Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Transition Metal Catalysis to Generate Complexity and Chirality
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:35 pm
"Cross-Coupling Reactions of Sulfones–Complexity, Chirality and Control"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"New Transition Metal-Catalyzed Transformations for Drug Discovery and Development"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Organometallic Catalysis and Mechanisms
9:00 am - 9:35 am
"Towards Predictive Catalyst Design for Stereoselective C-N Bond Formation"
9:35 am - 9:40 am
Discussion
9:40 am - 10:15 am
"New Developments in Electrosynthesis and Electrocatalysis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Soluble Non-Coordinating Activators for Metallocene Catalysts"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Implementation of a Next Generation Catalyst in the Telomerization of Butadiene to 1-Octene."
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"How a Single Biocatalytic Step Influenced an Entire Process: An Improved Manufacturing Route to Belzutifan"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthesis of Complex Bioactive Molecules
7:30 pm - 8:05 pm
"Strategies for the Step-Efficient Syntheses of Polycyclic Terpenoids"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
"Computationally Augmented Total Synthesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
"Oxygen Driven Fragment Coupling for the Synthesis of Natural Products and Antibacterials"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Catalysis and Process Chemistry
9:00 am - 9:30 am
"Evolution of Improved Route for BMS-986278: Key Strategies, Decisions and Metrics"
9:30 am - 9:35 am
Discussion
9:35 am - 10:05 am
"The Role of Chemical R&D in the Fight Against Covid-19"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:05 am
"Efficient Synthesis of Cardiac Myosin Inhibitor Aficamten for the Treatment of Hypertrophic Cardiomyopathies (HCM)"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Conversion of Benzene to Pyridine via Traceless and Ipso-Selective Nitrene Internalization"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Catalytic Ion Pair Reorganization: Unlocking Phosphonium Dealkylation to Access P-Chiral Compound"
11:45 am - 11:50 am
Discussion
11:50 am - 12:25 pm
"Development of Flexible Catalysts for Organic Synthesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Catalytic Reactions Applied to N-Containing Systems
7:30 pm - 8:05 pm
"Selective Functionalization of Pyridines, Diazines and Pharmaceuticals via Unconventional Intermediates"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
"Alternative Disconnections in N-Heterocycle Synthesis Enabled by Early Transition Metal Catalysis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
"Photochemistry & Organocatalysis: New Radical Opportunities"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Novel Strategies and Methodologies for Synthesis
9:00 am - 9:35 am
"Transfer of Reactive Intermediates from One Molecule to Another"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Development of a Scalable Atroposelective Process to MRTX1719 – An Inhibitor of The PRMT5/MTA Complex"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Preparing for Process Scale Electrochemistry"
11:10 am - 11:15 am
Discussion
11:15 am - 11:45 am
"Mechanism-Driven Improvements to the Manufacturing of KRAS G12C Inhibitor Sotorasib"
11:45 am - 11:50 am
Discussion
11:50 am - 12:25 pm
"Transition Metals and Alternatives in Synthesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Alkene- and Aromatic- Functionalization Reactions
7:30 pm - 8:05 pm
"Biocatalysis and Complex Molecule Synthesis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
"Reactivity and Selectivity Rules in Organic and Organometallic Reactions"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Process Chemistry Research for the Synthesis of Pharmaceuticals
9:00 am - 9:35 am
"Asymmetric Hydrogenation with Chiral Spiro Catalysts"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Process Optimization for the Solid-Phase Peptide Synthesis (SPPS) of Helically-Constrained (Helicon™) Peptides"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Functionalization of Electron-Deficient N-Heterocycles via Direct Excitation of Flavin-Dependent 'Ene'-Reductases"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Enabling the Development of New Brønsted Acid Catalysts Using Data Science"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Organocatalytic Aza Pauson-Khand: A Regioselective Approach to Functionalized 2-Pyrrolines"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Transition State Analysis of Important Reactions in Modern Photoredox Catalysis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metal Catalyzed Reactions and Complex Molecule Synthesis
7:30 pm - 8:05 pm
"Synthesis in a Boron World"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:45 pm
"Heterogeneous Catalysts for Continuous-Flow Fine Chemical Synthesis and Hydrogen Storage/Transport"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
"A Challenge for Total Synthesis ofBioactive Targets: Atom & Step Economy"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure