Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Reaction Methodology
Discussion Leader: Thomas Snaddon (Indiana University, USA)
7:40 pm - 8:10 pm
Donna Blackmond (Scripps Research Institute, USA)
"Pd-Catalyzed C-H Functionalizations: A Chameleon Changes Color"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Simon Meek (University of North Carolina at Chapel Hill, USA)
"Catalytic Reactions of Diborylalkanes"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Gregory Fu (California Institute of Technology, USA)
"Metal-Catalyzed Coupling Reactions of Alkyl Electrophiles"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Efficient Processes in Drug Development
Discussion Leaders: Amelie Dion (Pfizer Inc, USA) and Richard Pariza (SAJE Pharma, LLC, USA)
9:00 am - 9:30 am
Louis-Charles Campeau (Merck & Co., Inc., USA)
"Adventures in Selective Phosphorylation and Other Reactions You Didn't Know Were Difficult"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Bob Dugger (Pfizer Inc., USA)
"Process Development of Lorlatinib"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Alexander Hurd (Lycera Corp, USA)
"Multi-Kilo Synthesis of a RORg Nuclear Hormone Receptor Agonist"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Stefan Abele (Idorsia Pharmaceuticals, Ltd., Switzerland)
"Development of the Manufacturing Route to Cenerimod – An S1P Receptor 1 Agonist "
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Pamela Tadross (Merck & Co., Inc., USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Precious Metal Catalysis
Discussion Leader: Robert Maleczka (Michigan State University, USA)
7:30 pm - 8:00 pm
John Hartwig (University of California, Berkeley, USA)
"Site-Selective Functionalization with Small and Large Catalysts"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
John Wolfe (University of Michigan, USA)
"Pd-Catalyzed Alkene Difunctionalization Reactions for the Synthesis of Heterocycles and Carbocycles"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Jin-Quan Yu (The Scripps Research Institute, USA)
"Enantioselective and Remote C-H Activation Through Metal Insertions"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Reaction Technologies
Discussion Leaders: Ming-Yu Ngai (State University of New York at Stony Brook, USA) and William Trenkle (U.S. Office of Research Integrity, HHS, USA)
9:00 am - 9:30 am
Marisa Kozlowski (University of Pennsylvania, USA)
"Oxygen Driven Fragment Coupling by Activation of C-H, N-H, and O-H Bonds"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Yongda Zhang (Boehringer Ingelheim Pharmaceuticals, Inc., USA)
"Asymmetric and Catalytic Transformation for BI Drug Development"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Shashank Shekhar (AbbVie, USA)
"Evolution of a Process to Synthesize ABT-333, an HCV Polymerase Inhibitor"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Christopher Uyeda (Purdue University, USA)
"Catalytic Reactions at Metal-Metal Bonds"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Studies of Reaction Mechanism
Discussion Leader: Donna Blackmond (Scripps Research Institute, USA)
7:30 pm - 8:00 pm
Dean Tantillo (University of California, Davis, USA)
"Turning Computational Complications into Opportunities for Reaction Optimization and Design"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Deryn Fogg (University of Ottawa, Canada)
"Ex Detritus, Scientia: Decomposition Pathways in Olefin Metathesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
David Collum (Cornell University, USA)
"Structure-Reactivity-Selectivity Relationships in Alkali Metal Enolates"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthesis of Bioactive Compounds (and Radical Cyclizations)
Discussion Leaders: Catharine Larsen (University of California, Riverside, USA) and Kevin Brown (Indiana University, USA)
9:00 am - 9:30 am
Noah Burns (Stanford University, USA)
"Selective Synthesis of Unusual Lipids"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Jack Norton (Columbia University, USA)
"The Catalysis of Radical Cyclizations Under H2 "
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Dirk Trauner (New York University, USA)
"Complexity from Cascades"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Mikiko Sodeoka (RIKEN, Japan)
"New Approaches to Bioactive Molecules"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Advances in Asymmetric Methods in
Chemical Synthesis
Discussion Leader: Marisa Kozlowski (University of Pennsylvania, USA)
7:30 pm - 8:00 pm
T V Babu Rajanbabu (The Ohio State University, USA)
"Catalytic Enantioselective Vinylation Reactions of Alkenes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Clement Mazet (University of Geneva, Switzerland)
"Late Transition Metals in Selective Isomerizations"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Erick Carreira (ETH Zurich, Switzerland)
"New Insights in Catalysis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development Strategies in Process Research (and Reaction Mechanisms)
Discussion Leaders: Jean Suffert (CNRS, France) and Amy Howell (University of Connecticut, USA)
9:00 am - 9:30 am
Lauren Sirois (Genentech, Inc., USA)
"Process Development for the Multi-Kilogram-Scale Synthesis of an Active Pharmaceutical Ingredient"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Eric Simmons (Bristol-Myers Squibb, USA)
"Process Development and Application of a Pd-Catalyzed Direct Arylation in the Commercial Synthesis of the HCV NS5B Inhibitor Beclabuvir"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Franziska Schoenebeck (RWTH Aachen University, Germany)
"Adventures in Catalysis: From Mechanisms to Applications"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Alison Wendlandt (Harvard University, USA)
"Highly Enantioselective Synthesis of All-Carbon Quaternary Stereocenters via Enantioconvergent SN1 Reaction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Simon Lang (University of Pennsylvania, USA)
"New Methods for Allylation: Radical Decarboxylative Allylation via Dual Catalysis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Michael Hilinski (University of Virginia, USA)
"New Site Selective, Organocatalytic Oxidation and Amination Reactions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Robert Phipps (University of Cambridge, United Kingdom)
"Ion Pair-Directed Regiocontrol in Transition-Metal Catalysis: A Meta-Selective C-H Borylation of Aromatic Quaternary Ammonium Salts"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The Awesome Power of Organic Synthesis
Discussion Leaders: Jeremy May (University of Houston, USA) and Jennifer Albaneze-Walker (Janssen Pharma, Johnson & Johnson, Belgium)
7:30 pm - 8:00 pm
Thomas Hoye (University of Minnesota, USA)
"What's New with the Hexadehydro-Diels-Alder (HDDA) Reaction?"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
Huw Davies (Emory University, USA)
"Catalyst-Controlled C-H Functionalization"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:25 pm
Steve Hanessian (University of Montreal, Canada)
"A World of Collaborations"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure