Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Stereochemical and Atomic Control in Organic Synthesis
7:40 pm - 8:10 pm
"Copper-Catalyzed Aminofunctionalization of Alkenes and Dienes"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Polarity Inversion Catalysis by the Conjugate Addition of Lewis Bases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
"Stereoselective Synthesis in Stereochemically Fluxional Systems"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Installation and Uses of Halogens
9:00 am - 9:30 am
"Design and Development of a Convergent Synthesis of an Aminoquinoline NLRP3 Agonist"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Development of a Palladium-Catalyzed Aryl Amidation for API Synthesis"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"Technology Solutions to Unlock Access to Challenging Reactions on Scale"
11:05 am - 11:10 am
Discussion
11:10 am - 11:45 am
"Teaching an Old Dog New Tricks: Selenium as a Catalyst for C-H Amination Reactions"
11:45 am - 11:50 am
Discussion
11:50 am - 12:25 pm
"Late-Stage Functionalizations"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovative Strategies in C-C Bond Formation
7:30 pm - 8:05 pm
"En-Light-Ening C–H Functionalization"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
"Site Selective Synthesis of Benzylic Collidinium Salts via Electrochemical C–H Functionalization"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
"Alkyne Functionalization for Use in Organic Synthesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Process Development of Paxlovid: Milligrams to Metric Tons in 18 Months"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant)"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"How a Crystallization Induced Dynamic Resolution Made Lenacapavir Possible"
11:05 am - 11:10 am
Discussion
11:10 am - 11:45 am
"Catalysis with Foldamers"
11:45 am - 11:50 am
Discussion
11:50 am - 12:25 pm
"High-Throughput Enantiopurity Analysis using Enantiomeric DNA-Based Sensors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Behold the Power of Light
7:30 pm - 8:05 pm
"New Avenues in Synthesis via Organic Photoredox Catalysis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
"Recreation by Umpolung: Amide and Peptide Synthesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
"Electrophylic Deborylations in Synthesis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
More C-C Bond Formation and Methods
9:00 am - 9:25 am
"Evolution of Adagrasib’s Commercial Manufacturing Route"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Converting a Biorenewable Solvent into an Active Pharmaceutical Ingredient"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Hybrid Pd-Radical Chemistry: New Mechanism, New Possibilities"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Enantioselective Chemical Synthesis Methods via Cooperative Catalysis"
11:35 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"Synthesis of Neuroprotective Limonoid Natural Products"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
7:30 pm - 8:05 pm
"Understanding, Improving and Controlling Processes by Realtime HPLC"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
"Mapping Catalytic Oxidative Decarboxylative Coupling Reactions"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
"Synthesis Design through the Lens of Flow Chemistry"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:35 am
"Unraveling the Mechanism of Electron Transfer from Samarium(II)-Proton Donor Complexes."
9:35 am - 9:40 am
Discussion
9:40 am - 10:15 am
"Adventures in Flow Chemistry – Towards Continuous Manufacturing of APIs"
10:15 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Accelerating Process Development with Automated Continuous Reactions and Online LC"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemistry on Complex Molecules
7:30 pm - 8:05 pm
"The Use of Natural-Abundance Stable Isotopes in Process Understanding - From Analysis to Synthesis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
"New Catalysts and Concepts for C-C and C-Heteroatom Bond Formation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
"Catalyst Speciation Controls Alkene Functionalization Pathways"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure