Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Tackling Pancreatic Diseases
Discussion Leaders: Maike Sander (University of California, San Diego, USA) and Diane Simeone (NYU Langone Medical Center, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Domenico Accili (Columbia University, USA)
"Diabetes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Aida Habtezion (Stanford University, USA)
"Pancreatitis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Sunil Hingorani (Fred Hutchinson Cancer Research Center, USA)
"Pancreatic Cancer"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Plasticity in the Pancreas
Discussion Leaders: Jens Siveke (German Consortium for Translational Cancer Research (DKTK) / Essen University Hospital, Germany) and Francesca Spagnoli (Max Delbrueck Center for Molecular Medicine, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Qiao Zhou (Harvard University, USA)
"Cell Plasticity and Reprogramming"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Howard Crawford (University of Michigan, USA)
"Acinar-to-Ductal Mataplasia: Forms and Functions"
10:00 am - 10:10 am
Discussion
10:10 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:10 am
Jennifer Bailey (University of Texas Health Science Center at Houston, USA)
"Targeting Ras Driven Cellular Heterogeneity for the Treatment of Pancreatic Cancer"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Selected from Poster Abstracts: Christina Adams (University of California, San Francisco, USA)
"Identifying Drivers of Tumor Heterogeneity in Pancreatic Cancer"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Hui-Ju Wen (University of Michigan, USA)
"Macrophage-Derived HB-EGF Contributes to Pancreatic Tissue Recovery"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts: Cristina Aguayo-Mazzucato (Joslin Diabetes Center / Harvard Medical School, USA)
"Insulin Resistance and Diabetes Increases Aging Markers in Rodent and Human Beta Cells"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation in Disease: Diabetes, Pancreatitis and Cancer
Discussion Leaders: Zobeida Cruz-Monserrate (The Ohio State University, USA) and Michael Hollingsworth (University of Nebraska Medical Center, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Marc Donath (University Hospital of Basel, Switzerland)
"Islet Inflammation: From Physiology to Type 2 Diabetes"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Craig Logsdon (University of Texas MD Anderson Cancer Center, USA)
"Inflammation Outcomes Are Determined by Genetic Settings"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Francisco Real (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre, Spain)
"A Genomic View Linking Differentiation and Inflammation in the Exocrine Pancreas"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem/Progenitor Cells in the Pancreas
Discussion Leaders: Lewis Murtaugh (University of Utah, USA) and Beatriz Sosa-Pineda (Feinberg School of Medicine, Northwestern University, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Farzad Esni (University of Pittsburgh, USA)
"Characterization of Pancreatic Multipoint Cells Following Injury"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Tannishtha Reya (University of California, San Diego, USA)
"Pancreatic Cancer Stem Cells"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Senthil Muthuswamy (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Pancreatic Tumor Organoids for Translational Research"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Selected from Poster Abstracts: Patrick Jacquemin (Université Catholique de Louvain, Belgium)
"Combining Oncogenic Kras Mutation and LKB1 Inactivation in Pancreatic Ductal Cells Reveals that Intraductal Papillary Mucinous Neoplasms Originate from Pancreatic Duct Glands"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Selected from Poster Abstracts: Lidong Wang (New York University School of Medicine, USA)
"ATDC Is Required for the Early Initiation of KRAS-Induced Pancreatic Tumorigenesis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Selected from Poster Abstracts: Kamini Singh (Memorial Sloan Kettering Cancer Center, USA)
"Targeting eIF4A Dependent Translation as Therapeutics in Pancreatic Cancer"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genomics in Pancreatic Disease
Discussion Leaders: Eric Collisson (University of California, San Francisco, USA) and Raymond Macdonald (University of Texas Southwestern Medical Center, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Brian Wolpin (Dana-Farber/Brigham and Women's Cancer Center, USA)
"Using Genomics to Personalize Care for Pancreatic Adenocarcinoma"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Talia Golan (Sheba Medical Center, Israel)
"The DDR Subtype in Pancreatic Cancer Discussion"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Kevin White (University of Chicago, USA)
"Genomic Insights from Clinical Patterns and Personalized Models"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regeneration of the Endocrine Pancreas
Discussion Leaders: Rohit Kulkarni (Harvard Medical School, USA) and Michele Solimena (Paul Langerhans Institute Dresden, Germany)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Laura Alonso (University of Massachusetts Medical School, USA)
"Systemic Insulin Demand Regulates Pancreatic Beta Cell Proliferation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Mark Huising (University of California, Davis, USA)
"Virgin Beta Cells Persist Throughout Life at a Neogenic Niche Within Healthy Pancreatic Islets"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Matthias Hebrok (University of California, San Francisco, USA)
"Maturation of Human Stem Cell Derived Beta Cells"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
Selected from Poster Abstracts: Evans Quilichini (Université Pierre-et-Marie-Curie (Paris VI), France)
"Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis and Leads to Pancreatitis and Neoplasia"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Selected from Poster Abstracts: Anguraj Sadanandam (Institute of Cancer Research (ICR), United Kingdom)
"Multi-Omics and Cross-Species Subtypes in Pancreatic Neuroendocrine Tumors with Distinct Cellular Origin, Pathophysiology, Metabolism and Clinical Characteristics"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Selected from Poster Abstracts: Olov Andersson (Karolinska Institutet, Sweden)
"Inhibition of Cdk5 Promotes β-Cell Differentiation from Ductal Progenitors in Zebrafish and Mouse/Human Stem Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Pancreatic Microenvironment
Discussion Leaders: Marina Pasca di Magliano (University of Michigan, USA) and Yuliya Pylayeva-Gupta (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Jen Morton (CRUK Beatson Institute, United Kingdom)
"Targeting Myeloid Cells in Pancreatic Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Gregory Beatty (University of Pennsylvania, USA)
"Mechanisms Regulating a Pro-Metastatic 'Soil' that Supports Pancreatic Cancer 'Seeding'"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Monte Winslow (Stanford University, USA)
"Blimp 1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Mechanisms of Cellular Communication
Discussion Leaders: Rosalie Sears (Oregon Health and Science University, USA) and David Dawson (University of California, Los Angeles, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Daniel Marks (Oregon Health and Science University, USA)
"Signaling Pathways in PDAC Associated Cachexia"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Mike German (University of California, San Francisco, USA)
"Physiologic Regulation of Beta-Cell Turnover"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
Alec Kimmelman (NYU Langone Medical Center , USA)
"Identifying Metabolic Dependencies in Pancreatic Cancer"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:30 am
Selected from Poster Abstracts: Juntaro Matsuzaki (National Cancer Center Research Institute, Japan)
"In Vitro Chemically-Induced Reprogramming of Pancreatic Acinar Cells to Pancreatic Progenitor-Like Cells"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Selected from Poster Abstracts: Jungsun Kim (University of Pennsylvania, USA)
"Developing a Plasma Marker Panel to Detect Pancreatic Ductal Adenocarcinoma"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Selected from Poster Abstracts: Alexander Kleger (Ulm University, Germany)
"ATM-Deficiency Generates Genomic Instability in Pancreatic Ductal Adenocarcinoma and Sensitizes Toward Therapeutic DNA-Damage"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Metabolism
Discussion Leaders: Rushika Perera (University of California, San Francisco, USA) and Gina DeNicola (Moffitt Cancer Center, USA)
5:30 pm - 5:45 pm
Introduction by Discussion Leader
5:45 pm - 6:05 pm
Nabeel Bardeesy (Massachusetts General Hospital, USA)
"Metabolic Heterogeneity in KRAS Mutant Pancreatic Cancer"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:35 pm
Nada Kalaany (Boston Children's Hospital / Harvard Medical School, USA)
"Metabolic Dependencies in Obesity-Associated Pancreatic Cancer"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Costas Lyssiotis (University of Michigan , USA)
"Stromal Support of Pancreatic Tumor Metabolism"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure