Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 8:10 pm
"Pd-Catalyzed C-H Functionalizations: A Chameleon Changes Color"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Catalytic Reactions of Diborylalkanes"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Metal-Catalyzed Coupling Reactions of Alkyl Electrophiles"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Efficient Processes in Drug Development
9:00 am - 9:30 am
"Adventures in Selective Phosphorylation and Other Reactions You Didn't Know Were Difficult"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Process Development of Lorlatinib"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Multi-Kilo Synthesis of a RORg Nuclear Hormone Receptor Agonist"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Development of the Manufacturing Route to Cenerimod – An S1P Receptor 1 Agonist "
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Site-Selective Functionalization with Small and Large Catalysts"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Pd-Catalyzed Alkene Difunctionalization Reactions for the Synthesis of Heterocycles and Carbocycles"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Enantioselective and Remote C-H Activation Through Metal Insertions"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Reaction Technologies
9:00 am - 9:30 am
"Oxygen Driven Fragment Coupling by Activation of C-H, N-H, and O-H Bonds"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Asymmetric and Catalytic Transformation for BI Drug Development"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Evolution of a Process to Synthesize ABT-333, an HCV Polymerase Inhibitor"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Catalytic Reactions at Metal-Metal Bonds"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Studies of Reaction Mechanism
7:30 pm - 8:00 pm
"Turning Computational Complications into Opportunities for Reaction Optimization and Design"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Ex Detritus, Scientia: Decomposition Pathways in Olefin Metathesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Structure-Reactivity-Selectivity Relationships in Alkali Metal Enolates"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthesis of Bioactive Compounds (and Radical Cyclizations)
9:00 am - 9:30 am
"Selective Synthesis of Unusual Lipids"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"The Catalysis of Radical Cyclizations Under H2 "
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Complexity from Cascades"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"New Approaches to Bioactive Molecules"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Advances in Asymmetric Methods in
Chemical Synthesis
7:30 pm - 8:00 pm
"Catalytic Enantioselective Vinylation Reactions of Alkenes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Late Transition Metals in Selective Isomerizations"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"New Insights in Catalysis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development Strategies in Process Research (and Reaction Mechanisms)
9:00 am - 9:30 am
"Process Development for the Multi-Kilogram-Scale Synthesis of an Active Pharmaceutical Ingredient"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Process Development and Application of a Pd-Catalyzed Direct Arylation in the Commercial Synthesis of the HCV NS5B Inhibitor Beclabuvir"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Adventures in Catalysis: From Mechanisms to Applications"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Highly Enantioselective Synthesis of All-Carbon Quaternary Stereocenters via Enantioconvergent SN1 Reaction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"New Methods for Allylation: Radical Decarboxylative Allylation via Dual Catalysis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"New Site Selective, Organocatalytic Oxidation and Amination Reactions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Ion Pair-Directed Regiocontrol in Transition-Metal Catalysis: A Meta-Selective C-H Borylation of Aromatic Quaternary Ammonium Salts"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The Awesome Power of Organic Synthesis
7:30 pm - 8:00 pm
"What's New with the Hexadehydro-Diels-Alder (HDDA) Reaction?"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Catalyst-Controlled C-H Functionalization"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:25 pm
"A World of Collaborations"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure