Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | New Synthetic Methods |
| Discussion Leader: Kevin Brown (Indiana University, USA) |
7:40 pm - 8:25 pm | Paul Knochel (Ludwig-Maximilians University, Germany) "Polyfunctional Organometallics in Organic Synthesis" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Scott Denmark (University of Illinois, USA) "Recent Advances in Preparative and Mechanistic Aspects of New Synthetic Methods" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Advances in Catalysis |
| Discussion Leaders: Mark Biscoe (The City College of New York, USA) and Amelie Dion (Pfizer, USA) |
9:00 am - 9:35 am | Michael Willis (University of Oxford, United Kingdom) "Taming Sulfur Dioxide for Synthesis and Catalysis" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Cathleen Crudden (Queen's University, Canada) "Chiral Organo Boranes: Substrates and Catalysts in Organic Transformations" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Guangbin Dong (University of Texas at Austin, USA) "C-H Functionalization Based on Common Functional Groups" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Neil Garg (University of California, Los Angeles, USA) "Recent Advances in Non-Precious Metal Catalysis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Process Development and Structure, Function and Mechanism |
| Discussion Leader: Kami Hull (University of Illinois at Urbana-Champaign, USA) |
7:30 pm - 8:00 pm | Nathan Ide (AbbVie, USA) "Development of a Commercial Manufacturing Process for Ibrance® (palbociclib)" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:35 pm | Kevin Cole (Eli Lilly and Company, USA) "A Case Study in Continuous Processing Under cGMP" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Kendall Houk (University of California, Los Angeles, USA) "Elucidation of Mechanisms and Selectivities of Catalytic Reactions Through Computations" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Chemical Technologies |
| Discussion Leaders: Jennifer Koviach-Cote (Bates College, USA) and Michael Zacuto (Celgene, USA) |
9:00 am - 9:35 am | Emily Balskus (Harvard University, USA) "Biocompatible Chemistry" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Al Garofalo (Catalent Biologics, USA) "Site-Specific ADCs; Linker Composition, Tag Placement, and Bioorthogonal Ligation Strategies" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Suzanne Blum (University of California, Irvine, USA) "Oxyboration: Addition of the B-O Sigma Bond to Carbon-Carbon Pi Bonds" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Shannon Stahl (University of Wisconsin - Madison, USA) "Aerobic Oxidation Reactions for Pharmaceutical (Including Process Scale) Synthesis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Process Development and Catalytic Methods |
| Discussion Leader: Jacqueline Milne (Amgen, USA) |
7:30 pm - 8:00 pm | Jonathan Reeves (Boehringer Ingelheim Pharmaceuticals, USA) "Development of Safe and Scalable Processes for API Synthesis" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:35 pm | Richard Fox (Bristol-Myers Squibb, USA) "Highlights in the Development of a Commercial Synthesis for a Late-Stage Active Pharmaceutical Ingredient" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Karl Scheidt (Northwestern University, USA) "Cooperative Catalysis Strategies for Synthesis" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Synthetic Methods and Strategies |
| Discussion Leaders: Silvia Diez-Gonzalez (Imperial College London, United Kingdom) and Amy DeBaillie (Eli Lilly & Company, USA) |
9:00 am - 9:35 am | Kenichiro Itami (Nagoya University, Japan) "Materials- and Biology-Oriented C-H Activation" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Cristina Nevado (University of Zurich, Switzerland) "If Metals Could Talk..." |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Daniel Weix (University of Rochester, USA) "Cross-Electrophile Coupling via Synergistic Catalysis" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Corey Stephenson (University of Michigan, USA) "Visible Light Mediated Free Radical Chemistry" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Process Development and Non-Precious Metal Catalysis |
| Discussion Leader: Shashank Shekhar (AbbVie, USA) |
7:30 pm - 8:00 pm | Kevin Campos (Merck & Co., Inc., USA) "Application of a Novel Catalytic Asymmetric Reaction to the Manufacture of Elbasvir" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:35 pm | Chong Han (Genentech, Inc., USA) "Harnessing the Reactivity of 7-Azaindole for the Manufacturing Process of a Small Molecule Kinase Inhibitor" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Paul Chirik (Princeton University, USA) "Base Metal Catalysis for Organic Synthesis" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Complex Molecular Synthesis / Selected Poster Presentations |
| Discussion Leaders: Kenneth Fraunhoffer (Bristol-Myers Squibb, USA) and Neal Anderson (Anderson's Process Solutions LLC, USA) |
9:00 am - 9:30 am | Jeremy Wulff (University of Victoria, Canada) "Total Synthesis and Biological Exploitation of Complex Unnatural Products" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Christopher Vanderwal (University of California, USA) "Synthesis of Complex, Bioactive Natural Products" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:35 am | Coffee Break |
10:35 am - 11:05 am | Timothy Jamison (Massachusetts Institute of Technology, USA) "Continuous Flow Multistep Synthesis" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Liela Bayeh (University of Texas Southwestern Medical Center, USA) "Allylic Functionalizations of Unsaturated Hydrocarbons" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | John Tellis (University of Pennsylvania, USA) "Single-Electron Transmetalation: Enabling C(sp3) Cross-Coupling via Photoredox/Nickel Dual Catalysis" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Peter Dornan (California Institute of Technology, USA) "Tandem Olefin Metathesis - Oxidation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Alexander Grenning (University of Florida, USA) "New Opportunities for Ketone-Knoevenagel Adducts" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Ramesh Giri (University of New Mexico, USA) "Copper-Catalyzed Cross-Couplings of Organometallic Reagents and Their Mechanistic Studies" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Chemistry: The Central Science |
| Discussion Leader: Vy Dong (University of California, Irvine, USA) |
7:30 pm - 8:00 pm | Eric Fang (Amgen, USA) "Development of a Robust Process for a C-Met Inhibitor" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:35 pm | Pascal Dube (Nalas Engineering, USA) "Development of Safe and Practical Oxidation Reactions for the Production of Energetic Materials" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Henry Lee (University of New Haven, USA) "Lessons Learned from High Profile Cases" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |