Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: Genetics of Pancreatic Cancer
Discussion Leader: Ilse Rooman (Vrije Universiteit Brussel, Belgium)
3:15 pm - 3:40 pm
Scott Lowe (Memorial Sloan Kettering Cancer Center, United States)
"Tumor Suppressors and Oncogenes in Pancreatic Cancer"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Luis Arnes (Biotech Research & Innovation Centre, Denmark)
"Non-Coding Regulatory Functions in Pancreatic Ductal Adenocarcinoma"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Epigenome, Microenvironment and Cell Plasticity in Pancreatic Diseases
Discussion Leader: Francisco X. Real (Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Spain)
5:30 pm - 5:40 pm
Direna Alonso Curbelo (Institut de Recerca Biomédica - IRB Barcelona, Spain)
"Neoplastic Co-Option of Tissue Plasticity in Pancreatic Tumorigenesis"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Lorenzo Pasquali (UPF, Spain)
"Noncoding Regularory Functions of Insulin-Secreting Pancreatic Neuroendocrine Tumors"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Heiko Lickert (Helmholtz Zentrum München GmbH, Germany)
"Beta Cell Development and Regeneration"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Marina Pasca di Magliano (University of Michigan, United States)
"Establishment and Regulation of the Pancreatic Cancer Microenvironment"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Melis Akgün (Helmholtz Zentrum München, Germany)
"Dissecting Alpha and Beta Cell Fate Specification During Human Endocrinogenesis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Joan Casamitjana (UB-IDIBELL, Spain)
"Comprehensive Characterization of Pancreatic Ductal Heterogeneity to Identify Multipotent Progenitors"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Danielle Overton (Indiana University Purdue University Indianapolis, United States)
"Understanding How Exocrine-Derived Signals Promote Beta Cell Growth"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Daniel Salas-Escabillas (University of Michigan/Henry Ford Pancreatic Cancer Center, United States)
"The Transforming Taste of Pancreatic Cancer: Uncovering the Fate of Chemosensory Cells in the Progression of Pancreatic Cancer."
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Immune and Metabolic Regulation in Pancreatic Diseases
Discussion Leader: Emilyn Alejandro (U of Minnesota, United States)
9:00 am - 9:10 am
Rachel Perry (Yale University, United States)
"Obesity, Insulin, and Cancer: Pathogenic Mechanisms and Therapeutic Strategies"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Tuomas Tammela (Memorial Sloan Kettering Cancer Center, United States)
"Functional Interrogation of Pancreas Cancer Cell States in Vivo"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Cosimo Commisso (Sanford Burnham Prebys Medical Discovery Institute, United States)
"Regulation of the Tumor Ecosystem by Metabolic Stress"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Shira Yomtoubian (Salk Institute for Biological Studies, United States)
"Deciphering the Role of AMPK in Pancreatic Cancer"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Jinsook Son (Columbia University, United States)
"Genetic and Pharmacologic Inhibition of ALDH1A3 as a Treatment of ß-cell Failure"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Thomas Legøy (University of Bergen, Norway)
"Impact of Diabetogenic Signals From Endocrine Disrupting Chemicals on a HNF1A-MODY Cell Model"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Adrien Grimont (Weill Cornell Medicine, United States)
"Rac1 Enables Senescence Escape and Epithelial Plasticity in Pancreatic Cancer"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Ellis Michiels (Vrije Universiteit Brussel, Belgium)
"High Resolution in Situ Analysis Reveals Phenotypic and Functional Diversification Within Single Pancreatic Tumour Ducts"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development Panel
Discussion Leaders: Diane Simeone (NYU Langone Health - Perlmutter Cancer Center, United States), Rushika Perera (University of California, San Francisco, United States), Carmella Evans-Molina (Indiana University School of Medicine, United States) and Mallika Singh (Revolution Medicines, United States)
1:30 pm - 1:50 pm
Steven Leach (Dartmouth College, United States)
"Regeneration and Renewal: Twenty-Five Years of Mentoring the Next Generation of Investigators in Pancreatic Biology and Disease"
1:50 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
