Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Strategies
for Preparing Complex Molecules |
| Discussion Leader: Scott Sieburth (Temple University, USA) |
7:40 pm - 8:05 pm | Kevin Brown (Indiana University, USA) "No Strain, No Gain: Advances in the Synthesis and Use of Cyclobutanes" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | David Waller (Merck & Co. Inc., USA) "The Cross-Coupling Approach to Cephalosporin Antibiotics" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Andre Beauchemin (University of Ottawa, Canada) "Reaction Development Using Temporary Intramolecularity and Amphoteric Isocyanates" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Inspired
by Nature: Biomimetic Syntheses,
Biocatalysis, and Applications of "Large Molecules" |
| Discussion Leaders: Hosea Nelson (University of California, Los Angeles, USA) and Pamela Tadross (Merck & Co. Inc., USA) |
9:00 am - 9:30 am | Thomas Maimone (University of California, Berkeley, USA) "Synthesis of Complex Terpenes from Simple Precursors" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jared Lewis (University of Chicago, USA) "Engineering Proteins for Selective Catalysis" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Robert Linhardt (Rensselaer Polytechnic Institute, USA) "Chemoenzymatic Synthesis of Heparin and Low Molecular Weight Heparins" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | David Entwistle (Codexis Inc., USA) "Enzyme Evolution for Pharmaceutical Manufacture" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Pamela Tadross (Merck & Co. Inc., USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Going
with or Against the Flow: Guidelines and Applications for Continuous-Flow
Operations |
| Discussion Leader: Dominique Hebrault (Mettler Toledo, USA) |
7:30 pm - 8:00 pm | Nicola Pohl (Indiana University, USA) "A Systems Approach to Tackling the Challenges of Carbohydrate Synthesis and Analysis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Klavs Jensen (Massachusetts Institute of Technology, USA) "Automated Organic Chemistry for Screening, Optimization, and Scaling" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Martin Johnson (Eli Lilly and Company, USA) "Applications of Continuous Reactors in Pharmaceutical Manufacturing" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Precious
or Non-Precious Metals: Organometallic
Reagents Using or Avoiding Transition Metals, Precious Metals, and Rare Earth
Elements |
| Discussion Leaders: Jennifer Roizen (Duke University, USA) and Vladimir Gevorgyan (University of Illinois at Chicago, USA) |
9:00 am - 9:30 am | Olafs Daugulis (University of Houston, USA) "New Methods for Carbon-Hydrogen Bond Functionalization" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Donald Watson (Univesity of Delaware, USA) "Recent Progress in Heteroatomic Heck Reactions" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Kami Hull (University of Illinois at Urbana-Champaign, USA) "Transition Metal-Catalyzed Amination and Amidation Reactions" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Veronique Gouverneur (Oxford University, United Kingdom) "Fluorine Chemistry: Chemical, Radiochemical and Clinical Advances" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | From Flask to Reactor:
Strategies and Tactics for Scale-Up |
| Discussion Leader: Sergey Pronin (University of California, Irvine, USA) |
7:30 pm - 8:00 pm | Brenda Burke (Gilead Sciences, Inc., USA) "Process Chemistry Development of Ledipasvir - NS5A Inhibitor in HarvoniĀ® for Hepatitis C Treatment" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Michael Bech Sommer (Awapatent A/S, Denmark) "Courtroom Chemistry and Molecules with a Legal Twist" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Ryan Shenvi (Scripps Research Institute, USA) "Persistence" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Enlightening Tools: Photoredox Catalysis and
Other "One-Electron" Chemistry |
| Discussion Leaders: David Michaelis (Brigham Young University, USA) and Daniele Leonori (The University of Manchester, United Kingdom) |
9:00 am - 9:30 am | Melanie Sanford (University of Michigan, USA) "Recent Developments in Catalytic C-H Functionalization" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Tehshik Yoon (University of Wisconsin-Madison, USA) "A General Strategy for Stereocontrol in Photochemical Reactions" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Robert Knowles (Princeton University, USA) "Proton Coupled Electron Transfer in Organic Synthesis" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | David MacMillan (Princeton University, USA) "The Use of Photoredox Catalysis to Invent or Discover Unique One-Electron Mediated Reactions" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Approaches for Innovative Medicines |
| Discussion Leader: Yi-Yin Ku (AbbVie, USA) |
7:30 pm - 8:00 pm | Nicole Goodwin (GlaxoSmithKline, USA) "Split Kinase Personalities: Type I and Type III Inhibitors of LIMK2" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Thomas Razler (Bristol-Myers Squibb, USA) "Development of the Commercial Synthesis of Gamma Secretase Inhibitor BMS-708163 (Avagacestat)" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Kris Jones (Pfizer, USA) "Development of Ertugliflozin, a Novel SGLT2i Inhibitor: From Sugar to Co-Crystal" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Advances in Catalysis and Reaction Mechanisms |
| Discussion Leaders: Silas Cook (Indiana University, USA) and Matthew Beaver (Amgen, USA) |
9:00 am - 9:30 am | Matthew Meyer (University of California, Merced, USA) "Exploring the Selectivity Problem in Chemistry Using Isotopes" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Jean-Philip Lumb (McGill University, Canada) "Driving Synthesis by Oxidation" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:35 am | Coffee Break |
10:35 am - 11:00 am | Johan Wennerberg (Chemoswed AB, Sweden) "Development of a Practical and Safe Synthesis of ABR-215062" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:35 am | John Limanto (Merck Sharp & Dohme, USA) "Development of a Long-Term Manufacturing Route to an HCV NS5b Inhibitor" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Jill Caputo (University of Rochester, USA) "Teaching an Old Dot New Tricks: The Use of Quantum Dots in Photoredox Catalysis" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Justin Mohr (University of Illinois at Chicago, USA) "Regio- and Stereocontrol with Anions and Radicals" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Alexandr Shafir (Institute of Chemical Research of Catalonia (ICIQ), Spain) "New Concepts for Engaging the Haloarenes in CH Functionalization: Halogen Retention for Downstream Diversification" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: The Mystery of Organic Chemistry: Exploiting Surprises, Molecular Machines,
and Legerdemain |
| Discussion Leader: Travis Remarchuk (Denali Therapeutics, Inc., USA) |
7:30 pm - 8:00 pm | Sergey Pronin (University of California, Irvine, USA) "New Methods and Strategies for the Synthesis of Indole Diterpenes" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Bo Qu (Boehringer Ingelheim Pharmaceuticals, USA) "An Ideal Enantioselective Synthesis for BI 11β-HSD Inhibitor" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Steven Raw (AstraZeneca, United Kingdom) "Osimertinib Mesylate: Process Development and Scale-Up of an API on the Critical Path" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |