Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Environmental Influences on Pancreatic Tissue Homeostasis
Discussion Leaders: Diane Simeone (NYU Langone Medical Center, USA) and Maureen Gannon (Vanderbilt University Medical Center, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
Manuel Serrano (IRB Barcelona, Spain)
"Cellular Senescence in Tissue Damage and Repair"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Yuval Dor (Hebrew University Hadassah Medical School, Israel)
"Metabolic Regulation of Beta Cell Stress"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
David DeNardo (Washington University in St. Louis, USA)
"Tumor Immunology in the Pancreas"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Role of the Microenvironment in Pancreatic Disease
Discussion Leaders: Alejandro Caicedo (University of Miami, USA) and Rohit Chandwani (Weill Cornell Medicine, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
James Johnson (University of British Columbia, Canada)
"Endocrine-Exocrine Signaling and PDAC Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Anil Bhushan (Diabetes Center, University of California, San Francisco, USA)
"Cellular Senescence and Diabetes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Sophie Vasseur (French Institute of Health and Medical Research (INSERM), France)
"Targeting the Metabolic Rewiring of PDAC to Limit Its Progression Towards a Metastatic Disease"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
Selected from Poster Abstracts: Andrew Liss (Massachusetts General Hospital / Harvard Medical School, USA)
"Lgr5-Derived Tuft and Goblet Cells Migrate into the Intrapancreatic Ductal System Following Injury"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Kathleen DelGiorno (The Salk Institute for Biological Studies, USA)
"Tuft Cells Inhibit Pancreatic Tumorigenesis Through Paracrine Lipid Signaling"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Abdelfattah El Ouaamari (The Child Health Institute of New Jersey, USA)
"Sensory Neuromodulation of Pancreatic β Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Rejji Kuruvilla (Johns Hopkins University, USA) and Marina Pasca di Magliano (University of Michigan, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovative In Vivo and In Vitro Models
Discussion Leaders: Mara Sherman (Oregon Health & Science University, USA) and Barak Blum (University of Wisconsin-Madison, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Didier Stainier (Max Planck Institute for Heart and Lung Research, Germany)
"Modulators of Glucose Homeostasis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Danwei Huangfu (Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, USA)
"Human Stem Cell Models"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Karen Guillemin (University of Oregon, USA)
"Teaming with Microbes to Build Beta Cell Mass: Lessons from the Zebrafish"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetics of Pancreatic Diseases
Discussion Leaders: Michele Solimena (Technische Universität Dresden, Germany) and Rushika Perera (University of California, San Francisco, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Kyle Gaulton (University of California, San Diego, USA)
"GWAS of Diabetes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Laufey Amundadottir (National Cancer Institute, NIH, USA)
"Making Sense of Genome-Wide Association Studies for Pancreatic Cancer Risk"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 11:00 am
Faiyaz Notta (Princess Margaret Cancer Centre, Canada)
"Origins of Molecular Subtypes of Pancreatic Cancer"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
Selected from Poster Abstracts: Rafael Arrojo e Drigo (Salk Institute for Biological Studies, USA)
"Longevity of Beta Cells and Protein Complexes Revealed by Isotope Imaging "
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Janine Kruit (University Medical Center Groningen, The Netherlands)
"Inability to Repair Spontaneous DNA Damage in β-Cells Is Sufficient to Drive β-Cell Dysfunction and Features of Type 2 Diabetes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Sahar Nissim (Brigham and Women's Hospital / Dana-Farber Cancer Institute, USA)
"Mutations in RABL3 Alter KRAS Intracellular Trafficking and Are Associated with Familial Pancreatic Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Plasticity in the Pancreas
Discussion Leaders: Frederic Lemaigre (Université Catholique de Louvain, Belgium) and Mark Huising (University of California, Davis, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Steven Artandi (Stanford University, USA)
"Origins of Pancreatic Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Janel Kopp (University of British Columbia, Canada)
"Cellular Origins of PDAC"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Ben Stanger (University of Pennsylvania, USA)
"Mechanisms Underlying Epithelial-Mesenchymal Plasticity in the Pancreas"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Communication in Pancreatic Homeostasis and Disease
Discussion Leaders: Beatriz Sosa-Pineda (Feinberg School of Medicine, Northwestern University, USA) and Christine Chio (Columbia Unversity, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Rejji Kuruvilla (Johns Hopkins University, USA)
"Neuronal Signaling in Islet Development and Function"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Timothy Wang (Columbia University, USA)
"The Role of Nerves in Pancreatic Adenocarcinoma"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Alvin Powers (Vanderbilt University Medical Center, USA)
"Intra-Islet and Extra-Islet Cell Signaling"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
Selected from Poster Abstracts: Dannielle Engle (The Salk Institute for Biological Studies, USA)
"The Glycan CA19-9 Promotes Pancreatitis and Pancreatic Cancer"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Charles David (Tsinghua University, China)
"Mutant Kras Co-Opts a Progenitor-Associated Transcriptional Network to Drive Pancreatic Tumorigenesis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Jonathan Weitz (University of Miami, USA)
"Homeostatic Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Purinergic Signals from Beta Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Immune Cell-Tissue Cell Interactions
Discussion Leaders: Steven Leach (Dartmouth College, USA) and Marc Donath (University Hospital of Basel, Switzerland)
5:30 pm - 5:45 pm
Introduction by Discussion Leader
5:45 pm - 6:05 pm
Wenxian Fu (University of California, San Diego, USA)
"Role of Macrophages in Islet Niche"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:35 pm
Marina Pasca di Magliano (University of Michigan, USA)
"Oncogenic Kras and the Cellular Cross-Talk in the Pancreatic Cancer Microenvironment"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Hana Algül (Comprehensive Cancer Center Munich, Klinikum Rechts der Isar, Technischen Universität München, Germany)
"Molecular Determinants of PDAC"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Signaling Cascades in Pancreatic Physiology and Pathology
Discussion Leaders: Carmella Evans-Molina (Indiana University School of Medicine, USA) and Ilse Rooman (Vrije Universiteit Brussel, Belgium)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Matthew Vander Heiden (Koch Institute for Integrative Cancer Research at MIT, USA)
"Role of Metabolism in Pancreatic Cancer Progression"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Robert Screaton (University of Toronto, Canada)
"Human Beta Cell Proliferation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Heiko Lickert (Helmholtz Zentrum München, Germany)
"A Novel Scavenger Receptor of the Insulin Signaling Pathway in the Pancreas"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
Selected from Poster Abstracts: Ruiyu Xie (University of Macau, China)
"TET Hydroxylases Facilitate Pancreatic Endocrine Specification Through Modulating the Activity of Lineage-Specific Enhancers"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Aharon Helman (Harvard University, USA)
"A Switch in Nutrient Sensing Controls Glucose Responsiveness of Pancreatic Beta Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Selected from Poster Abstracts: Matteo Ligorio (Massachusetts General Hospital, USA)
"Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Programming and Reprogramming in the Pancreas
Discussion Leaders: Howard Crawford (University of Michigan, USA) and Rohit Kulkarni (Harvard Medical School, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Francesca Spagnoli (King's College London, United Kingdom)
"Pancreatic Cell Reprogramming: Cell Fate Choices and Plasticity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Axel Behrens (The Francis Crick Institute, United Kingdom)
"Understanding Pancreatic Cancer Heterogeneity"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Lewis Murtaugh (University of Utah, USA)
"Reprogramming and Re-Reprogramming Acinar Cells: Ptf1a and Its Allies as Gatekeepers of Plasticity"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure