Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Methods for Complex Molecule Synthesis
Discussion Leaders: Jennifer Roizen (Duke University, USA) and Sriram Naganathan (Dermira, Inc., USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
Alexander Grenning (University of Florida, USA)
"The Original Cope Rearrangement: Fundamental Studies and Applications in Complex Molecule Synthesis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Amir Hoveyda (Boston College, USA)
"The Concept of Delayed Catalysis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
Paul Wender (Stanford University, USA)
"Function-Oriented Synthesis: The Role of Design and Step/Time Economical Syntheses in Strategies for HIV/AIDS Eradication, Alzheimer's Disease and Cancer Immunotherapy"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transition Metal Catalyzed Methods
Discussion Leaders: Sophie Rousseaux (University of Toronto, Canada) and Neil Strotman (Merck & Co., Inc., USA)
9:00 am - 9:30 am
Jennifer Love (The University of British Columbia, Canada)
"Developing Catalytic Reactions One Step at a Time"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Scott Savage (Bristol-Myers Squibb Company, USA)
"Exploiting a Native Directing Group: Catalytic, Regioselective C-H Arylation in the Synthesis of IKur Inhibitor, BMS-919373"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Kay Brummond (University of Pittsburgh, USA)
"A Synergistic Strategy to Achieve an Asymmetric Pauson-Khand Reaction Using Iterative Synthetic Chemistry and Quantum Mechanics"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Nilay Hazari (Yale University, USA)
"Rational Design of Precatalysts for Cross-Coupling and Related Reactions"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Pamela Tadross (Merck & Co., Inc., USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Hypervalent Iodine Methods
Discussion Leader: Sarah Wengryniuk (Temple University, USA)
7:30 pm - 8:00 pm
Alexandr Shafir (Institute of Advanced Chemistry of Catalonia (IQAC), CSIC, Spain)
"Towards Iterative Iodane-Directed C-H Functionalization of Arenes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Tanja Gulder (Technische Universität München, Germany)
"Hypervalent Iodane Mediated Halogenations: A Versatile Tools for the Exploration of Novel Reactivities"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Greg Hughes (Merck & Co., USA)
"The Development of a Biomimetic Approach to MK-8591"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Process Improvements for Drug Development
Discussion Leaders: Rodney Parsons (Bristol-Myers Squibb, USA) and Kami Hull (University of Texas at Austin, USA)
9:00 am - 9:30 am
Michael Rozema (AbbVie, USA)
"Upadacitinib: Process Development of a JAK1 Inhibitor"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Eric Hansen (Pfizer Inc., USA)
"Development of a Biocatalytic Route to the SMO Inhibitor Glasdegib"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Michael Frederick (Eli Lilly and Company, USA)
"Development of a Manufacturable Route for BACE Inhibitor LY3202626"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Georg Wuitschik (Roche, Switzerland)
"ChemPager and How to Make 37 kg of RG7834"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Use of Biomimetic Methods in Synthesis
Discussion Leader: Alison Narayan (University of Michigan, USA)
7:30 pm - 8:00 pm
Helma Wennemers (ETH Zurich, Switzerland)
"Stereoselective Catalysis with Peptides"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Todd Hyster (Princeton University, USA)
"Radical Biocatalysis: Using Light to Reveal New Enzyme Functions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Eric Slack (Johnson Matthey, USA)
"Advancing Cost Effective Iridium C-H Borylations"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Photoredox Catalysis
Discussion Leaders: Jimmie Weaver (Oklahoma State University, USA) and Thomas Colacot (MilliporeSigma, USA)
9:00 am - 9:30 am
Shu-Li You (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China)
"Recent Progress on Catalytic Asymmetric Dearomatization (CADA) Reactions"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Gary Molander (University of Pennsylvania, USA)
"Single Electron Processes Enabling Organic Synthesis"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Jennifer Roizen (Duke University, USA)
"Alcohol and Amine Derivatives Guide Position-Selective C-H Functionalization Reactions"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Nizar Haddad (Boehringer Ingelheim Pharmaceuticals Inc., USA)
"Novel and Versatile BI-Ligands for Practical Synthesis of APIs"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Synthesis of Complex Molecules
Discussion Leader: Jean Suffert (University of Strasbourg / CNRS, France)
7:30 pm - 8:00 pm
Amos Smith (University of Pennsylvania, USA)
"Recent Synthetic Achievements in the Smith Group at the University of Pennsylvania"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
John Wood (Baylor University, USA)
"Recent Efforts in the Synthesis of Complex Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Sarah Reisman (California Institute of Technology, USA)
"Necessity Is the Mother of Invention: Natural Products and the Chemistry They Inspire"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stereoselective Methods for Synthesis
Discussion Leaders: Thomas Snaddon (Indiana University, USA) and Emma McInturff (Pfizer, USA)
9:00 am - 9:30 am
George O'Doherty (Northeastern University, USA)
"De Novo Asymmetric Natural Product Synthesis: Application to Stereochemical-Structure Activity Relationship (S-SAR) Studies"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Mark Biscoe (The City College of New York, USA)
"Stereospecific Pd-Catalyzed Cross-Coupling Reactions Using Enantioenriched Nucleophiles"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Remy Angelaud (Genentech, USA)
"Development of an Asymmetric Synthetic Process to the IDO Inhibitor Navoximod"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Juliet Macharia (Binghamton University, USA)
"13C Kinetic Isotope Effects Reveal Mechanism of Catalytic Suzuki-Miyaura Coupling (SMC) Reactions"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Yang Yang (California Institute of Technology, USA)
"Biocatalytic Methods for the Enantioselective Synthesis of Diamines"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Valerie Schmidt (University of California, San Diego, USA)
"Radical Atom-Transfer Methods Mediated by Phosphorus(III) Reagents"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Design of Novel Methodology
Discussion Leaders: Craig Merlic (University of California, Los Angeles, USA) and Michael Zacuto (Celgene, USA)
7:30 pm - 8:00 pm
Kazuaki Ishihara (Nagoya University, Japan)
"Rational Design of High-Performance Catalysts Based on Acid-Base Combination Chemistry"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
Jon Tunge (The University of Kansas, USA)
"Decarboxylative Substitution and Elimination Reactions"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:25 pm
David Kingston (Virginia Polytechnic University, USA)
"The History, Chemistry and Biology of Taxol, a Famous Anticancer Natural Product"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure