Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Autoimmunity in Pancreatic Disorders |
| Discussion Leader: Piero Marchetti (Università di Pisa, Italy) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:20 pm | Decio Eizirik (Université Libre de Bruxelles, Belgium) "Pancreatic Beta Cell Autonomous Immunity and the Triggering of Insulitis in Type 1 Diabetes" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Suresh Chari (Mayo Clinic, USA) "Autoimmune Diseases of the Exocrine Pancreas" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Pancreatic Cell Identity |
| Discussion Leader: Diane Simeone (University of Michigan, USA) |
9:00 am - 9:30 am | Lori Sussel (Columbia University, USA) "Transcriptional Mechanisms Regulating Beta Cell Identity" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Danwei Huangfu (Sloan Kettering Institute, USA) "Gene Editing in Human Pluripotent Stem Cells to Study Pancreatic Development and Diabetes" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Francesca Spagnoli (Max Delbrueck Center for Molecular Medicine, Germany) "Pancreatic Development: Cell Fate Choices and Plasticity" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Rebecca Beer (Johns Hopkins University, USA) "Centroacinar Cells Are Progenitors that Contribute to Endocrine Pancreas Regeneration" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Heiko Lickert (Helmholtz Zentrum Muenchen GmbH, Germany) "Beta Cell Development and Heterogeneity" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Jin Li (CeMM GmbH, Austria) "An Approved Drug Induces a Beta-Like Phenotype in Alpha Cells" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Adaption of Beta Cells to Hyperglycemia |
| Discussion Leader: Anke Schulte (Sanofi Frankfurt, Germany) |
7:30 pm - 8:00 pm | Yuval Dor (Hebrew University - Hadassah Medical School, Israel) "Mechanisms of Pancreatic Beta Cell Growth and Failure" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Rohit Kulkarni (Harvard Medical School, USA) "Approaches to Enhance Functional Beta Cell Mass" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Alan Attie (University of Wisconsin - Madison, USA) "Genes from Mouse Genetics that Affect the Insulin Secretory Pathway" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Inflammation in Pancreatic Diseases |
| Discussion Leader: Fred Gorelick (Yale School of Medicine, USA) |
9:00 am - 9:30 am | Minoti Apte (University of New South Wales, Australia) "Pancreatic Stellate Cells: Key Roles in Acute and Chronic Pancreatitis" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Shannon Liudahl (Oregon Health and Science University, USA) "B Cells Regulate Tissue Damage During Pancreatitis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Marina Pasca di Magliano (University of Michigan, USA) "Oncogenic Kras and the Pancreatic Cancer Microenvironment" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Jacques Izard (Forsyth Institute, USA) "Multisites Oral Microbiome Investigation of Pancreatitis and Neoplasms of Extrahepatic Bile Duct and Pancreas" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Gregory Beatty (University of Pennsylvania, USA) "Immunoregulatory Networks in Pancreatic Carcinoma" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Elsie Foglio (Yale University School of Medicine, USA) "Effects of NSAIDS (Salicylate Derivatives) on AMP-Activated Kinase Activity in an In Vitro Model of Acute Pancreatitis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | News on Endocrine and Exocrine Secretion |
| Discussion Leader: Mike German (University of California, San Francisco, USA) |
7:30 pm - 8:00 pm | Herbert Gaisano (University of Toronto, Canada) "Role of Inhibitory SNAREs in Secretion in the Endocrine and Exocrine Pancreas" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Regina Kuliawat (Albert Einstein College of Medicine, USA) "The GEFs Kalirin/Trio Contribute to Beta-Granule Remodeling and Exocytosis" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:00 pm | Tetsuro Izumi (Institute for Molecular and Cellular Regulation, Gunma University, Japan) "Novel Functions of Rab27 Effector Proteins in Insulin Granule Exocytosis" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Florian Ehehalt (Technische Universität Dresden, Germany) "Blood Glucose Homeostasis in the Course of Partial Pancreatectomy – Evidence for Surgically Reversible Diabetes Induced by Cholestasis" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genomics and Genetics of Pancreatic Diseases |
| Discussion Leader: Tom Wilkie (University of Texas Southwestern Medical Center, USA) |
9:00 am - 9:30 am | Andrew Biankin (University of Glasgow, United Kingdom) "Clinical Application of Cancer Genomes" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Yiannis Drosos (St Jude Children's Research Hospital, USA) "ATM Loss and KrasG12D Cooperate to Promote Widely Metastatic Pancreatic Ductal Adenocarcinoma in Mice" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Andrew Hattersley (University of Exeter, United Kingdom) "Insights into Pancreatic Development and Function from Gene Discovery in Neonatal Diabetes" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Amita Tiyaboonchai (University of Pennsylvania, USA) "The Role of GATA6 in Human Endoderm and Pancreatic Development from Human Pluripotent Stem Cells" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Marco Falasca (Curtin University, Australia) "The LPI/GPR55 Axis as a Therapeutic Target in Pancreatic Cancer" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Nathan Krah (University of Utah, USA) "PTF1A Limits Pancreatic Tumor Initiation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Pancreas Development and Pancreatic Diseases |
| Discussion Leader: Christopher Wright (Vanderbilt University Medical Center, USA) |
7:30 pm - 8:00 pm | Steven Leach (Memorial Sloan Kettering Cancer Center, USA) "Reciprocal Cell-Cell Signaling in Pancreatic Cancer Initiation" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Maike Sander (University of California, San Diego, USA) "Location Matters: The Underappreciated Role of Niche Cues in Pancreas Morphogenesis and Cell Fate Determination" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Mike German (University of California, San Francisco, USA) "Growth of the Pancreatic Endocrine Compartment" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Insight into Pancreatic Cancer |
| Discussion Leader: Andrew Biankin (University of Glasgow, United Kingdom) |
9:00 am - 9:30 am | Teresa Brentnall (University of Washington, USA) "Molecular Susceptibility to Pancreatic Cancer" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Heather Schofield (University of Michigan, USA) "Bmi1 Is Required for the Initiation of Pancreatic Cancer Through an Ink4a-Independent Mechanism" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 11:00 am | Michael Hollingsworth (University of Nebraska Medical Center, USA) "Molecular Features of Pancreatic Cancer Progression to Metastasis" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Nilotpal Roy (University of California, San Francisco, USA) "Functional Switch in Brg1 Activity Between Benign and Malignant Stages of Pancreatic Ductal Adenocarcinoma" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Andrew Rhim (University of Michigan Medical School, USA) "Single Nucleotide Variants in mRNA in Pancreatic Cancer" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Audrey Hendley (Johns Hopkins University, USA) "p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Novel Approaches for Pancreatic Research |
| Discussion Leader: Howard Crawford (University of Michigan, USA) |
7:30 pm - 8:00 pm | Anne Grapin-Botton (DanStem, University of Copenhagen, Denmark) "Individual Cell Contributions to Pancreas Organogenesis: Stochasticity, Heterogeneity and Self-Organization" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Maureen Anne Gannon (Vanderbilt University Medical Center, USA) "Modulation of Intrinsic and Extrinsic Beta Cell Characteristics to Promote Replication and Regeneration" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Sunitha Nagrath (University of Michigan, USA) "Microfluidic Technologies for Liquid Biopsy: Emerging Tools for Isolation, Characterization and Expansion of CTCs" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |