Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Anionic Cascade Adventures: From Strained Rings to Atropisomers with Fun Discoveries Along the Way"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Stereoselective Reactions with Feedstock Chemicals"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reaction Mechanisms and Strategies in Process Research
9:00 am - 9:30 am
"Synthetic Strategies Leveraging Fluoride-Enabled Reactivity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Iron-Catalyzed Radical Cross-Couplings: A General Platform for Selective Alkene Difunctionalization"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Advancements in Process Chemistry for a KRAS G12C Inhibitor: Refining Synthetic Approaches for Critical Building Blocks and Final Assembly"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Robustness in Chemical Processes: Mechanistic Patterns from Case Studies"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Kinetic and Mechanistic Studies Guide Development of a Scalable Sulfonamide Synthesis for AMG 650"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthesis of Complex Bioactive Molecules
7:30 pm - 8:00 pm
"Development of a Continuous Process and Manufacturing System for the Kilogram-Scale Preparation of an Advanced Drug Substance Intermediate"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Development of an Efficient, Robust Process for Oral PCSK9 Inhibitor MK-0616"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Small Rings Doing Big Jobs: New Routes to Beta-Lactones"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reactions and Processes for a Sustainable Future
9:00 am - 9:30 am
"Biocatalysis for the Masses: Including Enzymes in Your Chemistry"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Chemoenzymatic Synthesis of Medicinally-Relevant, sp3 -Rich Molecules"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Sustainability Improvements for Solid-Phase Peptide Synthesis"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Green-By-Design Development of the Second-Generation Route to Camlipixant"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Your Chemistry Has Got Potential: Highly Reactive Intermediates Without the “Bang”"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalytic and Asymmetric Methods in Chemical Synthesis
7:30 pm - 8:00 pm
"Harnessing Cyclopropenimines for Catalyst Design in Stereoselective Synthesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Nickel-Catalyzed C-N and C-O Cross-Couplings Enabled by DalPhos Ligation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Choose Your Own Adventures in Catalysis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Strategies and Methodologies for Synthesis
9:00 am - 9:30 am
"Synthesis of Nitrogen Heterocycles Through Transition Metal-Catalyzed Heteroarene Dearomatization"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"New Synthetic Methods Using Photochemistry"
10:10 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"The Development of Multi-ton GMP Flow Processes for the Pharmaceutical Industry"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Commercial Route Development of an Active Pharmaceutical Ingredient"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"New Tools in Sulfur-Fluorine Exchange (SuFEx)"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthesis of and with Heterocycles
7:30 pm - 8:00 pm
"Challenges and Opportunities for Large Scale Syntheses of Heterocycles in the Agrochemical Industry"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Deaminative Cross-Couplings"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Radical Approaches to Bond Formation and Selected Poster Talks
9:00 am - 9:30 am
"Photomediated Strategies for Engaging Non-Traditional Radical Precursors in Organic Synthesis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Electrochemical Methods for C–C and C–X Cross Coupling Reactions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Academic Drug Discovery
7:30 pm - 8:20 pm
"The Role of Medicinal Chemistry in the Search for New Therapeutic Agents: Natural Products vs Peptides"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:20 pm
"YCT-529 A Male Contraceptive: The Path from Discovery to the Clinic"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure