Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Harnessing the Power of Data to Guide Reaction Optimization
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Machine Learning Strategies for Secondary Sphere Modification in Organocatalysis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Rethinking Fluorine Chemistry with Global Challenges in Mind"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Catalysis: New Tools and Applications
9:00 am - 9:30 am
"New Tools for Organopalladium Catalysis in High-Throughput Experimentation and Beyond"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Controlling Site Selectivity in Pd-Catalyzed Cross-Couplings"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Development and Execution of an Early Phase-Enabling Process for Manufacturing AMG 193 for Phase I Studies"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Synthesis of Securines and Securamines"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Asymmetric Preparation of a Chiral Benzothiazepine API"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"New Base-Promoted Oxidative and Reductive Coupling Reactions"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"New Hydrocarbons as Lynchpins in Step Economic Total Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Leveraging Mechanistic Studies and Kinetic Modeling of Impurity Formation to Fuel Optimization of a Commercial Process Towards a BTK Inhibitor"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Applications-Driven Catalysis
9:00 am - 9:30 am
"Enantioconvergent Redox-Neutral Functionalization of Alcohols via Borrowing Hydrogen Catalysis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Strained Molecule Synthesis Using Palladium Carbenes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"New Directions in Iminium Organocatalysis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Development of Continuous Manufacturing Process for the Pharmaceutical Industry: The Challenges and Applications"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"A Chemoselective Removal of Boc and tBu Groups within Highly N-Alkylated Peptides: An Enabling Technology in the Process Development of "Mid-Sized" Drugs"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"New Strategies for the Synthesis and Functionalization of Small Rings"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Is My Low Yield the Result of a Post-Transition State Bifurcation?"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"The Largest Small Molecule: How Chemistry Enabled the Discovery and Development of PCSK9 Inhibitor MK-0616"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Adventures in Synthesis, Catalysis, and Reaction Discovery
9:00 am - 9:30 am
"Atropisomerism as an Inspiration for New Chemistry"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Breaking Symmetry: Development and Application to Complex Targets"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Asymmetric Reductive Addition of Organic Halides to Polar Double Bonds"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Building Seamless Capabilities with HTE, Automation and Data Architectures"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Evolution of the Stereocontrolled Manufacturing Process to TRPA1 Inhibitor GDC-6599"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Anaerobic Heteroatom Transfer Reactions Promoted by Photoexcited 1,3-Dipoles"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"A Radical Approach to Asymmetric Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Process Development of the NextGen Covid Therapeutic PF-07817883"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Unique Bond-Forming Reactions
9:00 am - 9:30 am
"Deoxygenative Cross-Coupling Reactions"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Natural Product Synthesis and Synthetic Methodology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Structure-Reactivity Relationships of Anomeric Amides in Nitrogen-Deletion Reactions"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"A Ligand Design Inspired by the Mechanistic Study of Transmetalation"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"A Unified Synthetic Strategy for the Construction of Diverse sp3-Rich Heterocycles Enabled by Unconventional Ligand Platforms for Pd"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Recent Advances in Acetal Radical Coupling Reactions"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Visible Light Photoredox Catalysis
7:30 pm - 8:00 pm
"A Redesigned Approach to Accessing Carbocations"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Electrophotocatalysis: Combining Light and Electricity to Promote Reactions"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"New Photocatalytic Reactions That Will Be (Hopefully) Useful to Pharmaceutical Discovery"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure