Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Methods for Complex Molecule Synthesis
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
"The Original Cope Rearrangement: Fundamental Studies and Applications in Complex Molecule Synthesis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"The Concept of Delayed Catalysis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Function-Oriented Synthesis: The Role of Design and Step/Time Economical Syntheses in Strategies for HIV/AIDS Eradication, Alzheimer's Disease and Cancer Immunotherapy"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transition Metal Catalyzed Methods
9:00 am - 9:30 am
"Developing Catalytic Reactions One Step at a Time"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Exploiting a Native Directing Group: Catalytic, Regioselective C-H Arylation in the Synthesis of IKur Inhibitor, BMS-919373"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"A Synergistic Strategy to Achieve an Asymmetric Pauson-Khand Reaction Using Iterative Synthetic Chemistry and Quantum Mechanics"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Rational Design of Precatalysts for Cross-Coupling and Related Reactions"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Hypervalent Iodine Methods
7:30 pm - 8:00 pm
"Towards Iterative Iodane-Directed C-H Functionalization of Arenes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Hypervalent Iodane Mediated Halogenations: A Versatile Tools for the Exploration of Novel Reactivities"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"The Development of a Biomimetic Approach to MK-8591"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Process Improvements for Drug Development
9:00 am - 9:30 am
"Upadacitinib: Process Development of a JAK1 Inhibitor"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Development of a Biocatalytic Route to the SMO Inhibitor Glasdegib"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Development of a Manufacturable Route for BACE Inhibitor LY3202626"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"ChemPager and How to Make 37 kg of RG7834"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Use of Biomimetic Methods in Synthesis
7:30 pm - 8:00 pm
"Stereoselective Catalysis with Peptides"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Radical Biocatalysis: Using Light to Reveal New Enzyme Functions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Advancing Cost Effective Iridium C-H Borylations"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Recent Progress on Catalytic Asymmetric Dearomatization (CADA) Reactions"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Single Electron Processes Enabling Organic Synthesis"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Alcohol and Amine Derivatives Guide Position-Selective C-H Functionalization Reactions"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Novel and Versatile BI-Ligands for Practical Synthesis of APIs"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Synthesis of Complex Molecules
7:30 pm - 8:00 pm
"Recent Synthetic Achievements in the Smith Group at the University of Pennsylvania"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Recent Efforts in the Synthesis of Complex Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Necessity Is the Mother of Invention: Natural Products and the Chemistry They Inspire"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stereoselective Methods for Synthesis
9:00 am - 9:30 am
"De Novo Asymmetric Natural Product Synthesis: Application to Stereochemical-Structure Activity Relationship (S-SAR) Studies"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Stereospecific Pd-Catalyzed Cross-Coupling Reactions Using Enantioenriched Nucleophiles"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Development of an Asymmetric Synthetic Process to the IDO Inhibitor Navoximod"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"13C Kinetic Isotope Effects Reveal Mechanism of Catalytic Suzuki-Miyaura Coupling (SMC) Reactions"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Biocatalytic Methods for the Enantioselective Synthesis of Diamines"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Radical Atom-Transfer Methods Mediated by Phosphorus(III) Reagents"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Design of Novel Methodology
7:30 pm - 8:00 pm
"Rational Design of High-Performance Catalysts Based on Acid-Base Combination Chemistry"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Decarboxylative Substitution and Elimination Reactions"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:25 pm
"The History, Chemistry and Biology of Taxol, a Famous Anticancer Natural Product"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure