Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Informing Etiology Through the Clinic
Discussion Leader: Warren Olanow (Icahn School of Medicine at Mount Sinai, USA)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:15 pm
Introduction by Discussion Leader
8:15 pm - 9:00 pm
William Langston (The Parkinson's Institute, USA)
"What Is Parkinson's Disease and Why Is It Important for Understanding Biology"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Parkinson's Disease Genetics and Systems Biology
Discussion Leader: John Hardy (University College London, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Roy Alcalay (Columbia University, USA)
"Glucocerebrosidase, Glycosphingolipids and Parkinson's Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Michel Desjardins (Universite de Montreal, Canada)
"Autoimmune Mechanisms in Parkinson's Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Steven Finkbeiner (University of California, San Francisco, USA)
"Applications of Functional Genomics to Parkinson's Disease"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Peter Heutink (German Center for Neurodegenerative Diseases / University of Tübingen, Germany)
"High-Content Screening and Genomic Approaches for PD"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Matt LaVoie (Brigham and Women's Hospital / Harvard Medical School, USA)
"Genetics and Biology of Nigral Vulnerability"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Pablo Sardi (Genzyme, a Sanofi Company, USA)
"Targeting Lysosomal GBA Deficiency for Parkinson's Disease: From Genetics to Therapeutics"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Roberta Brinton (University of Arizona, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene-Environment Interaction
Discussion Leader: Jeff Bronstein (University of California, Los Angeles, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Gary Miller (Emory University, USA)
"Advancing Parkinson's Disease Research by Using Clues from the Environment"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Jason Richardson (Northeast Ohio Medical University, USA)
"Gene-Environment Interactions in PD: Role of Efflux Transporters"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Beate Ritz (University of California, Los Angeles, USA)
"Assessing Gene-Environment Interactions: Success Stories in Parkinson's Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Selected from Poster Abstracts: Elizabeth Kline (Emory University, USA)
"Synergy Between Common Genetic Variant in Antigen Presentation Capacity and Pyrethroid Exposure Affects Peripheral Immunophenotype and Nigrostriatal Pathway Vulnerability"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
LRRK2: From Protein, Through Cell Biology to Therapeutic Intervention
Discussion Leader: Marco Baptista (The Michael J. Fox Foundation for Parkinson's Research, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Dario Alessi (University of Dundee, United Kingdom)
"New Assays and Pathways that Activate LRRK2"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Patrick Lewis (University of Reading, United Kingdom)
"LRRK2 and Macroautophagy: Standing at a Crossroads for Human Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Laurie Sanders (Duke University, USA)
"LRRK2, Mitochondrial DNA Damage and Biomarkers"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Andrew West (University of Alabama at Birmingham, USA)
"LRRK2 Inhibition in Mediating Alpha-Synuclein Neurotoxicity"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Matthew Kennedy (Merck & Co., USA)
"Challenges of Neurodegenerative Disease Drug Discovery: BACE Inhibitors for Alzheimer's Disease vs. LRRK2 Inhibitors for Parkinson's"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Selected from Poster Abstracts: Bahareh Behrouz (NeuroInitiative, USA)
"Searching for Druggable Targets Using In Silico Simulation of LRRK2 Pathways"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Biology of Aging and Parkinson's Disease
Discussion Leader: Roberta Brinton (University of Arizona, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Andrew Yoo (Washington University School of Medicine, USA)
"Generation of Human Neurons by microRNA-Based Neuronal Reprogramming and Modeling of Neurodegeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Jeremy Van Raamsdonk (Van Andel Research Institute, USA)
"Targeting Molecular Pathways of Aging as a Treatment Strategy for Parkinson's Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Richard Morimoto (Northwestern University, USA)
"Proteostasis in Biology, Aging, and Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Selected from Poster Abstracts: Victor Van Laar (University of Pittsburgh, USA)
"Evidence for Compartmentalized Changes in Neuronal Mitochondrial Biogenesis in a PD-Relevant Model: Assessment of Mitochondrial DNA Replication in Neuron Cell Bodies, Axons, and Dendrites"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Handling and Trafficking
Discussion Leader: David Sulzer (Columbia University Medical Center, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Victoria Bolotina (Boston University School of Medicine, USA)
"PARK14-Dependent Calcium Signaling Is a New Determinant of Autophagic Dysfunction, a-Synuclein Aggregation and PD"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Patrik Brundin (Van Andel Institute, USA)
"Propagation of Alpha-Synuclein Pathology Along Neural Pathways"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Robert Burke (Columbia University, USA)
"Signaling Pathways for New Axon Growth in Adult Dopamine Neurons"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Tiago Outeiro (University Medical Center Goettingen, Germany)
"Molecular Determinants of Alpha-Synuclein Handling in the Cell"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Darren Moore (Van Andel Research Institute, USA)
"Mechanisms of VPS35-Dependent Neurodegeneration in PD"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Selected from Poster Abstracts: Diana Matheoud (Universite de Montreal, Canada)
"A Link Between Infection, Autoimmune Mechanisms and Parkinson's Disease"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Parkinson's Disease Models: Improving Predictive Value
Discussion Leader: Erwan Bezard (University of Bordeaux, France)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Massimiliano Caiazzo (Utrecht University, The Netherlands)
"Generation of Dopaminergic Systems by Means of Neuronal Transdifferentiation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Benjamin DeHay (Institute of Neurodegenerative Diseases, France)
"Prion-Like Dissemination of Human Brain-Derived Alpha-Synuclein in Mice and Monkeys"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Amber Van Laar (University of Pittsburgh, USA)
"A Progressive, Endogenous Synucleinopathy Model of Parkinson's Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Selected from Poster Abstracts: Sonia George (Van Andel Institute, USA)
"Microglia Influences Prion-Like Propagation of Alpha-Synuclein"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
SNCA: From Protein, Through Cell Biology to Therapeutic Intervention
Discussion Leader: Dennis Selkoe (Brigham and Women's Hospital, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Rudolf Jaenisch (Whitehead Institute for Biomedical Research, USA)
"iPS Cell Technology and the Study of Simple and Complex Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Ronald Melki (CNRS, France)
"Prion-Like Propagation of Alpha-Synuclein Assemblies in Synucleinopathies"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
Frederic Manfredsson (Michigan State University, USA)
"Removal of Alpha-Synuclein from Mature Nigral Neurons In Vivo Results in Toxicity and Neurodegeneration"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Edward Burton (University of Pittsburgh School of Medicine, USA)
"Alpha-Synuclein Knockdown Is a Promising Therapeutic Strategy for Parkinson's Disease"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Jesse Cederbaum (Biogen, USA)
"The Aducanumab Story: Lessons Learned from Early-Phase Anti-Amyloid mAb Development for Design of PD Clinical Trials"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Silke Nuber (Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital / Harvard Medical School, USA)
"Shifting Synuclein Tetramers to Monomers Yields Mice with p-Syn Deposits, TH Loss, Tremor, and Motor Deficits Responsive to L-DOPA"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Inflammation and Immunity in Parkinson's Disease
Discussion Leader: Malu Tansey (Emory University, USA)
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:00 pm
Etienne Hirsch (Institut du Cerveau et de la Moelle Epinière / INSERM UMR1127, CNRS, UMR7225, France)
"Neuroinflammation in Parkinson's Disease"
6:00 pm - 6:10 pm
Discussion
6:10 pm - 6:30 pm
Jau-Shyong Hong (National Institute of Environmental Health Sciences, NIH, USA)
"Models, Mechanisms, and Therapeutic Interventions"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Marina Romero-Ramos (NEURODIN, Aarhus University, Denmark)
"The Dynamic Immune Response in PD"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
Selected from Poster Abstracts: Valerie Joers (Emory University, USA)
"Modulation of Inflammation via Cannabinoid Type 2 Receptors to Protect Against Asyn-Induced Degeneration"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure