Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Informing Etiology Through the Clinic
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:15 pm
Introduction by Discussion Leader
8:15 pm - 9:00 pm
"What Is Parkinson's Disease and Why Is It Important for Understanding Biology"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Parkinson's Disease Genetics and Systems Biology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Glucocerebrosidase, Glycosphingolipids and Parkinson's Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Autoimmune Mechanisms in Parkinson's Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Applications of Functional Genomics to Parkinson's Disease"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"High-Content Screening and Genomic Approaches for PD"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Genetics and Biology of Nigral Vulnerability"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Targeting Lysosomal GBA Deficiency for Parkinson's Disease: From Genetics to Therapeutics"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene-Environment Interaction
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Advancing Parkinson's Disease Research by Using Clues from the Environment"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Gene-Environment Interactions in PD: Role of Efflux Transporters"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Assessing Gene-Environment Interactions: Success Stories in Parkinson's Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Synergy Between Common Genetic Variant in Antigen Presentation Capacity and Pyrethroid Exposure Affects Peripheral Immunophenotype and Nigrostriatal Pathway Vulnerability"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
LRRK2: From Protein, Through Cell Biology to Therapeutic Intervention
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"New Assays and Pathways that Activate LRRK2"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"LRRK2 and Macroautophagy: Standing at a Crossroads for Human Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"LRRK2, Mitochondrial DNA Damage and Biomarkers"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"LRRK2 Inhibition in Mediating Alpha-Synuclein Neurotoxicity"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Challenges of Neurodegenerative Disease Drug Discovery: BACE Inhibitors for Alzheimer's Disease vs. LRRK2 Inhibitors for Parkinson's"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Searching for Druggable Targets Using In Silico Simulation of LRRK2 Pathways"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Biology of Aging and Parkinson's Disease
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Generation of Human Neurons by microRNA-Based Neuronal Reprogramming and Modeling of Neurodegeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Targeting Molecular Pathways of Aging as a Treatment Strategy for Parkinson's Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Proteostasis in Biology, Aging, and Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Evidence for Compartmentalized Changes in Neuronal Mitochondrial Biogenesis in a PD-Relevant Model: Assessment of Mitochondrial DNA Replication in Neuron Cell Bodies, Axons, and Dendrites"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Handling and Trafficking
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"PARK14-Dependent Calcium Signaling Is a New Determinant of Autophagic Dysfunction, a-Synuclein Aggregation and PD"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Propagation of Alpha-Synuclein Pathology Along Neural Pathways"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Signaling Pathways for New Axon Growth in Adult Dopamine Neurons"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Molecular Determinants of Alpha-Synuclein Handling in the Cell"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Mechanisms of VPS35-Dependent Neurodegeneration in PD"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"A Link Between Infection, Autoimmune Mechanisms and Parkinson's Disease"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Parkinson's Disease Models: Improving Predictive Value
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Generation of Dopaminergic Systems by Means of Neuronal Transdifferentiation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Prion-Like Dissemination of Human Brain-Derived Alpha-Synuclein in Mice and Monkeys"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"A Progressive, Endogenous Synucleinopathy Model of Parkinson's Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Microglia Influences Prion-Like Propagation of Alpha-Synuclein"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
SNCA: From Protein, Through Cell Biology to Therapeutic Intervention
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"iPS Cell Technology and the Study of Simple and Complex Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Prion-Like Propagation of Alpha-Synuclein Assemblies in Synucleinopathies"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Removal of Alpha-Synuclein from Mature Nigral Neurons In Vivo Results in Toxicity and Neurodegeneration"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
"Alpha-Synuclein Knockdown Is a Promising Therapeutic Strategy for Parkinson's Disease"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"The Aducanumab Story: Lessons Learned from Early-Phase Anti-Amyloid mAb Development for Design of PD Clinical Trials"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Shifting Synuclein Tetramers to Monomers Yields Mice with p-Syn Deposits, TH Loss, Tremor, and Motor Deficits Responsive to L-DOPA"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Inflammation and Immunity in Parkinson's Disease
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:00 pm
"Neuroinflammation in Parkinson's Disease"
6:00 pm - 6:10 pm
Discussion
6:10 pm - 6:30 pm
"Models, Mechanisms, and Therapeutic Interventions"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"The Dynamic Immune Response in PD"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
"Modulation of Inflammation via Cannabinoid Type 2 Receptors to Protect Against Asyn-Induced Degeneration"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure