SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Current status of Pancreatic diseases and challenges |
| Discussion Leader: Marco Falasca (Barts and The London)
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7:40 pm - 8:20 pm | John Neoptolemos (University of Liverpool)
"New strategies in pancreatic cancer"
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8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Matthias Hebrok (UCSF)
"Generating β cells from stem cells"
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9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:45 am | Group Photo |
9:00 am - 12:30 pm | Pancreatic Models |
| Discussion Leader: Sunil Hingorani (Fred Hutchinson Cancer Research Center) |
9:00 am - 9:30 am | Owen Sansom (Beatson Institute Glasgow)
"Using genetically engineered mouse models to test novel therapeutic targets in PDAC"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Franco Folli (University of Texas Health S. C. at San Antonio)
"Pancreatic Pleiotropic Effects of Exenatide/Exendin-4, a GLP-1 receptor Agonist in the Baboon, a non-Human Primate Model of Obesity and Type 2 Diabetes Mellitus"
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9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Piero Marchetti (University of Pisa)
"The β cell in human type 2 diabetes"
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11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Manuel Hidalgo (Spanish National Cancer Research Centre (CNIO))
"Personalized tumorgrafts"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Jonathan Brody (Thomas Jefferson University)
"HuR post-transcriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Stephan Speier (Technische Universität Dresden)
"Pancreas tissue slice culture facilitates long-term studies of exocrine and endocrine cell physiology in situ"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cell-cell interactions in pancreas |
| Discussion Leader: Bernard Thorens (Lausanne University) |
7:30 pm - 8:00 pm | Christofer Wright (Vanderbilt University)
"Pancreas Development"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Dafna Bar-Sagi (New York University)
"Small GTPases signaling in pancreatic cancer"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Farzad Esni (University of Pittsburgh)
"Macrophage polarization is a necessary element of pancreatic regeneration"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Peter Storz (Mayo Clinic Florida)
"Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia"
|
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular mechanisms of pancreatic diseases |
| Discussion Leader: Maureen Gannon (Vanderbilt University) |
9:00 am - 9:30 am | Donghui Li (University of Texas)
"Obesity and Diabetes as risk factors for pancreatic cancer"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Janel Kopp (University of California San Diego)
"Cellular Origins of Pancreatic Ductal Adenocarcinoma"
|
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Anil Bhushan (UCLA)
"Regeneration of pancreatic islets"
|
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Fred Gorelick (Yale University)
"Effects of extracellular metabolic factors on acute pancreatitis"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Beatriz Sosa-Pineda (St. Jude Children's Research Hospital)
"Prox1 activity is essential for exocrine pancreas development and homeostasis"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Donalyn Scheuner (Eli Lilly & Company)
"Stress Signaling in Beta Cell Function and Metabolic Disease"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Novel Signaling mechanisms in pancreatic diseases |
| Discussion Leader: Michael German (UCSF) |
7:30 pm - 8:00 pm | Per Olof Berggren (Karolinska Institute)
"The Pancreatic Islet as a Signaling Hub"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Susumu Seino (Kobe University)
"Mechanisms of cell signaling in insulin secretion"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Patrick Jacquemin (Université Catholique De Louvain)
"Role of Sox9 in pancreatic cancer"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | George Holz (SUNY Upstate Medical University)
"Molecular Basis of Epac2 Action In Pancreatic Beta Cells"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signaling pathways in pancreatic diseases |
| Discussion Leader: Michele Solimena (University of Dresden) |
9:00 am - 9:30 am | Guy Rutter (Imperial College London)
"Signal Transduction in the pancreatic β cell in health and disease"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Chanse Fyffe (Blizard Institute)
"Pharmacological inhibition of PI3K/PDK1 signaling prevents pancreatic cancer tumor growth"
|
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Ben Stanger (University of Pennsylvania)
"Pancreatic cancer progression"
|
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Howard Crawford (Mayo Clinic Florida)
"Signal transduction pathways in pancreatitis"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Andrea Loipetzberger (University of Salzburg)
"Hedgehog/GLI - EGFR cooperation response genes in tumor-initiating pancreatic cancer cells"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Jen Morton (Cruk Beatson Institute)
"Targeting LOX in Pancreatic Cancer"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Therapies and clinical aspects |
| Discussion Leader: Tania Maffucci (Queen Mary University of London) |
7:30 pm - 8:00 pm | Volker Ellenrieder (University of Marburg)
"NFATc1 transcription factor links inflammation and carcinogenesis in the pancreas"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Gianfranco Delle Fave (University of Rome)
"Pancreatic endocrine tumors"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Brittany Allen (OHSU)
"Phosphatase activation and kinase inhibition as a novel therapeutic strategy for pancreatic cancer"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Kimberly Tremblay (University of Massachusetts, Amherst)
"Identification and assessment of tissues involved in dorsal pancreas specification"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Pancreatic stem cells |
| Discussion Leader: Rohit Kulkarni (Joslin Diabetes Center) |
9:00 am - 9:30 am | Anne Grapin-Botton (Copenaghen University)
"From pancreas progenitors to beta cells: better in 3 dimensions?"
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9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Gabriele Capurso (S. Andrea Hospital, University Of Rome)
"Mechanisms of resistance to targeted therapy in pancreatic endocrine tumours"
|
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Sarah Thayer (Harvard Medical School)
"Pancreatic Duct Glands (PDG): An epithelial progenitor stem cell compartment important in regeneration and cancer"
|
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Diane Simeone (University of Michigan)
"Pancreatic cancer stem cells and relevance to cancer treatments"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Luis Filgueira (University of Fribourg)
"Expression of stem cell markers in beta cells"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Danwei Huangfu (Sloan-Kettering Institute)
"Precision genetics in hPSCs for understanding pancreatic development and disease"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetic and epigenetic aspects |
| Discussion Leader: Channing Der (University of North Carolina) |
7:30 pm - 8:00 pm | Jens Siveke (University of Munich)
"K-Ras driven pancreatic cancer"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Jorge Ferrer (Hospital Clinic Barcelona)
"The epigenetic landscape of beta cells"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Clara Lubeseder-Martellato (Klinikum Rechts Der Isar, Tu Munich)
"Endocytosis drives oncogenic Kras-dependent acinar-ductal metaplasia"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Thomas Wilkie (UT Southwestern Medical Center)
"RGS genes - HTS biomarkers for pancreas development, cancer and diabetes"
|
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |