30 pm - 8:10 pm | Daniel Singleton (Texas A&M University)
"Case Studies of Reaction Mechanisms: The Importance of Experimental Observation" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Daniel Nocera (Harvard University)
"A Solution to the Global Energy Challenge - The Role of Organic Chemistry" |
9:10 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |