Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Environmental Influences on Pancreatic Tissue Homeostasis
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Cellular Senescence in Tissue Damage and Repair"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Metabolic Regulation of Beta Cell Stress"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Tumor Immunology in the Pancreas"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Role of the Microenvironment in Pancreatic Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Endocrine-Exocrine Signaling and PDAC Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Cellular Senescence and Diabetes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Targeting the Metabolic Rewiring of PDAC to Limit Its Progression Towards a Metastatic Disease"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Lgr5-Derived Tuft and Goblet Cells Migrate into the Intrapancreatic Ductal System Following Injury"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Tuft Cells Inhibit Pancreatic Tumorigenesis Through Paracrine Lipid Signaling"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Sensory Neuromodulation of Pancreatic β Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovative In Vivo and In Vitro Models
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Modulators of Glucose Homeostasis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Teaming with Microbes to Build Beta Cell Mass: Lessons from the Zebrafish"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetics of Pancreatic Diseases
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Making Sense of Genome-Wide Association Studies for Pancreatic Cancer Risk"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 11:00 am
"Origins of Molecular Subtypes of Pancreatic Cancer"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Longevity of Beta Cells and Protein Complexes Revealed by Isotope Imaging "
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Inability to Repair Spontaneous DNA Damage in β-Cells Is Sufficient to Drive β-Cell Dysfunction and Features of Type 2 Diabetes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Mutations in RABL3 Alter KRAS Intracellular Trafficking and Are Associated with Familial Pancreatic Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Plasticity in the Pancreas
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Origins of Pancreatic Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Cellular Origins of PDAC"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Mechanisms Underlying Epithelial-Mesenchymal Plasticity in the Pancreas"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Communication in Pancreatic Homeostasis and Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Neuronal Signaling in Islet Development and Function"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"The Role of Nerves in Pancreatic Adenocarcinoma"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Intra-Islet and Extra-Islet Cell Signaling"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"The Glycan CA19-9 Promotes Pancreatitis and Pancreatic Cancer"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Mutant Kras Co-Opts a Progenitor-Associated Transcriptional Network to Drive Pancreatic Tumorigenesis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Homeostatic Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Purinergic Signals from Beta Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Immune Cell-Tissue Cell Interactions
5:30 pm - 5:45 pm
Introduction by Discussion Leader
5:45 pm - 6:05 pm
"Role of Macrophages in Islet Niche"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:35 pm
"Oncogenic Kras and the Cellular Cross-Talk in the Pancreatic Cancer Microenvironment"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Molecular Determinants of PDAC"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Signaling Cascades in Pancreatic Physiology and Pathology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Role of Metabolism in Pancreatic Cancer Progression"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Human Beta Cell Proliferation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"A Novel Scavenger Receptor of the Insulin Signaling Pathway in the Pancreas"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
"TET Hydroxylases Facilitate Pancreatic Endocrine Specification Through Modulating the Activity of Lineage-Specific Enhancers"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"A Switch in Nutrient Sensing Controls Glucose Responsiveness of Pancreatic Beta Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Programming and Reprogramming in the Pancreas
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Pancreatic Cell Reprogramming: Cell Fate Choices and Plasticity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Understanding Pancreatic Cancer Heterogeneity"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Reprogramming and Re-Reprogramming Acinar Cells: Ptf1a and Its Allies as Gatekeepers of Plasticity"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure