Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Discoveries in Organic Synthesis
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
"Synthesis and Structure Assignment of Natural Products"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Stereocontrolled Cyclizations for Organic Synthesis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Enantioselective Boronate Reactions: Discovery, Catalysis and Mechanism"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Methods in Organofluorine Chemistry
9:00 am - 9:30 am
"C-C Bond Forming Reactions of Dicoordinated Carbocations"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Understanding the Preformed Catalyst Activation Mechanism in Organic Synthesis"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"New Electrophilic Fluoroalkylating Reagents for the Preparation of [18 F]SCF3 and [18 F]SCF2 H-Arenes"
11:10 am - 11:15 am
Discussion
11:15 am - 11:45 am
"Synthetic Biology Approaches to New Chemistry"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Accessing Multifluorinated Arenes via Molecular Sculpting"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modern Synthetic Methodology
7:30 pm - 8:00 pm
"Process Development of GDC-0810 and Stereoselective Formation of Tetrasubstituted Olefins"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Asymmetric Atropisoinduction"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Transition Metal/Radical Hybrid Synthetic Methods"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Catalytic Mechanisms and Theory
9:00 am - 9:30 am
"Development of a Green and Sustainable Manufacturing Process for Gefapixant (MK-7264)"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Stereoselective Synthesis of Alkenes Using Silicon and Sulfone Chemistry"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Insights on the Pd(OAc)2 /Xphos Catalytic System"
11:10 am - 11:15 am
Discussion
11:15 am - 11:45 am
"Arene Coupling Reactions on Solid Porous Pd Catalysts"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Progress Toward the Computational Design of Asymmetric Catalysts"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functionalization of Aromatic Systems
7:30 pm - 8:00 pm
"Dearomative Functionalization with Arenophiles: Methods and Applications"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Combining CH Borylations with Other Chemical Events"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Experimental and Computational Synergy in Catalyst Design for C-H Borylation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Process Chemistry
9:00 am - 9:30 am
"Process Development of GS-5734, an Antiviral Nucleotide Analog for the Treatment of Ebola"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Commercial Manufacture Process Development for Venclexta Under Accelerated Development"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Battling with Triple-O-Seven: Route Scouting and Early Scale-Up"
11:10 am - 11:15 am
Discussion
11:15 am - 11:45 am
"Development of a Commercial Route to the Reversible BTK Inhibitor BMS-986142-01"
11:45 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"Enhancing Laboratory Safety: Principles of Safe Synthetic Chemistry"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Iron(III)-Catalyzed Carbonyl-Olefin Metathesis and Oxygen Atom Transfer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Catalyst Development for Asymmetric Synthesis at Laboratory to Process Scale"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Complex Natural Products as a Driving Force for Discovery in Organic Chemistry"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Organometallic Catalytic Mechanisms
9:00 am - 9:30 am
"Reverse Engineering for Metal-Catalyzed Processes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Life and Death of a Catalyst: Interrogating Deactivation and Leaching Using In Situ and In Operando Techniques"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Dynamic Catalytic Systems for Organic Synthesis and Sustainable Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Electrophilic Concerted Metalation-Deprotonation (eCMD): A Distinct C-H Activation Mechanism that Enables Mild Dehydrogenative Coupling with Functional Group-Dense Heteroarenes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Progress Towards the C19 Diterpenoid Alkaloid Talatisamine"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Enantioselective Organoiodane-Catalyzed Synthesis of Fluorinated Alkyl Halide Building Blocks"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organometallic Catalytic Methods
7:30 pm - 8:15 pm
"Biomimetic Catalysis in Green Organic Transformations"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:10 pm
"Olefin Metathesis Catalysts for the Preparation of Molecules and Materials"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure